Role of macrophage migration inhibitory factor on the progression of the aortic aneurysm

• Project/Area Number: 19590846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Asahikawa Medical College
• Principal Investigator: FUKUZAWA Jun Asahikawa Medical College, 医学部, 特任准教授 (40333695)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: マクロファージ / 弾性血管 / ELISA / MMP9 / VEGF

Research Abstract

腹部大動脈瘤形成モデルの確立 : 野生型マウスに対して大動脈瘤作製処置を行い、大動脈径の拡大を観察した。瘤形成部位におけるMIF発現および血中MIF濃度を確認した。MIFの発現細胞をメッセージレベルおよび蛋白レベルで検討した。腹部大動脈瘤作製法 : 3種類の方法を検討した(塩化カルシウム刺激法、アンジオテンシンII注入法、ApoEノックアウトマウス法)。塩化カルシウム刺激法が濃度依存性などの関係で本実験系に適していることがわかった。

Research Products

• [Journal Article] N Scavenger receptor CL-P1 predominantly mediates zymosan phagocytosis by human vascular endothelial cells. (2009)
  • Author(s): Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Mot omura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Su zuki Y, Wakamiva
  • Journal Title: Journal of Biological Chemistry., 284 Pages: 3956-3965
  • Peer Reviewed
• [Journal Article] Immunolocalization of a novel collectin CL-K1 in murine tissues (2008)
  • Author(s): Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J, Mori K, Jang S, Nomura N, Yoshida I, Suzuki Y, Kohgo Y, Wakamiya N
  • Journal Title: Journal of Histochemistry and Cytochemistry 56 Pages: 243-52
  • Peer Reviewed
• [Journal Article] Scavenger receptor CL-P1 predominantly mediates zymosan phagocytosis by human vascular endothelial cells (2008)
  • Author(s): Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N
  • Journal Title: Journal of Biological Chemistry 284 Pages: 3956-3965
  • Peer Reviewed
• [Journal Article] Immunolocalization of a novel collectin CL-K1 in murine tissues (2008)
  • Author(s): Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fuku da M, Fukuzawa J, Mori K, Jang S, Nomura N, Yoshid a I, Suzuki Y, Kohgo Y, Wakamiva N.
  • Journal Title: Journal of Histochemistry and Cytochemistry. 56 Pages: 243-52
  • Peer Reviewed
• [Journal Article] Plenary Session 2 (2008)
  • Author(s): 福澤純、菊池健次郎
  • Journal Title: ISH2008ハイライト 1 Pages: 56-61
• [Journal Article] Immunolocalization of a novel collectin CL-K1 in murine tissues. (2008)
  • Author(s): Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J, Mori K, Jang SJ, Nomura N, Yoshida I, Suzuki Y, Kohgo Y, Wakamiya N.
  • Journal Title: J Histochem Cytochem. 56 Pages: 243-252
  • Peer Reviewed
• [Presentation] Circulating oxidized LDL levels and blood pressure in patients with hemodialysis. (2008)
  • Author(s): Fukuzawa J., Yao N., Haseb e N., Itabe H., Jang S., Ohtani K.. Wakamiva N
  • Organizer: The 22nd Scientific meeting of the International Society of Hypertension
  • Place of Presentation: Berline, Germany
  • Year and Date: 2008-06-19
• [Presentation] Circulating oxidized LDL levels and blood pressure in patients with hemodialysis (2008)
  • Author(s): Fukuzawa J., Yao N., Hasebe N., Itabe H., Jang S., Ohtani K., Wakamiya N.
  • Organizer: The 22nd Scientific meeting of the International Society of Hypertension The 22nd Scientific meeting of the International Society of Hypertension
  • Place of Presentation: Berline, Germany
  • Year and Date: 2008-06-16
• [Presentation] (シンポジウム1「酸化LDL研究の最前線」)血液透析患者における血中酸化LDL値の決定因子、 (2007)
  • Author(s): 福澤純、矢尾尚之、長谷部直幸、菊池健次郎、板部洋之、大谷克城、若宮伸隆
  • Organizer: 第39回日本動脈硬化学会総会(、)
  • Place of Presentation: 大阪
• [Book] 高血圧性臓器障害の評価、「高血圧診療ハンドブックエビデンスに基づく、食事・運動・薬物療法の進め方」. 浦信行編集. (2009)
  • Author(s): 福澤純、長谷部直幸
  • Total Pages: 263
  • Publisher: 羊土社
• [Book] 高血圧性臓器障害の評価、「高血圧診療ハンドブックエビデンスに基づく、食事・運動・薬物療法の進め方」(浦信行編集) (2008)
  • Author(s): 福澤純、長谷部直幸
  • Total Pages: 263
  • Publisher: 羊土社