Interventional approaches to chronic lung diseases by regulation of matrix metalloproteinases

• Project/Area Number: 19590877
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: BETSUYAKU Tomoko Hokkaido University, 大学院・医学研究科, 准教授 (60333605)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: EMMPRIN / basigin / MMP / 上皮細胞 / 再生

Research Abstract

本研究はMatrix metalloproteinases (MMPs) の発現を誘導する膜型糖蛋白basigin/EMMPRIN (extracellular matrix metalloproteinase inducer) という分子に注目し、肺における生理的役割、様々な病態における役割について明らかにした。

Research Products

• [Journal Article] Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia (2009)
  • Author(s): Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC.
  • Journal Title: J Immunol 182 Pages: 3866-3876
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice (2009)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 296 Pages: 614-623
  • Peer Reviewed
• [Journal Article] A soluble factor (EMMPRIN) in exudate influences knee motion after total arthroplasty (2009)
  • Author(s): Onodera J, Onodera S, Kondo E, Betsuyaku T, Yasuda K.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc 17 Pages: 298-304
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease (2009)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Nagai K, Ito Y, Odajima N, Betsuyaku T, Nishimura M.
  • Journal Title: Thorax 64 Pages: 332-338
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M.
  • Journal Title: Respir Med 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Biogerontology 10 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia (2009)
  • Author(s): Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC
  • Journal Title: J Immunol 182 Pages: 3866-3876
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice (2009)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol (in press)
  • Peer Reviewed
• [Journal Article] A soluble factor (EMMPRIN) in exudate influences knee motion after total arthroplasty (2009)
  • Author(s): Onodera J, Onodera S, Kondo E, Betsuyaku T, Yasuda K
  • Journal Title: Knee Surg Sports Traumatol Arthrosc 17 Pages: 298-304
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M
  • Journal Title: Respir Med 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Biogerontology 10 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Diversity of protein carbonylation in allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Journal Title: Free Radic Res 42 Pages: 921-929
  • Peer Reviewed
• [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Journal Title: Am J Respir Cell Mol Biol 37 Pages: 673-682
  • Peer Reviewed
• [Journal Article] Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells (2008)
  • Author(s): Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.
  • Journal Title: Am J Respir Cell MolBiol 39 Pages: 400-411
  • Peer Reviewed
• [Journal Article] Hokkaido COPD Cohort Study Group. : "Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients" (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M.
  • Journal Title: Eur Respir J 32 Pages: 372-378
  • Peer Reviewed
• [Journal Article] Role of basement membrane in EMMPRIN/CD147 induction in rat tracheal epithelial cells (2008)
  • Author(s): Hosokawa T, Betsuyaku T, Odajima N, Suzuki M, Mochitate K, Nasuhara Y, Nishimura M.
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 426-432
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease (2008)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Nagai K, Ito Y, Odajima N, Betsuyaku T. Nishimura M
  • Journal Title: Thorax (in press)
  • Peer Reviewed
• [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Journal Title: Am J Respir Cell Mol Biol 39 Pages: 673-682
  • Peer Reviewed
• [Journal Article] Distal airways in mice exposed to cigarette smoke : Nrf2-regulated genes are increased in Clara cells (2008)
  • Author(s): Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuvaku T
  • Journal Title: Am J Respir Cell Mol Biol 39 Pages: 400-411
  • Peer Reviewed
• [Journal Article] Functional single nucleotide polymorphisms of the CCLS gene and nonemphysematous phenotype in COPD patients (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M ; Hokkaido COPD Cohort Study Group
  • Journal Title: Eur Respir J 32 Pages: 372-378
  • Peer Reviewed
• [Journal Article] Role of basement membrane in EMMPRIN/CD 147 induction in rat tracheal epithelial cells. (2008)
  • Author(s): Hosokawa T, Betsuyaku T, Odajima N, Suzuki M, Mochitate K, Nasuhara Y, Nishimura M
  • Journal Title: Biochem Biophys Res Commun 368(2) Pages: 426-432
  • Peer Reviewed
• [Journal Article] High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological Parameters (2007)
  • Author(s): Hakuma N, Betsuyaku T, Kinoshita I, Itoh T, Kaga K, Kondo S, Nishimura M, Dosaka-Akita H.
  • Journal Title: Oncology 72 Pages: 197-204
  • Peer Reviewed
• [Journal Article] Loss of caveolin-1 in bronchiolization in lung fibrosis (2007)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M.
  • Journal Title: J Histochem Cytochem 55 Pages: 899-909
  • Peer Reviewed
• [Journal Article] Differentiation of tracheal basal cells to ciliated cells and tissue reconstruction on the synthesized basement membrane substratum in vitro (2007)
  • Author(s): Hosokawa T, Betsuyaku T, Nishimura M, Furuyama A, Katagiri K, Mochitate K.
  • Journal Title: Connect Tissue Res 48 Pages: 9-18
  • NAID: 10021231416
  • Peer Reviewed
• [Journal Article] Molecular and functional properties of lung SP cells (2007)
  • Author(s): Reynolds SD, Shen H, Reynolds PR, Betsuyaku T, Pilewski JM, Gambelli F, Di Giuseppe M, Ortiz LA, Stripp BR.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 292
  • Peer Reviewed
• [Journal Article] High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological Parameters. (2007)
  • Author(s): Hakuma N, Betsuyaku T, Kinoshita I, Itoh T, Kaga K, Kondo S, Nishimura M, Dosaka-Akita H
  • Journal Title: Oncology 72(3-4) Pages: 197-204
  • Peer Reviewed
• [Journal Article] Loss of caveolin-1 in bronchiolization in lung fibrosis (2007)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
  • Journal Title: J Histochem Cytochem 55(9) Pages: 899-909
  • Peer Reviewed
• [Journal Article] Differentiation of tracheal basal cells to ciliated cells and tissue reconstruction on the synthesized basement membrane substratum in vitro (2007)
  • Author(s): Hosokawa T, Betsuyaku T, Nishimura M, Furuyama A, Katagiri K, Mochitate K
  • Journal Title: Connect Tissue Res 48(1) Pages: 9-18
  • NAID: 10021231416
  • Peer Reviewed
• [Journal Article] Molecular and functional properties of lung SP cells. (2007)
  • Author(s): Reynolds SD, Shen H, Reynolds PR, Betsuyaku T, Pilewski JM, Gambelli F, Di Giuseppe M, Ortiz LA, Stripp BR
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 292(4)
  • Peer Reviewed
• [Presentation] EMS10-2 Laminins α5 and γ2 and VEGF are Down-regulated in Lung in Cigarette Smoke-exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk TL, Nguyet M. Nguyen, Senior RM, Nishimura M.
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] アレルギー性気道炎症モデル及び喘息患者における気道被覆液中のカルボニル化蛋白の検討 (2008)
  • Author(s): 長井桂, 別役智子,今野 哲, 伊藤洋子, 南須原康行, 檜澤伸之, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 線維化肺におけるcatalase発現の検討 (2008)
  • Author(s): 小田島奈央, 別役智子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] COPDの気流制限に及ぼす3次元CT画像で評価した気腫病変と気道病変の関与 (2008)
  • Author(s): 長谷川 大, 南須原康行, 牧田比呂仁, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 単回喫煙暴露マウスモデルでの好中球性炎症および細気管支上皮のケモカイン産生におよぼす加齢の影響 (2008)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 臨床安定期の中・高年気管支喘息患者における気流制限と肺CT3次元気道解析でみた気道病変との関係 (2008)
  • Author(s): 清水薫子, 南須原康行, 長谷川大, 牧田比呂仁, 今野哲, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] EMS10-2 Laminins a5 and r2 and VEGF are Down-regulated in Lung in Cigarette Smoke-exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara N, Kaga K, Kondo S, Hamamura I, Adair-Kirk TL, Nguyet M. Nguyen, Senior RM, Nishimura M
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] アレルギー性気道炎症モデル及び喘息患者における気道被覆液中のカルポニル化蛋白の検討 (2008)
  • Author(s): 長井桂, 別役智子, 今野哲, 伊藤洋子, 南須原康行, 檜澤伸之, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] PP772線維化肺におけるcatalase発現の検討 (2008)
  • Author(s): 小田島奈央, 別役智子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] MS255・PP695単回喫煙暴露マウスモデルでの好中球性炎症および細気管支上皮のケモカイン産生におよぼす加齢の影響 (2008)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke (CS) Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aging Affects Lipopolysaccaride (LPS) - Induced Upregulation of Heme Oxygenase-1 (HO-1) in the Lungs and Alveolar Macrophages (AMs) (2008)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) Assessed by Three-dimensional Computed Tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke (CS)-Exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T, Nguyen NM, Senior RM, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke (CS) Exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, J. Hata J, Takahashi H, Nasuhara Y, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area,airway luminal area measured by three-dimensional computedtomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid (BALF) from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Hayashi M, Yamagata A, Oofusa K, Takada T, Betsuyaku T, Nishimura M, Nakata K.
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO
  • Year and Date: 2008-05-20
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke (CS) Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aging Affects Lipopolysaccaride (LPS)-Induced Upregulation of Herne Oxygenase-1 (H0-1) in the Lungs and Alveolar Macrophages (AMs) (2008)
  • Author(s): Ito. Y, Betsuyaku T,Moriyama C, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) Assessed by Three-dimensional Computed Tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke (CS)-Exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara M, Kaga K, Kondo S, Hamamura I, Adair-Kirk T, Nguyen NM, Senior RM, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke (CS) Exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, J. Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Proteomic Analysis of Bronchoalveolar Lavage Fluid (BALF) from Subjects with Pulmonary Emphysema (2008)
  • Author(s): Hayashi M, Yamagata A, Oofusa K, Takada T, Betsuyaku T, Nishimura M. Nakata K
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease (COPD) (2007)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Onodera Y, Betsuyaku T, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-21
• [Presentation] Aged mice exhibit enhanced neutrophilic inflammation after short-term cigarette smoke (CS) exposure (2007)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Nasuhara Y, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-21
• [Presentation] Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is Highly Expressed in Lymphangioleiomyomatosis (LAM) (2007)
  • Author(s): Odajima N, Bestuyaku T, Suzuki M, Hosokawa T, Nasuhara Y, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-21
• [Presentation] Catalase mRNA expression in bronchiolar epithelium in mice is up-regulated by acute cigarette smoke (CS) exposure and down-regulated by chronic CS exposure (2007)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Mitsuhashi H, Adair-Kirk TL, Griffin GL, Senior RM, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-21
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Onodera Y, Betsuyaku T, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-21
• [Presentation] Aged mice exhibit enhanced neutrophilic inflammation after short-term cigarette smoke(CS)exposure (2007)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-21
• [Presentation] Extracellular Matrix Metalloproteinase Inducer(EMMPRIN)is Highly Expressed in Lymphangioleiomyomatosis(LAM) (2007)
  • Author(s): Odajima N, Bestuyaku T, Suzuki M, Hosokawa T, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: California USA
  • Year and Date: 2007-05-21
• [Presentation] Impaired Cigarette Smoke Extract (CSE)-induced Upregulation of Heme Oxigenase-1 (HO-1) in Alveolar Macrophages (AMs) but not in Peritoneal Macrophages (PMs) in Aged Mice (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-20
• [Presentation] Diverse Expression of Phosphatidylserine Receptor (PSR) and Vitronectin Receptor (VnR) in Monocytic Cell Lineage and Alveolar Macrophages (AMs) in Smokers (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-20
• [Presentation] Dual function NADPH oxidase/heme peroxidase (Duox) 1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease (COPD) (2007)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Ito Y, Nasuhara Y, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-20
• [Presentation] Increase of Sputum Protein Carbonyls as an Oxidative Stress Marker in Asthma (2007)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-20
• [Presentation] NF-E2-related factor 2 (Nrf2) expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients (2007)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA : Moscone Center
  • Year and Date: 2007-05-20
• [Presentation] Catalase mRNA expression in bronchiolar epithelium in mice is up-regulated by acute cigarette smoke(CS)exposure and down-regulated by chronic CS exposure (2007)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Mitsuhashi H, Adair-Kirk TL, Griffin GL, Senior RM, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: California USA
  • Year and Date: 2007-05-20
• [Presentation] Impaired Cigarette Smoke Extract(CSE)-induced Upregulation of Heme Oxigenase-1(HO-1)in Alveolar Macrophages(AMs)but not in Peritoneal Macrophages(PMs)in Aged Mice (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-20
• [Presentation] Diverse Expression of Phosphatidylserine Receptor(PSR)and Vitronectin Receptor(VnR)in Monocytic Cell Lineage and Alveolar Macrophages(AMs)in Smokers (2007)
  • Author(s): Ito Y, Betsuyaku T, Nagai K, Suzuki M, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-20
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-20
• [Presentation] Increase of Sputum Protein Carbonyls as an Oxidative Stress Marker in Asthma (2007)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: San Francisco USA
  • Year and Date: 2007-05-20
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2007)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Organizer: The 103th American Thoracic Society International Conference
  • Place of Presentation: California USA
  • Year and Date: 2007-05-20
• [Presentation] シンポジウム7 呼吸器疾患と慢性炎症「慢性喫煙暴露とCOPDの病態における炎症性サイトカインの役割」 (2007)
  • Author(s): 別役智子
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-12
• [Presentation] COPDにおける抗酸化遺伝子発現とその調節機構 (2007)
  • Author(s): 別役智子
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] 慢性喫煙暴露とCOPDの病態における炎症性サイトカインの役割 (2007)
  • Author(s): 別役智子
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] Impaired Cigarette Smoke Extract-induced Upregulation of Heme Oxigenase-1 (HO-1) in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Impaired Cigarette Smoke Extract-induced Upregulation of Heme Oxigenase-1 (HO-1) in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Impaired Cigarette Smoke Extract-induced Upregulation of Heme Oxigenase-1 (HO-1) in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Mice (2007)
  • Author(s): 伊藤洋子, 別役智子, 長井桂, 鈴木雅, 南須原康行, 西村正治
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] NF-E2-related factor 2 (Nrf2) expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients (2007)
  • Author(s): 鈴木雅, 別役智子, 伊藤洋子, 長井 桂, 南須原康行, 加賀基地三, 近藤 哲, 西村正治
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] Dual function NADPH oxidase/heme peroxidase (Duox) 1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary Disease (COPD) (2007)
  • Author(s): 長井桂, 別役智子, 鈴木 雅, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease (COPD) (2007)
  • Author(s): 長谷川 大, 南須原康行, 牧田比呂仁, 小野寺祐也, 別役智子, 西村正治
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] 短期喫煙暴露モデルにおける好中球性炎症に対する加齢の影響 (2007)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京 : 東京国際フォーラム
  • Year and Date: 2007-05-11
• [Presentation] シンポジウム1 気管支喘息・COPDの分子病態の解明と治療への挑戦「COPDにおける抗酸化遺伝子発現とその調節機構」 (2007)
  • Author(s): 別役智子
  • Organizer: 第47回呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] Impaired Cigarette Smoke Extract-induced Upregulation of Home Oxigenase-1(HO-1)in Alveolar Macrophages but not in Peritoneal Macrophages in Aged Mice (2007)
  • Author(s): 伊藤洋子, 別役智子, 長井 桂, 鈴木 雅, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] NF-E2-related factor 2(Nrf2)expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2007)
  • Author(s): 鈴木 雅, 別役智子, 伊藤洋子, 長井 桂, 南須原康行, 加賀基地三, 近藤 哲, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] Dual function NADPH oxidase/heme peroxidase(Duox)1 and 2 Expression in Airway Epithelium in Smokers and Chronic Obstructive Pulmonary (2007)
  • Author(s): 長井 桂, 別役智子, 鈴木 雅, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] Relationship of Emphysema with Airway Dimensions in Chronic Obstructive Pulmonary Disease(COPD) (2007)
  • Author(s): 長谷川 大, 南須原康行, 牧田比呂仁, 小野寺祐也, 別役智子, 西村正治
  • Organizer: 第47回日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] 短期喫煙暴露モデルにおける好中球性炎症に対する加齢の影響 (2007)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第47回日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-11
• [Presentation] Lymphangioleiomyomatosis (LAM) におけるExtracellular Matrix Metalloproteinase(EMMPRIN)発現の検討 (2007)
  • Author(s): 小田島奈央, 別役智子, 鈴木雅, 細川剛, 南須原康行, 西村正治
  • Organizer: 第104回日本内科学会
  • Place of Presentation: 大阪 : 大阪国際会議場
  • Year and Date: 2007-04-04
• [Presentation] Lymphangioleiomyomatosis(LAM)におけるExtracellular Matrix Metalloproteinase(EMMPRIN)発現の検討 (2007)
  • Author(s): 小田島奈央, 別役智子, 鈴木 雅, 細川 剛, 南須原康行, 西村正治
  • Organizer: 第104回日本内科学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-04