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Neuroendocrine differentiation from multipotent cancer stem cell in small cell lung cancer : elucidation of mechanisms and application to treatment

Research Project

Project/Area Number 19590926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

HORIO Yoshitsugu  Aichi Cancer Center Research Institute, 分子腫瘍学部, 研究員 (30344336)

Co-Investigator(Kenkyū-buntansha) OSADA Hirotaka  愛知県がんセンター(研究所), 分子腫癌学部, 室長 (30204176)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords小細胞肺癌 / 幹細胞 / 分化 / 転写因子
Research Abstract

EGFR-TKI長期投与した肺腺癌患者の経過中、原発の腺癌部に小細胞肺がんが発生。その切除標本の解析からEGFR遺伝子L858R変異を腺癌と小細胞肺癌に共通して認め、免疫染色検査で小細胞肺癌はEGFR遺伝子とNotch3遺伝子発現の消失とAsh1遺伝子発現陽性、腺癌は逆の染色パターンであった。肺癌幹細胞からの腺癌への分化と小細胞肺癌への分化を示す癌化過程を示す症例と考えられた。非小細胞肺癌の発ガンにおいてNotch-3は重要であるが、細胞株でRT-PCR法での発現とトポイソメラーゼII阻害剤の感受性との相関は見られなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Gefitinib for the treatment of non-small-cell lung cancer2009

    • Author(s)
      Hida T, Ogawa S, Park JC, Park JY, Shimizu J, Horio Y, Yoshida K
    • Journal Title

      Expert Rev Anticancer Ther. 9

      Pages: 17-35

    • Related Report
      2008 Final Research Report
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2008

    • Author(s)
      Shimizu J, Horio Y, Osada H, Hida T, Hasegawa Y, Shimokata K, Takahashi T, Sekido Y, Yatabe Y
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Final Research Report
  • [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation2008

    • Author(s)
      Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y, Hida T, Sekido Y
    • Journal Title

      Carcinogenesis 29

      Pages: 2139-2146

    • Related Report
      2008 Final Research Report
  • [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer2008

    • Author(s)
      Tatematsu A, Shimizu J, Murakami Y, Horio Y, Nakamura S, Hida T, Mitsudomi T, Yatabe Y
    • Journal Title

      Clin Cancer Res. 14

      Pages: 6092-6096

    • Related Report
      2008 Final Research Report
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity of cisplatin, carboplatin and gemcitabine in human lung can cer cell lines2008

    • Author(s)
      J Shimizu, Y Horio, H Osada, et al.
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation2008

    • Author(s)
      Yokoyama T, Osada H, Horio Y, Sekido Y
    • Journal Title

      Carcinogenesis 29

      Pages: 2139-2146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer2008

    • Author(s)
      Tatematsu A, Shimizu J, Murakami Y, Horio Y, ., Yatabe Y
    • Journal Title

      Clin Cancer Res 14

      Pages: 6092-6096

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic pro filing of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p322007

    • Author(s)
      Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y
    • Journal Title

      Cancer Sci. 98

      Pages: 438-446

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer2007

    • Author(s)
      Yoshida K, Yatabe Y, Park JY, Shimizu J, Horio Y, Matsuo K, Kosaka T, Mitsudomi T, Hida T
    • Journal Title

      J Thorac Oncol. 2

      Pages: 22-28

    • Related Report
      2008 Final Research Report
  • [Journal Article] Chest wall dissemination of nocardiosis after percutaneous transthoracic needle biopsy2007

    • Author(s)
      Shimamoto H, Inaba Y, Yamaura H, Sato Y, Kamiya M, Miyazaki M, Arai Y, Horio Y
    • Journal Title

      Cardiovasc Intervent Radiol. 30

      Pages: 797-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas2007

    • Author(s)
      Sakamoto H, Shimizu J, Horio Y, Ueda R, Takahashi T, Mitsudomi T, Yatabe Y
    • Journal Title

      J Pathol 212

      Pages: 287-94

    • Related Report
      2008 Final Research Report
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity of cisplatin, carboplatin and gemcitabine in human lung cancer cell lines

    • Author(s)
      J Shimizu, Y Horio, H Osada, et. al.
    • Journal Title

      Respirology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] mRNA expression of RanBP2 is unlikely to be associated with chemosensitivity of amrubicine (topoisomerase II inhibitor) in human lung cancer cell lines2008

    • Author(s)
      YOSHITSUGU HORIO, JUNICHI SHIMIZU, HIROTAKA OSADA, TOYOAKI HIDA, YOSHITAKA SEKIDO
    • Organizer
      癌学会
    • Related Report
      2008 Final Research Report
  • [Presentation] 小細胞肺癌におけるEGFR遺伝子変異の検討2007

    • Author(s)
      清水淳一、堀尾芳射, 他6人
    • Organizer
      肺癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity of cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2007

    • Author(s)
      YOSHITSUGU HORIO, JUNICHI SHIMIZU, HIROTAKA OSADA, TOYOAKI HIDA, YOSHINORI HASEGAWA, KAORU SHIMOKATA, TAKASHI TAKAHASHI, YOSHITAKA SEKIDO, YASUSHI YATABE
    • Organizer
      2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      San Francisco, California
    • Related Report
      2008 Final Research Report
  • [Presentation] 小細胞肺癌におけるEGFR遺伝子変異の検討2007

    • Author(s)
      清水淳市, 堀尾芳嗣, 小川紫都, 朴智栄, 吉田公秀, 樋田豊明
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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