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Exposure to air pollution during pregnancy increases asthma susceptibility in the next generation

Research Project

Project/Area Number 19590907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNara Medical University

Principal Investigator

HAMADA Kaoru  Nara Medical University, 医学部, 教授 (80228535)

Co-Investigator(Kenkyū-buntansha) 木村 弘  奈良県立医科大学, 医学部, 教授 (20195374)
須崎 康恵  奈良県立医科大学, 医学部, 助教 (30382302)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords気管支喘息 / 大気汚染
Research Abstract

気管支喘息などアレルギー疾患は世界的に増加している. 大気汚染はその重要な発症要因の一つである. 妊娠中の大気汚染曝露が小児アレルギー疾患発症の抗原非特異的危険因子となるか否かについてマウスモデルで検討した. 大気汚染として石油燃焼灰燼の影響はすでに報告したが(文献3)、室内気汚染(ホルムアルデヒド、タバコ煙)についても、妊娠中の曝露で仔マウスは喘息病態を発症しやすくなることが示された. 曝露により新生児期の免疫状態に影響することが認められ、次世代のアレルギー疾患発症に対する環境因子と一次予防の重要性が強調された結果となった. また、発展的な研究としてケモカイン受容体阻害薬の喘息発症抑制効果を明らかとし、喘息発症におけるTh1リンパ球の関与を示した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] A small-molecule compound targeting CCR5/CXCR3 prevents airway hyperresponsiveness and inflammation2009

    • Author(s)
      Suzaki Y, Hamada K, Kimura H et.al.
    • Journal Title

      Eur Respir J 31(4)

      Pages: 783-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation.2008

    • Author(s)
      Suzaki Y, Hamada K, et al
    • Journal Title

      European Respiratory Journal. 31

      Pages: 783-789

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule compound targeting CCR5 and CXCR3 prevents the development of asthma.2008

    • Author(s)
      Suzaki Y, Hamada K, Nomi T, et. al.
    • Journal Title

      Eur Respir J 31

      Pages: 783-789

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-8 response of cyclically stretching alveolar epithelial cells exposed to non-fibrous particles2007

    • Author(s)
      Mijailovich SM, Hamada K, Tsuda A
    • Journal Title

      Ann Biomed Eng 35

      Pages: 582-594

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring2007

    • Author(s)
      Hamada K, Suzaki Y, Kimura H, et.al.
    • Journal Title

      J Toxicol Environ Health A 70(8)

      Pages: 688-95

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring2007

    • Author(s)
      Hamade K, Suzaki Y, Leme A, et. al.
    • Journal Title

      J Toxicol Environ Health 70

      Pages: 688-695

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cigarette smoking accelerates airway remodeling of childhood astima in a murine model.2007

    • Author(s)
      Hamada K, Suzaki Y, Ito T, et. al.
    • Organizer
      American Thoracic Society(ATS)2007 International Conference
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cigarette smoking accelerates airway remodeling of childhood asthma in a murine model2007

    • Author(s)
      Hamada K, Suzaki Y, Kimura H
    • Organizer
      American Thoracic Society 2007 Interntnl Conf
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] A synthetic Non-Peptide Compound Targeting CCR5 Prevents the Development of Asthma in a Murine Model2007

    • Author(s)
      Suzaki Y, Hamada K, Kimura H, et.al.
    • Organizer
      2007 AMERICAN ACADEMY OF ALLERGY ASTHMA &IMMUNOLOGY
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 胎児期および乳幼児期の室内空気汚染物質ホルムアルデヒド曝露が喘息発症に及ぼす影響についての検討2007

    • Author(s)
      須崎康恵, 濱田薫, 木村弘ら
    • Organizer
      第47回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 幼小児期の気管支喘息難治化に対する喫煙の影響2007

    • Author(s)
      須崎康恵, 濱田薫, 木村弘ら
    • Organizer
      第47回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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