Role of platelet derived microparticle in the local regulation of vessel function
| Project/Area Number |
19590871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
GOTO Shinya Tokai University, 医学部, 教授 (50225653)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血小板 / microparticle / 炎症性細胞 / 血栓 / 凝固系 / 心筋梗塞 / 脳梗塞 / 血管内皮細胞 / 血管 / 炎症細胞 / 単球 |
|---|
| Research Abstract |
動脈硬化巣周囲の血栓形成にて血小板は必須の役割を演じる。血管内皮細胞機能障害部位に集積した血小板は活性化しmicroparticleを放出する。これは血管内皮、炎症性細胞機能調節、凝固系活性化にも寄与する。産生されたトロンビンは、トロンビン受容体刺激を介してさらに血小板の活性化を促進させることを示した。また、血栓形成に関与する各種細胞機能が、活性化血小板から産生されたmicroparticleにより調節されるメカニズムを示した。また、細胞内小器官であるミトコンドリアの関与を示した。
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy : results of the OPTIMUS-2 study2008
Author(s)
Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM, Guzman LA, Bass TA.
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Journal Title
European Heart Journal 29
Pages: 2202-11
Related Report
Peer Reviewed
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[Journal Article] A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy : results of the OPTIMUS-2 study.2008
Author(s)
Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM, Guzman LA, Bass TA.
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Journal Title
European Heart Journal. 2008 29
Pages: 2202-11
Related Report
Peer Reviewed
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[Journal Article] Risk Factor Profile and Management of Cerebrovascular Patients in the REACH Registry.2008
Author(s)
Roether J, Alberts MJ, Touzec E, Mas JL, Hill MD, Michele P, Bhatt DL, Aichner FT, Goto S, Matsumoto M, Ohman EM, Okada Y, Uchiyama S, D'Agostinom R, Hirsch AT, Wilson PWF, Steg PG, on behalf of the REACH Registry Investigators.
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Journal Title
Cerebrovascular Disease 25
Pages: 366-374
Related Report
Peer Reviewed
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