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Is idiopathic interstitial pneumonia really etiology-unknown disease? A quantitative element analysis will be performed

Research Project

Project/Area Number 19590885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNiigata University

Principal Investigator

TAKADA Toshinori  Niigata University, 医歯学系, 講師 (40361919)

Co-Investigator(Kenkyū-buntansha) SUZUKI Eiichi  新潟大学, 医歯学総合病院, 教授 (30187710)
TERADA Masaki  新潟大学, 医歯学総合病院, 助教 (50401740)
渡辺 孝一  新潟大学, 医歯学系, 准教授 (20018766)
Co-Investigator(Renkei-kenkyūsha) WATANABE Koichi  新潟大学, 医歯学系, 准教授 (20018766)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords間質性肺炎 / 電子線マイクロアナライザー / 超硬合金肺 / 元素分析
Research Abstract

X線マイクロアナライザーと画像解析ソフトウェアを用いて、間質性肺炎肺組織中に存在する元素量を半定量化した.特発性肺線維症8例と膠原病に伴う間質性肺炎10例を対象として、窒素、ケイ素、アルミニウム、鉄、マグネシウム、チタンの各元素の数値を統計学的に比較したところ、特発性肺線維症においてケイ素とアルミニウムが有意に多く含まれていた.また組織量を示す窒素で除した値の比較でも、同様の差がみられた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Surface analysis of commercially pure titanium implant retrieved from rat bone2009

    • Author(s)
      Watanabe K, Okawa S, Kanatani M, et.al.
    • Journal Title

      Part 1 : Initial biological response of sandblasted surface Dent Mater J 28

      Pages: 178-184

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences of lymphocyte profile between BAL fluid and human lung tissue from patients with interstitial lung disease2008

    • Author(s)
      Fujimori F, Takada T, Suzuki E, et.al.
    • Journal Title

      Brit J Biomed Sci 65

      Pages: 63-67

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences of lymphocyte profile between BAL fluid and human lung tissue from patients with interstitial lung disease.2008

    • Author(s)
      Fujimori F, Takada T, Suzuki E, 他
    • Journal Title

      Brit J Biomed Sci 65

      Pages: 63-67

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice.2008

    • Author(s)
      Tajima S, Takada T, Suzuki E, 他
    • Journal Title

      Respirology 13

      Pages: 646-653

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of edaravone, a free radical scavenger, on bleomycin-induced lung injury in mice.2008

    • Author(s)
      Tajima S, Takada T, Suzuki E, 他
    • Journal Title

      Eur Respir J 32

      Pages: 1337-1343

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-dimensional analysis of elements and mononuclear cells in hard metal lung disease2007

    • Author(s)
      Moriyama H, Takada T, Terada M, Watanabe K, Suzuki E, et.al.
    • Journal Title

      Am J Respir Crit Care Med 176

      Pages: 70-77

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-dimensional analysis of elements and mononuclear cells in hardmetal lung disease.2007

    • Author(s)
      森山寛史, 他
    • Journal Title

      Am J Respir Crit Care Med 176

      Pages: 70-77

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 波長分散型X線マクロアナライザーを用いた職業性肺疾患の微量元素分析2008

    • Author(s)
      森山寛史、高田俊範、寺田正樹、鈴木榮一、他
    • Organizer
      間質性肺炎分子病態研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-02
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 波長分散型X線マイクロアナライザーを用いた超硬合金肺の肺内元素数値化の試み2007

    • Author(s)
      島岡雄一、高田俊範、寺田正樹、鈴木栄一、他
    • Organizer
      間質性肺炎分子病態研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-25
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Quantitative analysis of lung elements of hard metal lung disease detected by two-dimensional electron probe microanalyzer2007

    • Author(s)
      Shimaoka Y, Takada T, Terada M, Watanabe K, Suzuki E, et.al.
    • Organizer
      2007年米国胸部疾患学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Quantitative analysis of lung elements of hard metal lung disease detected bytwo-dimensional electron probe microanalyzer2007

    • Author(s)
      島岡雄一, 他
    • Organizer
      2007年米国胸部疾患学会
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸器症候群(第二版)、I I びまん性肺疾患2008

    • Author(s)
      森山寛史、高田俊範、寺田正樹、鈴木榮一
    • Publisher
      日本臨床社
    • Related Report
      2008 Final Research Report
  • [Book] 呼吸器症候群(第二版)、II びまん性肺疾患、D. じん肺および室内・大気環境汚染による肺疾患、超硬合金肺2008

    • Author(s)
      森山寛史, 高田俊範, 寺田正樹, 鈴木榮一
    • Publisher
      日本臨床社
    • Related Report
      2008 Annual Research Report
  • [Book] 微細加工と表面処理-ナノ・マイクロ構造による光学, 摩擦, ぬれ等の機能実現-2007

    • Author(s)
      渡辺孝一
    • Publisher
      リアライズ理工センター
    • Related Report
      2008 Final Research Report
  • [Book] 微細加工と表面処理-ナノ・マイクロ構造による光学, 摩擦, ぬれ等の機能実現-2007

    • Author(s)
      渡辺孝一(分担執筆)
    • Publisher
      リアライズ理工センター,東京
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体組織中の微量元素分析装置2007

    • Inventor(s)
      小林正義, 渡邊孝一
    • Industrial Property Rights Holder
      株式会社新潟ティーエルオー
    • Acquisition Date
      2007-05-25
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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