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Dissecting the pathoIogical mechanism of the pulmonary arterial hypertension

Research Project

Project/Area Number 19590884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

TADA Yuji  Chiba University, 医学部・附属病院, 助教 (50344990)

Co-Investigator(Kenkyū-buntansha) KURIYAMA Takayuki  千葉大学, 大学院・医学研究院, 教授 (20009723)
TATSUMI Koichiro  千葉大学, 大学院・医学研究院, 准教授 (10207061)
TAKIGUCHI Yuichi  千葉大学, 医学部・附属病院, 講師 (30272321)
ANABE Nobuhiro  千葉大学, 医学部・附属病院, 講師 (40292700)
Co-Investigator(Renkei-kenkyūsha) TATSUMI Koichiro  千葉大学, 大学院・医学研究院, 教授 (10207061)
TAKIGUCHI Yuichi  千葉大学, 医学部・附属病院, 准教授 (30272321)
TANABE Nobuhiro  千葉大学, 医学部・附属病院, 講師 (40292700)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords肺高血圧 / BMPR2 / トランスジェニックマウス / エストロゲン / 原発性肺高血圧症 / 遺伝子異常 / エストロケン受容体
Research Abstract

原発性肺高血圧の原因遺伝子であるBMPR2の発現を抑制できるトランスジェニックマウスを用い、外因性エストロゲンの病態への影響を調べた。米国の共同研究者からマウスの譲渡を受け、コロニーの繁殖と肺高血圧の表現系を再確認した。結果的にエストロゲン持続投与は肺高血圧の進展に有意な影響を及ぼさなかった。また治療実験としてRhoK阻害剤、PDGFB阻害剤の投与により当該マウスの肺高血圧が改善した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Murine pulmonary response to chronic hypoxia is strain specific2008

    • Author(s)
      Tada Y, Laudi S, Harral J, Carr M, Ivester C, Tanabe N, Takiguchi Y, Tatsumi K, Kuriyama T, Nichols WC, West J.
    • Journal Title

      Experimental Lung research 34(6)

      Pages: 313-23

    • Related Report
      2008 Final Research Report
  • [Journal Article] Murine pulmonary response to chronic hypoxia is strain specific.2008

    • Author(s)
      多田裕司
    • Journal Title

      Experimental Lung Research 34(6)

      Pages: 313-323

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH2007

    • Author(s)
      多田, 裕司
    • Journal Title

      Am J Physiology Lung Cell Mol Physiology 292(6)

      Pages: 1556-1563

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daytime hypercapnia in obstructive sleep apnea syndrome2007

    • Author(s)
      川田, 奈緒子
    • Journal Title

      Chest 132(6)

      Pages: 1832-1838

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells2007

    • Author(s)
      坂尾, 誠一郎
    • Journal Title

      The FASEB journal 21(13)

      Pages: 3640-3652

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse of pulmonary arterial hypertension2007

    • Author(s)
      多田, 裕司
    • Organizer
      American Thoracic Society 2007 International Conference
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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