Pathologic roles of MIF in the development and progression ofglomerulonephritis and therapeutic applicatoin of MIF inhibition

• Project/Area Number: 19590928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: SASAKI Satoshi Hokkaido University, 北海道大学病院, 講師 (70312345)
• Co-Investigator(Kenkyū-buntansha): ONODERA Shin 北海道大学, 大学院・医学研究科, 特任講師 (00359481)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 糸球体腎炎 / 腎不全 / サイトカイン / マクロフアージ遊走阻止因子 / CD74 / 慢性腎炎 / 情報伝達

Research Abstract

MIF(マクロファージ遊走阻止因子)は、自然免疫を司る上流因子として知られるが、最近様々な疾患の発症や進展に関わりが深い分子である事が数多く報告されている。本研究では、MIFが、MIF 受容体や幾つか関連分子(CD74 など)と結合した結果生まれる情報伝達が、腎臓疾患に関わる機構を明らかにする事を試みた。糸球体硬化症の動物モデルであるマウス腎症やシクロスポリン腎症のモデルを用いてMIF の腎炎における役割を研究を進める中、シクロスポリン腎症における新たな病態と治療法開発の可能性についても解明し得た。

Research Products

• [Journal Article] Effective and safetreatment with cyclosporine innephrotic children : a prospective, randomized multicenter trial (2008)
  • Author(s): Ishikura K、Sasaki S、Honda M、他
  • Journal Title: Kidney International 73 Pages: 1167-1173
  • Peer Reviewed
• [Journal Article] Pediatric kidneytransplantation is safe and availablefor patients with urological anomaliesas well as those with primary renaldiseases (2008)
  • Author(s): Morita K、Sasaki S、Nonomura K、他
  • Journal Title: Pediatric Transplantation 13 Pages: 200-205
  • Peer Reviewed
• [Journal Article] Active immunizationagainst macrophage migrationinhibitory factor using a nove dNAvaccine prevents ovariectomy-inducedbone loss in mice (2008)
  • Author(s): Onodera S、Oshima S、Koyama Y、他
  • Journal Title: Vaccine 26 Pages: 829-836
  • Peer Reviewed
• [Journal Article] Effective and safe treatment with cyclosporine in nephrotic children : a prospective, randomized multicenter trial (2008)
  • Author(s): Ishikura K, Ikeda M, Hattori S, Yoshikawa N, Sasaki S, et.al.
  • Journal Title: Kidney Int 73 Pages: 1167-1173
  • Peer Reviewed
• [Journal Article] Pediatric kidney transplantation is safe and available for patients with urological anomalies as well as those with primary renal diseases (2008)
  • Author(s): Morita K, Iwami D, Hotta K, Shimoda N, Sasaki S, et.al.
  • Journal Title: Pediatr Transplant 13 Pages: 200-205
  • NAID: 120005315202
  • Peer Reviewed
• [Journal Article] Effective and safe treatment with cyclosporine in nephrotic children: A prospective, randomized multicenter trial (2008)
  • Author(s): Ishikura K, Sasaki S, et. al.
  • Journal Title: Kidney Int (on line publication)
  • Peer Reviewed
• [Journal Article] 腎泌尿器疾患診療マニュアル小児から成人まで・主要症候・検査から腎尿路系疾患を見つけ出す・電解質異常Na・Clの異常(小児) (2007)
  • Author(s): 佐々木聡
  • Journal Title: 日本医師会雑誌 36
  • Peer Reviewed
• [Presentation] エリスロポエチン誘導体は、シクロスポリン腎症の進展を抑制し得る (2009)
  • Author(s): 伊東広臨、佐々木聡、岡本孝之、有賀正
  • Organizer: 第44回日本小児腎臓病学会
  • Place of Presentation: 東京都
  • Year and Date: 2009-06-26
• [Presentation] 重症ループスエリテマトーデス若年症例における低用量シクロフォスファミドパルス療法(EURO-Lupus)による寛解導入 (2008)
  • Author(s): 中島泰志、佐々木聡、伊東広臨、有賀正
  • Organizer: 第43回日本小児腎臓病学会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-06-13
• [Book] Annual Review 腎臓 2007(御手洗哲也ら編) (2007)
  • Author(s): 佐々木 聡
  • Total Pages: 308
  • Publisher: 微小変化型ネフローゼ症候群とポドサイトB7-1 protein