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Surfactant protein regulates the activity of matrix metalloproteineses

Research Project

Project/Area Number 19590904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionSapporo Medical University

Principal Investigator

MITSUZAWA Hiroaki  Sapporo Medical University, 医学部, 講師 (40325874)

Co-Investigator(Kenkyū-buntansha) KUROKI Yoshio  札幌医科大学, 医学部, 教授 (70161784)
SHIMIZU Takeyuki  札幌医科大学, 医学部, 講師 (10339137)
NISHITANI Chiaki  札幌医科大学, 医学部, 助教 (30381255)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsコレクチン / 肺サーファクタント蛋白質 / マトリックスメタロプロテアーゼ / 肺気腫 / 間質性肺炎 / 自然免疫 / メタロプロテアーゼ
Research Abstract

肺サーファクタンント蛋白質D(SP-D)が、細胞外基質分解酵素であるマトリックスメタロプロテアーゼ(MMP)の活性を抑制することが本研究によって示された。SP-Dは、従来より知られてきた自然免疫作用のみならず、肺組織内でのMMP活性を制御することによって、肺の組織恒常性維持に関与しており、MMP活性亢進が病態に関わるような肺気腫や間質性肺炎などの呼吸器疾患の発症を抑止している可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain2008

    • Author(s)
      Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y
    • Journal Title

      Biochemistry 47

      Pages: 12878-85

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells2008

    • Author(s)
      Chmura K, Bai X, Nakamura M, Kandasamy P, McGibney M, Kuronuma K, Mitsuzawa H, Voelker DR, Chan ED
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 295

      Pages: 220-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors.2008

    • Author(s)
      Yamazoe M.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 35878-35888

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.2008

    • Author(s)
      Nie X.
    • Journal Title

      Biochemistry 47

      Pages: 12878-12885

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of IL-8 by Mycoplasma pneumoniae in BEAS-2B cells.2008

    • Author(s)
      Chmura K
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 295

      Pages: 220-230

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The microtubule binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A J Biol Chem2007

    • Author(s)
      Sano H, Ishino M, Kramer H, Shimizu T, Mitsuzawa H, Nishitani C, Kuroki Y
    • Journal Title

      282

      Pages: 7973-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 6-Fluoro-8-methoxy-quinolone, gatifloxacin, downregulates IL-8 production in prostate cell line PC-32007

    • Author(s)
      Takeyama K, Mitsuzawa H, Nishitani C, Shimizu T, Sano H, Kunishima Y, Takahashi S, Hotta H, Matsukawa M, Shibata K, Tsukamoto T, Kuroki Y
    • Journal Title

      Antimicrob Agents Chemother 51(1)

      Pages: 162-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] SP-Dによるマトリックスメタロプロテアーゼ活性制御2009

    • Author(s)
      光澤博昭
    • Organizer
      医化学フォーラム札幌2009
    • Place of Presentation
      札幌
    • Year and Date
      2009-03-20
    • Related Report
      2008 Final Research Report
  • [Book] Immunomodulatory functions of pulmonary collectins.2007

    • Author(s)
      Hiroaki Mitsuzawa
    • Total Pages
      22
    • Publisher
      Research Signpost
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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