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Establishement of a novel anti-tumor therapy utilizing inhibition of angiogenesis

Research Project

Project/Area Number 19590862
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKobe University

Principal Investigator

ISHIDA Tatsuro  Kobe University, 大学院医学研究科, 助教 (00379413)

Co-Investigator(Kenkyū-buntansha) 平田 健一  神戸大学, 大学院・医学研究科, 教授 (20283880)
小谷 義一  神戸大学, 大学院・医学研究科, 講師 (90403287)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords(1) 血管内皮 / (2) 血管新生 / (3)末梢血管 / (4) 循環器 / (5) 接着分子 / 血管内皮 / 血管新生 / 末梢血管 / 循環器 / 接着分子
Research Abstract

生体内で血管内皮特異的接着分子(ESAM)の機能を阻害することによって腫瘍血管新生が阻害され、結果として腫瘍の成長が抑制されるかどうかを検討した。野生型およびESAM欠損マウスに悪性黒色種細胞を静脈内播種したところ、ESAM欠損マウスでは、有意に肺への腫瘍転移と腫瘍血管の発育が抑制されていた。培養内皮細胞におけるESAM発現は細胞の遊走能と管腔形成能と相関した。以上より、血管に富む腫瘍ではESAMを介する内皮の遊走と管腔形成によって腫瘍血管が増生し、その結果、腫瘍が血管依存的に増大することが示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (16 results) Book (4 results)

  • [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory actions and atherosclerosis in non-diabetic LDL receptor-deficient mice2009

    • Author(s)
      Sun L, Ishida T, Yasuda T, Kuriyama M, Kojima Y, Yamamoto Y, Yamamoto H, Ishibashi S, Hirata K, Hayashi K
    • Journal Title

      Cardiovasc Res 82(2)

      Pages: 371-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy2009

    • Author(s)
      Hara T, Ishida T, Cangara HM, Hirata K
    • Journal Title

      Microvasc Res 77(3)

      Pages: 348-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration2009

    • Author(s)
      Otera H, Ishida T, Nishiuma T, Kobayashi K, Kotani K, Yasuda T, Kundu RK, Quertermous T, Hirata K, Nishimura Y
    • Journal Title

      American Journal of Physiology-Lung Cellular and Molecular Physiology 296(4)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy2009

    • Author(s)
      Hara T, et al.
    • Journal Title

      Microvascular Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice2009

    • Author(s)
      Sun L, et al.
    • Journal Title

      Cardiovascular Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted inactivation of endolhelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration.2009

    • Author(s)
      Otera H, et al.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of endothelial lipase in plasma HDL levels in a murinc model of hypertriglyceridemia2009

    • Author(s)
      Tanaka T, et al.
    • Journal Title

      J Atherosclerosis and Thrombosis (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Adhesion Molecule ESAM1 is A Novel Hematopoietic Stem Cell Marker. Stem Cells2008

    • Author(s)
      Ooi AG, Karsunky H, Majeti R, Butz S, Vestweber D, Ishida T, Quertermous T, Weissman IL, Forsberg EC
    • Pages
      0-0
    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin induces vasoconstriction of smooth muscle cell-rich neointima though 5-hydroxytryptamine2A receptor in rabbit femoral arteries2008

    • Author(s)
      Nishihira K, Yamashita A, Tanaka N, Moriguchi-Goto S, Imamura T, Ishida T, Kawashima S, Yamamoto R, Kitamura K, Asada Y
    • Journal Title

      J Thromb Haemost 6

      Pages: 1207-1214

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages2007

    • Author(s)
      Yasuda T, Hirata K,Ishida T, Kojima Y, Tanaka H, Okada T, Quertermous T, Yokoyama M
    • Journal Title

      J Atheroscler Thromb 14(4)

      Pages: 192-201

    • NAID

      10022606886

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages.2007

    • Author(s)
      Yasuda T, et. al.
    • Journal Title

      J Atheroscler Thromb. 14(4)

      Pages: 192-201

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels.2007

    • Author(s)
      Shimizu M, et. al.
    • Journal Title

      Circ J. 71(6)

      Pages: 842-846

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.2007

    • Author(s)
      Takaya T, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 27(7)

      Pages: 1632-1637

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of endothelial lipase in low HDL levels in a murine model of hypertriglyceridemia

    • Author(s)
      Tanaka H, Ishida T, Johnston TP, Kojima Y, Yasuda T, Kundu RK, Quertermous T, Hirata K
    • Journal Title

      J Atheroscler Thromb

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Inhibition of endothelial lipase increases good cholesterol2009

    • Author(s)
      原 哲也, 他
    • Organizer
      第73回日本循環器学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targetd inactivation of receptor for advanced glycation products reduced oxidative LDL-induced inflammation and atherosclerosis in non-diabetic LDL receptor-/- mice2008

    • Author(s)
      Sun L, Ishida T, Kuriyama M, Yasuda T, Hara T, Hirata K, Hayashi Y
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2008-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Hirata K. Role of endothelial cell-selective adhesion molecule in the progression of atherosclerosis2008

    • Author(s)
      Inoue M, Ishida T, Hara T, Cangara H, Sun L
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of cndolhelial cell-selective adhesion molecule in the progression of atherosclerosis.2008

    • Author(s)
      Inoue M, et al.
    • Organizer
      American Heart Association Scienlific Sessions2008
    • Place of Presentation
      New Orleans LA, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targcled Deletion Of Endothelial Lipase Protects Against Allergic Asthma Through Raising Plasma HDL Level And Attenuating Eosinophil Infiltration.2008

    • Author(s)
      Ishida T, et ai.
    • Organizer
      American Heart Association Scientific Sessions2008
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of pitavastatin on serum concentrations of endothelial lipasc and high-density lipoprotein cholesterol in humans.2008

    • Author(s)
      Sun Li, et al.
    • Organizer
      American Heart Association Scientific Sessions2008
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targetd inactivation of receptor for advanced glycation products reducedoxidative LDL-induced inflammation and atherosclerosis in non-diabetic LDL receptor-/- mice.2008

    • Author(s)
      Sun Li, et al.
    • Organizer
      American Heart Association Scientific Sessions2008
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 家兎における血管内皮リパーゼの過剰発現が血清脂質に及ぼす影響2008

    • Author(s)
      石田達郎, 他
    • Organizer
      第3回ウサギフォーラム
    • Place of Presentation
      神戸
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動脈硬化形成過程におけるendothelial cell-selective adhesion molecule (ESAM)の役割について2008

    • Author(s)
      井上通彦、石田達郎、原哲也、平田健一
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of endothelial lipase in the HDL-raising effects of statins2008

    • Author(s)
      石田達郎, 他
    • Organizer
      第40回日本動脈硬化学会総会学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動脈硬化形成過程におけるendothelial cell-selective adhesionmolecule (ESAM)の役割について2008

    • Author(s)
      井上通彦, 他
    • Organizer
      第40回日本動脈硬化学会総会学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内皮リパーゼの血中濃度と血清HDL値との関係2008

    • Author(s)
      石田達郎, 他
    • Organizer
      第105回日本内科学会訓演会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of endothelial cell-selective adhesion molecule (ESAM) in tumor angiogenesis and metastasis2008

    • Author(s)
      Cangara H, Ishida T, Kuriyama M, Hara T, Inoue M, Yasuda T, Hayashi Y, Hirata K
    • Organizer
      第72回 日本循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] RAGE Deficiency Inhibit the Atherosclerosis Progression in non diabetic Low-Density Lipoprotein Receptor Knockout Mice2008

    • Author(s)
      LiS, Ishida T, Kuriyama M, Yasuda T, Hara T, Hayashi Y, Hirata K
    • Organizer
      第72回 日本循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] High Glucose Stimulation Reduced Endothelial Cell-Selective Adhesion Molecule (ESAM) Expression : A Potential Role in Albuminuria in Diabetic Microangiopathy2008

    • Author(s)
      Hara T, Ishida T, Yasuda T, Okada T, Fukuda A, Inoue M, Kureha F, Hirata K
    • Organizer
      第72回 日本 循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of endothelial cell-selective adhesion molecule(ESAM)in tumor angiogenesis and metastasis2008

    • Author(s)
      Cangara H, et. al.
    • Organizer
      The 72th annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Book] 先端医学社「JELIS」2009

    • Author(s)
      石田達郎、平田健一
    • Publisher
      先端医学社
    • Related Report
      2008 Final Research Report
  • [Book] 新・心臓病診療プラクティスシリーズ12 冠動脈疾患の病態に迫る「高LDLコレステロール血症/低HDLコレステロール血症の関与」2008

    • Author(s)
      石田達郎、平田健一
    • Publisher
      文光堂
    • Related Report
      2008 Final Research Report
  • [Book] β遮断薬のすべて 第3版. 「β遮断薬の血管・血管内皮に対する作用」2008

    • Author(s)
      原哲也、石田達郎、平田健一
    • Publisher
      先端医学社
    • Related Report
      2008 Final Research Report
  • [Book] 循環器疾患最新の治療2008-2009 「冠動脈疾患と抗血小板療法」2008

    • Author(s)
      石田達郎、横山光宏
    • Publisher
      南江堂
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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