Surfactant protein regulates the activity of matrix metalloproteineses

• Project/Area Number: 19590904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: MITSUZAWA Hiroaki Sapporo Medical University, 医学部, 講師 (40325874)
• Co-Investigator(Kenkyū-buntansha): KUROKI Yoshio 札幌医科大学, 医学部, 教授 (70161784) ; SHIMIZU Takeyuki 札幌医科大学, 医学部, 講師 (10339137) ; NISHITANI Chiaki 札幌医科大学, 医学部, 助教 (30381255)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: コレクチン / 肺サーファクタント蛋白質 / マトリックスメタロプロテアーゼ / 肺気腫 / 間質性肺炎 / 自然免疫 / メタロプロテアーゼ

Research Abstract

肺サーファクタンント蛋白質D(SP-D)が、細胞外基質分解酵素であるマトリックスメタロプロテアーゼ(MMP)の活性を抑制することが本研究によって示された。SP-Dは、従来より知られてきた自然免疫作用のみならず、肺組織内でのMMP活性を制御することによって、肺の組織恒常性維持に関与しており、MMP活性亢進が病態に関わるような肺気腫や間質性肺炎などの呼吸器疾患の発症を抑止している可能性が示された。

Research Products

• [Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain (2008)
  • Author(s): Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y
  • Journal Title: Biochemistry 47 Pages: 12878-85
  • Peer Reviewed
• [Journal Article] Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells (2008)
  • Author(s): Chmura K, Bai X, Nakamura M, Kandasamy P, McGibney M, Kuronuma K, Mitsuzawa H, Voelker DR, Chan ED
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 295 Pages: 220-30
  • Peer Reviewed
• [Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors. (2008)
  • Author(s): Yamazoe M.
  • Journal Title: J. Biol. Chem. 283 Pages: 35878-35888
  • Peer Reviewed
• [Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain. (2008)
  • Author(s): Nie X.
  • Journal Title: Biochemistry 47 Pages: 12878-12885
  • Peer Reviewed
• [Journal Article] Induction of IL-8 by Mycoplasma pneumoniae in BEAS-2B cells. (2008)
  • Author(s): Chmura K
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 295 Pages: 220-230
  • Peer Reviewed
• [Journal Article] The microtubule binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A J Biol Chem (2007)
  • Author(s): Sano H, Ishino M, Kramer H, Shimizu T, Mitsuzawa H, Nishitani C, Kuroki Y
  • Journal Title: 282 Pages: 7973-81
  • Peer Reviewed
• [Journal Article] 6-Fluoro-8-methoxy-quinolone, gatifloxacin, downregulates IL-8 production in prostate cell line PC-3 (2007)
  • Author(s): Takeyama K, Mitsuzawa H, Nishitani C, Shimizu T, Sano H, Kunishima Y, Takahashi S, Hotta H, Matsukawa M, Shibata K, Tsukamoto T, Kuroki Y
  • Journal Title: Antimicrob Agents Chemother 51(1) Pages: 162-8
  • Peer Reviewed
• [Presentation] SP-Dによるマトリックスメタロプロテアーゼ活性制御 (2009)
  • Author(s): 光澤博昭
  • Organizer: 医化学フォーラム札幌2009
  • Place of Presentation: 札幌
  • Year and Date: 2009-03-20
• [Book] Immunomodulatory functions of pulmonary collectins. (2007)
  • Author(s): Hiroaki Mitsuzawa
  • Total Pages: 22
  • Publisher: Research Signpost