NEW THERAPEUTIC STRATEGY FOR CALCIUM CHANNEL BROCKER REGISTANT CORONARY SPASM PATIENTS
| Project/Area Number |
19590868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAYAMA Masafumi Kumamoto University, 医学部, 臨床教授 (30346986)
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| Co-Investigator(Kenkyū-buntansha) |
吉村 道博 東京慈恵会医科大学, 循環器内科, 教授 (30264295)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Mitihiro 東京慈恵会医科大学, 教授 (30264295)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 人間生活環境 / 医療・福祉 / 循環器・高血圧 / 薬理学 / 臨床 / 冠攣縮性狭心症 / スタチン / 臨床研究 / アセチルコリン / カルシウムチャンネル拮抗薬 / 前向き無作為非盲検試験 / 冠攣縮 / 内皮型一酸化窒素合成酵素 / レポーター遺伝子アッセイ |
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| Research Abstract |
臨床研究としてSCAST : Statins Coronary Artery Spasm Trial を施行した。
本研究は、HMG-CoA還元酵素阻害剤(スタチン)が冠攣縮を抑制するか否かを判定することを目的とした臨床研究をおこなった。その結果、通常の療法にフルバスタチンを6ヵ月間追加することにより、AChで冠攣縮が誘発された患者数は、通常の療法に比較して有意に減少した。したがって、スタチン(フルバスタチン)は、新規の冠攣縮治療薬となる可能性があることが明らかとなった。
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Activated endocannabinoid system in coronaryartery disease and antiinflammatory effects ofcannabinoid 1 receptor blockade on macrophages2009
Author(s)
Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y,Izumiya Y, Miyata K, Nakayama M, Kaikita K, ObataT, Takeya M, Ogawa H.
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Journal Title
Circulation 119(1)
Pages: 28-36
Related Report
Peer Reviewed
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[Journal Article] for the SCAST investigators. Effects of3-hydroxy-3-methylglutaryl Coenzyme A ReductaseInhibition on Coronary Spasm after Withdrawal ofCa-channel Blockers2008
Author(s)
Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa N,Nakayama M, Ogawa H, Tayama S, Honda T,Hokimoto S, Ohshima S, Hokamura Y, Kugiyama K,Horie M, Yoshimura M, Harada M, Uemura S, Saito Y
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Journal Title
J Am Coll Cardiol 51
Pages: 1742-8
Related Report
Peer Reviewed
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[Journal Article] Aldosterone, but not angiotensin II,reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes2008
Author(s)
Yamamuro M, Yoshimura M, Nakayama M, Abe K,Sumida H, Sugiyama S, Saito Y, Nakao K, Yasue H,Ogawa H.
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Journal Title
Circ J. 72
Pages: 1346-50
NAID
Related Report
Peer Reviewed
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[Journal Article] A Q312X Mutation in the Hemojuvelin Gene is Associated with Cardiomyopathy due to Juvenile Haemochromatosis2008
Author(s)
Nagayoshi Y, Nakayama M, Suzuki S, Hokamaki J,Shimomura H, Tsujita K, Fukuda M, Yamashita T,Nakamura Y, Sugiyama S, Ogawa H
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Journal Title
European Journal of Heart Failure 10
Pages: 1001-6
Related Report
Peer Reviewed
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[Journal Article] Clinicalfactors affecting serum potassium concentration in cardio-renal decompensation syndrome2008
Author(s)
Ueno H, Yoshimura M, Nakayama M, Yamamuro M, Nishijima T, Kusuhara K, Nagayoshi Y, Kojima S,Kaikita K, Sumida H, Sugiyama S, Ogawa H.
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Journal Title
InternationalJournal of Cardiology
Related Report
Peer Reviewed
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[Journal Article] The Synergistic Combined Effect of Anemia with High Plasma Levels of B-Type Natriuretic Peptide Significantly Predicts an Enhanced Risk for Major Adverse Cardiac Events2008
Author(s)
Ueno H, Nakayama M, Kojima S, Kusuhara K,Nagayoshi Y, Yamamuro M, Nishijima T, Usuku H,Kaikita, K, Sumida H, Yamabe H, Sugiyama S,Yoshimura M, Ogawa H.
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Journal Title
Heart Vessels 23
Pages: 243-248
Related Report
Peer Reviewed
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[Journal Article] The Effects of Long-term Smoking on Endothelial Nitric Oxide Synthase mRNA Expression in Human Platelets as Detected With Real-time Quantitative RT-PCR2007
Author(s)
Shimasaki Y, Saito Y, Yoshimura M, Kamitani S,Miyamoto Y, Masuda I, Nakayama M, Mizuno Y,Ogawa H, Yasue H, Nakao K.
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Journal Title
Clin Appl Thromb Hemost 13
Pages: 43-51
Related Report
Peer Reviewed
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[Journal Article] Predominant Effect of A-Type Natriuretic Peptide on Reduction of Oxidative Stress During the Treatment of Patients with Heart Failure2007
Author(s)
Shono M, Yoshimura M, Nakayama M, YamamuroM, Abe K, Suzuki S, Mizuno Y, Sugiyama S, Saito Y,Nakao K, Yasue H, Ogawa H.
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Journal Title
Circ J. 71
Pages: 1040-1046
NAID
Related Report
Peer Reviewed
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[Journal Article] A Novel Genetic Marker for Coronary Spasm in Women from A Genome-Wide SNP Analysis2007
Author(s)
Suzuki S, Yoshimura M, Nakayama M, Abe K,Yamamuro M, Nagayoshi Y, Kojima S, Kaikita K,Sugiyama S, Yasue H, Ogawa H.
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Journal Title
Pharmacogenet Genomics 17
Pages: 919-30
Related Report
Peer Reviewed
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[Journal Article] The Endothelial Nitric Oxide Synthase Gene -786T/C Polymorphism is a Predictive Factor for Reattacks of Coronary Spasm2007
Author(s)
Nishijima T, Nakayama M, Yoshimura M, Abe K,Yamamuro M, Suzuki S, Shono M, Sugiyama S, Saito Y,Miyamoto Y, Nakao K, Yasue H, and Ogawa H.
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Journal Title
Pharmacogenet Genomics 17
Pages: 581-587
Related Report
Peer Reviewed
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