| Project/Area Number |
19590901
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
SODA Hiroshi Nagasaki University, 大学院・医歯薬学総合研究科, 客員研究員 (60244042)
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| Co-Investigator(Kenkyū-buntansha) |
中村 洋一 長崎大学, 医学部・歯学部附属病院, 助教 (20432974)
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| Research Collaborator |
NAKAMURA Yoichi 長崎大学, 病院, 助教 (20432974)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肺癌 / 分子標的治療 / 個別化治療 / 上皮成長因子受容体阻害 / 肺サーファクタント蛋白 / 上皮成長因子受容体阻害薬 |
|---|
| Research Abstract |
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have dramatic effects in selective patients with non-small cell lung cancer. A non-invasive method for predicting the efficacy of EGFR tyrosine kinase inhbitors is needed in clinical settings. The production of surfactant proteins is reported to be regulated through the EGF signaling pathway. The present study suggested that EGFR mutations in the tumor and high levels of serum surfactant protein-D before treatment may predict the efficacy of EGFR tyrosine kinase inhibitors.
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