Urinary L-FABP ; A Biomarker for Kidney Diseases

• Project/Area Number: 19590935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: NOIRI Eisei The University of Tokyo, 医学部・附属病院, 准教授 (00301820)
• Co-Investigator(Kenkyū-buntansha): SUGAYA Takeshi 東京歯科大学, 歯学部, 非常勤講師 (40381561)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 腎臓学 / 疾患管理

Research Abstract

今回、新規マウス慢性腎不全(CKD)モデルを確立するとともに、2つの急性腎不全(AKI)モデルについて検討し、いずれにおいても尿中L 型脂肪酸結合蛋白(L-FABP)は腎疾患を早期から既存のマーカーよりも高精度で診断できる有用な新規バイオマーカーであること、AKI、CKDいずれにおいても尿中L-FABPは腎疾患の治療効果もモニタリングできるバイオマーカーであること、尿中L-FABP は血中レベルとは異なり、腎障害時に近位尿細管から管腔中へ放出される尿細管ストレス感知分子であること、腎尿細管でのL-FABP 発現は尿細管自体のViability を示すこと、さらにL-FABP は腎での酸化ストレス・脂質毒性(lipotoxicity)を尿中へ排出することで腎障害を減弱させる腎保護蛋白であることを確認した。

Research Products

• [Journal Article] Urinary fatty acid-bindingprotein 1 : an early predictivebiomarker of kidney injury (2009)
  • Author(s): Noiri E, Doi K, Negishi K, Tanaka T,Hamasaki Y, Fujita T, Portilla D,Sugaya T
  • Journal Title: Am J Physiol Renal Physiol 296
  • Peer Reviewed
• [Journal Article] Urinary L-typefatty acid-binding protein canreflect renal tubulointerstitialinjury (2009)
  • Author(s): Tanaka T, Doi K, Maeda-Mamiya R,Negishi K, Portilla D, Sugaya T,Fujita T, Noiri E
  • Journal Title: Am J Pathol 174 Pages: 1203-11
  • Peer Reviewed
• [Journal Article] Monitoring of urinary L-typefatty acid-binding protein predictshistological severity of acute kidneyinjury (2009)
  • Author(s): Negishi K, Noiri E, Doi K,Maeda-Mamiya R, Sugaya T, Portilla D,Fujita T
  • Journal Title: Am J Pathol 174 Pages: 1154-9
  • Peer Reviewed
• [Journal Article] Contribution of Tlymphocytes to rat renalischemia/reperfusion injury (2009)
  • Author(s): Noiri E, Doi K, Inagi R, Nangaku M,Fujita T
  • Journal Title: Clin ExpNephrol 13 Pages: 25-32
  • NAID: 10025585641
  • Peer Reviewed
• [Journal Article] Urinary fatty acid-binding protein 1:an early predictive biomarker of kidney injury. (2009)
  • Author(s): Noiri E, Doi K, Negishi K, Tanaka T, Hamasaki Y, Fujita T, Portilla D, Sugaya T
  • Journal Title: Am J phsiol Renal Physiol 296
  • Peer Reviewed
• [Journal Article] Urinary L-type fatty acid-binding Protein can reflect renal tubulointerstitial injury. (2009)
  • Author(s): 9. TanaKa T, Doi K, Maeda-Mamiya R, Negishi K, Portilla D, Sugaya T, Fujita T, Noiri F
  • Journal Title: Am J Pathol 174 Pages: 1203-1211
  • Peer Reviewed
• [Journal Article] Monitoring of urinary L type fatty acid-binding protein predicts histolegioal severity of acute kidney injury. (2009)
  • Author(s): 8. Negishi K, Noiri E, Doi K, Maeda-Mamiya R, Sugaya T, Poilla D, Fujita T
  • Journal Title: Am J Pathol 174 Pages: 1154-1159
  • Peer Reviewed
• [Journal Article] Renal L-typefatty acid-binding protein mediatesthe bezafibrate reduction ofcisplatin-induced acute kidney injury (2008)
  • Author(s): Negishi K, Noiri E, Maeda R, PortillaD, Sugaya T, Fujita T
  • Journal Title: Kidney Int 73 Pages: 1374-84
  • Peer Reviewed
• [Journal Article] Genome study of kidneydisease in the age of postgenome-sequencing (2008)
  • Author(s): Doi K, Okamoto K, Tokunaga K, FujitaT, Noiri E
  • Journal Title: Endocr MetabImmune Disord Drug Targets 8 Pages: 173-83
  • Peer Reviewed
• [Journal Article] Functional polymorphism of themyeloperoxidase gene in hypertensivenephrosclerosis dialysis patients (2008)
  • Author(s): Doi K, Noiri E, Maeda R, Nakao A,Kobayashi S, Tokunaga K, Fujita T
  • Journal Title: Hypertens Res 30 Pages: 1193-8
  • Peer Reviewed
• [Journal Article] Urinaryhuman L-FABP is a potential biomarkerto predict COX-inhibitor-inducedrenal injury (2008)
  • Author(s): Tanaka T, Noiri E, Yamamoto T, SugayaT, Negishi K, Maeda R, Nakamura K,Portilla D, Goto M, Fujita T
  • Journal Title: Nephron Exp Nephrol 108
  • Peer Reviewed
• [Journal Article] AKI-新時代の幕開け[Editorial] (2008)
  • Author(s): 野入英世
  • Journal Title: 内科 Pages: 2-4
  • Peer Reviewed
• [Journal Article] AKI の早期診断・早期治療にむけて (2008)
  • Author(s): 野入英世、伊西洋二、塚原宏一、菅谷健
  • Journal Title: 内科 Pages: 115-124
  • Peer Reviewed
• [Journal Article] Urinary human L-FABP is a potential biomarker to predict COX-inhibitor-induced renal injury (2008)
  • Author(s): Tanaka T, Noiri E, Yamamoto T, Sugaya T, Negishi K, Maeda R, Nakamura K, Portilla D Goto M Fujita T
  • Journal Title: Nephron Exp Nephrol 108
  • Peer Reviewed
• [Journal Article] Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney (2008)
  • Author(s): Negishi K, Noiri E, Maeda R, Portilla D, Sugaya T, Fujita T
  • Journal Title: Kidney Int 73 Pages: 1374-1384
  • Peer Reviewed
• [Journal Article] Genome study of kidney disease in the age of post genome-sequencing (2008)
  • Author(s): Doi K, Okamoto K, Tokunaga K, Fujita T, Noiri E
  • Journal Title: Endocr Metab Immune Disord Drug Targets 8 Pages: 173-183
  • Peer Reviewed
• [Journal Article] Liver fatty acid-bindingprotein as a biomarker of acute kidneyinjury after cardiac surgery (2007)
  • Author(s): Portilla D, Dent C, Sugaya T, NagothuKK, Kundi I, Moore P, Noiri E,Devarajan P
  • Journal Title: Kidney Int 73 Pages: 465-72
• [Journal Article] Renal L-type fattyacid-binding protein in acuteischemic injury (2007)
  • Author(s): Yamamoto T, Noiri E, Ono Y, Doi K,Negishi K, Kamijo A, Kimura K, FujitaT, Kinukawa T, Taniguchi H, NakamuraK, Goto M, Shinozaki N, Ohshima S,Sugaya T
  • Journal Title: JASN 18 Pages: 2894-902
• [Presentation] 尿中脂肪酸結合蛋白1(FABP1)での急性腎不全後の腎機能回復予測 (2009)
  • Author(s): 根岸康介, 野入英世, 浜崎敬文, 土井研人, 本田謙次郎, 小林修三, 藤田敏郎
  • Organizer: 第106回日本内科学会講演会
  • Place of Presentation: 東京
• [Presentation] Role of L-Type Fatty Acid Binding Protein in sepsis and Sepsis-Induced Acute Kidney Injury. (2008)
  • Author(s): Ken Doi, Eisei Noin, Kousuke Negishi, Yoshifumi Hamasaki, Toshiro Fujita, Hikaru Koide Tsukasa Nakamura
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: Philadelphia Convention
  • Year and Date: 2008-11-07
• [Presentation] UrinaryL-FABP Can Predict the Recovery of RenalFunction after AKI (2008)
  • Author(s): Yoshifumi Hamasaki, Kousuke Negishi, Eisei Noiri, Kent Doi, Kenjiro Honda, Takayasu Ohtake, Shuzo Kobayashi, Takeshi Sugaya, Toshiro Fujita
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: フィラデルフィア
• [Presentation] Role of L-Type Fatty AcidBinding Protein in Sepsis andSepsis-Induced Acute Kidney Injury (2008)
  • Author(s): Kent Doi, Eisei Noiri, Kousuke Negishi, Yoshifumi Hamasaki, Toshiro Fujita, Hikaru Koide, Tsukasa Nakamura, Takeshi Sugaya
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: フィラデルフィア
• [Presentation] Monitoring of Urinary L-TypeFatty Acid Binding Protein PredictsHistological Severity of Acute Kidney Injury (2008)
  • Author(s): Kousuke Negishi, Eisei Noiri, Kent Doi, Koji Okamoto, Takeshi Sugaya, Toshiro Fujita
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: フィラデルフィア
• [Presentation] Acute Kidney Injury における尿中Biomarkerとしての肝臓型脂肪酸結合蛋白(L-FABP)の有用性 (2008)
  • Author(s): 根岸康介, 野入英世, 菅谷健, 田中珠美, 岡本好司, 藤田敏郎
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
• [Presentation] 小児心臓手術術後急性腎不全発見に対する尿中L-FABPの有用性について (2008)
  • Author(s): 菅谷健, Didier Portilla, 野入英世
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
• [Presentation] 尿中L-FABPの経時的変化はAKI後の腎機能改善の予測の指標となりうる (2008)
  • Author(s): 浜崎敬文, 根岸康介, 野入英世, 土井研人, 本田謙次郎, 大竹剛靖, 小林修三, 藤田敏郎
  • Organizer: 第38回日本腎臓学会東部学術大会
  • Place of Presentation: 福岡
• [Presentation] A Sensitive Biomarker of AKI : Monitoring of Urinary L-Type Fatty Acid Binding Protein (L-FABP) (2007)
  • Author(s): Kousuke Negishi, Eisei Noiri, Rul Maeda, Tamami Tanaka, Koji Okamoto, Takeshi Sugava Toshiro Fujita
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: San Diego Convention Ctr
  • Year and Date: 2007-11-04
• [Presentation] A Sensitive Biomarker of AKI : Monitoringof Urinary L-Type Fatty Acid Binding Protein(L-FABP) (2007)
  • Author(s): Kousuke Negishi, Eisei Noiri, RuiMaeda ,Tamami Tanaka, Koji Okamoto, Takeshi Sugaya, Toshiro Fujita
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: サンフランシスコ
• [Presentation] Urinary L-Type FattyAcid Binding Protein(L-FABP)is aSensitive Biomarker in Adenine inducedMice Cardiorenal Anemia Syndrome(CRAS)Model (2007)
  • Author(s): Tamami Tanaka, Eisei Noiri, KousukeNegishi, Rui Maeda, Takeshi Sugaya, Toshiro Fujita
  • Organizer: American Society of Nephrology Renal Week
  • Place of Presentation: サンフランシスコ
• [Book] Annual Review 腎臓 2009 (2009)
  • Author(s): 根岸康介
  • Total Pages: 10
  • Publisher: 中外医学社
• [Book] AKI シラバス内科 (2008)
  • Author(s): 野入英世監修
  • Publisher: 南江堂・東京
• [Remarks] 本報告書の著作権は、文部科学省及び独立大学法人東京大学に帰属しており、本報告書の全部又は一部の無断複製等の行為は、法律で認められた場合を除き、著作権の侵害にあたるため、これらの利用行為を行うときは承認手続きを要する。