| Project/Area Number |
19590874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
UEHARA Yoshinari Fukuoka University, 医学部, 講師 (70373149)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
MATSUNAGA Yoichi 徳島文理大学, 薬学部, 教授 (80239053)
YAMADA Tatsuo 福岡大学, 医学部, 教授 (60159217)
|
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 脂質 / 循環器・高血圧 / 高比重リポ蛋白 / 発現制御 / 遺伝子多型 / リポ蛋白 / アポリポ蛋白 / 臨床 / 遺伝子 |
|---|
| Research Abstract |
A novel -257T>G single nucleotide polymorphism (SNP) was found in ATP-Binding Cassette Transporter (ABC) G1 promoter. The -257T>G SNP had a reduced transcriptional activity of ABCG1 invitro. In the clinical analysis of ABCG1 -257T>G SNP, although ABCG1 was not related with plasma cholesterol levels, it was shown that ABCG1 had affected to a lipoprotein composition such as HDL prticle in patients with ischemic heart disease. This is a new finding to show that ABCG1 contributes to protect a progression of atherosclerosis.
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