Molecular mechanism of the novel hormone/receptor systems in renal and cardiovascular dysfunction
Project/Area Number |
19590929
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Tohoku University |
Principal Investigator |
TOTSUNE Kazuhito Tohoku University, 大学院・薬学研究科, 准教授 (10217515)
|
Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazuhiro 東北大学, 大学院・医学系研究科, 教授 (80241628)
IMAI Yutaka 東北大学, 大学院・薬学研究科, 教授 (40133946)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 遺伝子 / 循環器 / 高血圧 / 生理活性因子 / 発現・制御 / 腎障害 / 循環器・高血圧 / 生理活性 |
Research Abstract |
最近発見されたホルモン/受容体系の腎障害・心血管障害における役割を検討した。腎不全・心不全動物モデルにてURP, AM2, (プロ)レニン受容体((P)RR)の発現が心臓または腎臓で変化すること、AM2の遺伝子多型は24hABP及び慢性腎疾患に関係し、(P)RRの遺伝子多型が24hABP、左室肥大、脳ラクナ梗塞と関連することを見いだした。これらホルモン/受容体系が実際に腎障害・心血管障害に関与していることが示された。
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Association of(pro)renin receptor gene polymorphism with blood pressure in Japanese men : the Ohasama study2009
Author(s)
Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y
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Journal Title
Am J Hypertens 22
Pages: 294-299
Related Report
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[Journal Article] Associatidn of (pro)renin receptor gene polymorphism with blood pressure in Japanese men : the Ohasama study2009
Author(s)
Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y.
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Journal Title
Am J Hypertens 22
Pages: 294-299
Related Report
Peer Reviewed
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[Journal Article] Day-by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis : the Ohasama study2008
Author(s)
Kikuya M, Ohkubo T, Metoki H, Asayama K, Hara A, Obara T, Inoue R, Hoshi H, Hashimoto J, Totsune K, Satoh H, Imai Y
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Journal Title
Hypertension 52
Pages: 1045-1050
Related Report
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[Journal Article] Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure2008
Author(s)
Hirose T, Totsune K, Mori N, Morimoto R, Hashimoto M, Nakashige Y, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Sasano H, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Eur J Heart Fail 10
Pages: 840-849
Related Report
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[Journal Article] Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues2008
Author(s)
Morimoto R, Satoh F, Murakami O, Hirose T, Totsune K, Imai Y, Arai Y, Suzuki T, Sasano H, Ito S, Takahashi K
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Journal Title
J Endocrinol 198
Pages: 175-183
Related Report
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[Journal Article] Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study2008
Author(s)
Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y
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Journal Title
Am J Hypertens 21
Pages: 413-418
Related Report
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[Journal Article] Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure2008
Author(s)
Nakayama T, Hirose T, Totsune K, Mori N, Maruyama Y, Maejima T, Minagawa K, Morimoto R, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Kohzuki M, Takahashi K, Imai Y
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Journal Title
Peptides 29
Pages: 801-808
Related Report
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[Journal Article] Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure2008
Author(s)
Hirose T, Totsune K, Mori N, Morimoto R, Hashimoto M, Nakashige Y, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto I, Sasano H, Kohzuki M, Takahashi K, Imai Y.
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Journal Title
Eur J Heart Fail 10
Pages: 840-849
Related Report
Peer Reviewed
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[Journal Article] Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues2008
Author(s)
Morimoto R, Satoh F, Murakami O, Hirose T, Totsune K, Imai Y, Arai Y, Suzuki T, Sasano H, Ito S, Takahashi K.
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Journal Title
J Endocrinol 198
Pages: 175-183
Related Report
Peer Reviewed
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[Journal Article] Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure.2008
Author(s)
Nakayama T, Hirose T, Totsune K, Mori N, Maruyama Y, Maejima T, Minagawa K, Morimoto R, Asayama K, Kikuya M, Ohkub T, HashimoJ, Kohzuki M, Takabashi K, Imai Y.
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Journal Title
Peptides 29(Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama studa.2008
Author(s)
Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y.
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Journal Title
Am J Hypertens 21
Pages: 413-418
Related Report
Peer Reviewed
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[Journal Article] Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population-the Ohasama study2007
Author(s)
Nakayama M, Metoki H, Terawaki H, Ohkubo T, Kikuya M, Sato T, Nakayama K, Asayama K, Inoue R, Hashimoto J, Totsune K, Hoshi H, Ito S, Imai Y
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Journal Title
Nephrol Dial Transplant 22
Pages: 1910-1915
Related Report
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[Journal Article] Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese Population-the Ohasama study.2007
Author(s)
Nakayama M, Metoki H, Terawaki H, Ohkubo T, Kikuya M, Sato T, Nakayama K, Asayama K, Inoue R, Hashimoto J, Totsune K, Hoshi H, Ito S, Imai Y.
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Journal Title
Nephrol Dial Transplant 22
Pages: 1910-1915
Related Report
Peer Reviewed
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[Presentation] Decreased expression of adrenomedullin 2 in the kidney of rats with hypertension or chronic renal failure. The American Society of Nephrology2008
Author(s)
Totsune K, Hirose T, Mori N, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K, Imai Y
Organizer
41^<st> Annual Meeting
Place of Presentation
Philadelphia, USA
Year and Date
2008-11-08
Related Report
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[Presentation] Decreased expression of adrenomedullin 2 in the kidney of rats with hypertension or chronic renal failure2008
Author(s)
Totsune K, Hirose T, Mori N, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K, Imai Y.
Organizer
The American Society of Nephrology, 41^<st> Annual Meeting
Place of Presentation
Philadelphia, USA
Year and Date
2008-11-08
Related Report
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[Presentation] Adrenomedullin 2 gene I/D polymorphism is associated with blood pressure, renal function, and proteinuria in a Japanese general population: the Ohasama study. The American Society of Nephrology2008
Author(s)
Totsune K, Hirose T, Nakashige Y, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K, Imai Y
Organizer
41^<st> Annual Meeting
Place of Presentation
Philadelphia, USA
Year and Date
2008-11-06
Related Report
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[Presentation] Adrenomedullin 2 gene I/D polymorphism is associated with blood pressure, renal function, and proteinuria in a Japanese general population : the Ohasama study2008
Author(s)
Totsune K, Hirose T, Nakashige Y, Metoki H, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K. Imai Y.
Organizer
The American Society of Nephrology, 41^<st> Annual Meeting
Place of Presentation
Philadelphia, USA
Year and Date
2008-11-06
Related Report
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[Presentation] Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues2008
Author(s)
Morimoto R, Satoh F, Murakami O, Hirose T, Totsune K, Imai Y, Arai Y, Suzuki T, Sasano H, Ito S, Takahashi K
Organizer
22^<nd> Scientific Meeting of International Society of Hypertension Hypertension Berlin 2008
Place of Presentation
Berlin, Germany
Year and Date
2008-05-14
Related Report
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[Presentation] Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues2008
Author(s)
Morimoto R, Satoh F, Murakami O, Hirose T, Totsune K, Imai Y, Arai Y, Suzuki T, Sasano H, Ito S, Takahashi K.
Organizer
22^<nd> Scientific Meeting of International Society of Hypertension. Hypertension Berlin 2008
Place of Presentation
Berlin, Germany
Year and Date
2008-05-14
Related Report
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[Presentation] Renal gene expression of(pro)renin receptor: Upregulation in rats with chronic renal failure. The American Society of Nephrology2007
Author(s)
Totsune K, Hirose T, Maejima T, Mori N, Maruyama Y, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K, Imai Y
Organizer
40th Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
2007-11-03
Related Report
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[Presentation] Renal gene expression of (pro) renin receptor: Upregulation in rats with chronic renal failure.2007
Author(s)
Totsune K, Hirose T, Maejima T, Mori N, Maruyama Y, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Takahashi K, Imai Y
Organizer
The American Society of Nephrology, 40th Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
2007-11-03
Related Report
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