Novel therapeutic conceot of dementia through vascular axis

• Project/Area Number: 19590861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: NAKAGAMI Hironori Osaka University, 医学系研究科, 助教 (20325369)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脱ユビキチン化酵素 / 血管リモデリング / 認知症 / 動脈硬化 / ユビキチン / パーキンソン病

Research Abstract

パーキンソン病の原因遺伝子であるubiquitin carboxyl-terminal esterase L1(UCHL1)、が血管細胞に発現し脱ユビキチン化作用によって抗炎症作用を所持していた。また血管に存在するその他の脱ユビキチン化酵素であるCYLD(cylindromatosis)に関しても同様に血管で脱ユビキチン化作用を介して血管リモデリングを抑制した。

Research Products

• [Journal Article] Potential role of CYLD(Cylindromatosis)as a deubiquitinating enzyme in vascular cells (2008)
  • Author(s): Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y.
  • Journal Title: Am J Pathol 172(3) Pages: 818-29
  • Peer Reviewed
• [Journal Article] Potential role of CYLD (Cylindromatosis)as a deubiquitinating enzyme in vascular cells. (2008)
  • Author(s): Takami Y, Nakagami H, et al.
  • Journal Title: Am J Pathol. 172 Pages: 818-829
  • Peer Reviewed
• [Journal Article] Ubiquitin carboxyl-terminal hydrolae L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kB activation (2007)
  • Author(s): Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayashi H, Kikkuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y.
  • Journal Title: Arterioscler Thromb Vasc Biol 27(10) Pages: 2184-90
  • Peer Reviewed
• [Journal Article] Ubiquitin carboxyl-terminal hydrolae L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kB activation (2007)
  • Author(s): Takami Y, Nakagami H, et. al.
  • Journal Title: Arterioscler Thromb Vasc Biol. 27(10) Pages: 2184-90
  • Peer Reviewed
• [Presentation] Pivotal role of CYLD(Cylindromatosis)asa Deuhiquitinating enzyme in vasculature (2008)
  • Author(s): 鷹見洋一、中神啓徳, 他
  • Organizer: 日本循環器学会
  • Place of Presentation: マリンメッセ福岡
  • Year and Date: 2008-03-28
• [Presentation] 脱ユビキチン化酵素と動脈硬化 (2007)
  • Author(s): 中神啓徳
  • Organizer: 血管生物医学会
  • Place of Presentation: 日九州大学百年講堂
  • Year and Date: 2007-12-14
• [Presentation] Pivotal role of CYLD (Cylindromatosis) as a Deubiquitinating enzyme in vasculature (2007)
  • Author(s): Yoichi Takami, Hironori Nakagami, et.al.
  • Place of Presentation: Orland, USA
  • Year and Date: 2007-11-05
• [Presentation] Ubiquitin carboxyl-terminal hydrolase Li, a novel deubiquitinating enzyme in vasculature (2007)
  • Author(s): Yoichi Takami, Hironori Nakagami, et.al.
  • Organizer: plays a pivotal roles in vascular remodeling through the inhibition of NF-KB activation
  • Place of Presentation: Orland, USA
  • Year and Date: 2007-11-04