• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Where is the cause of Bartter's syndrome in the kidney?

Research Project

Project/Area Number 19590936
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

WATANABE Sumiyo  The University of Tokyo, 医学部附属病院, 医員 (30422314)

Co-Investigator(Kenkyū-buntansha) SAITO Taku  東京大学, 医学部附属病院, 特任助教 (30456107)
池田 敏之  東京大学, 医学部附属病院, 医員 (80322759)
小笠原 徹  東京大学, 医学部附属病院, 講師 (20359623)
内田 俊也  帝京大学, 医学部附属病院, 教授 (50151882)
Co-Investigator(Renkei-kenkyūsha) IKEDA Tosiyuki  東京大学, 医学部附属病院, 助教 (80322759)
OGASAWARA Toru  東京大学, 医学部附属病院, 講師 (20359623)
UCHIDA Shunya  帝京大学, 医学部, 教授 (50151882)
SUZUKI Nobuchika  東京大学, 先端科学技術研究センター, 特任助教 (90247007)
HONDA Zenitiro  東京大学, 医学部附属病院, 講師 (70238814)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバーター症候群 / カルシウム代謝 / 腎機能低下 / 副甲状腺機能低下症 / Ca感知受容体 / 腎電解質異常 / 低Ca血症 / 慢性腎不全 / 骨異栄養症 / 遺伝子治療 / 遺伝子治療3 / カルシウム感知受容体 / 腎電解質代謝 / 低カルシウム血症 / 高カリウム血症 / 高リン血症
Research Abstract

We developed the expression method using tissue-specific promoters and it resulted in site-specific EGFP expression within the kidney. Adenovirus expression could be limited to the thick ascending limb of Henle (TALH), proximal tubules, or collecting ducts of the kidney without causing liver expression or kidney damage. We investigated it using GFP protein, and next, we tend to express calcium-sensing receptor.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 2007

All Journal Article (21 results) (of which Peer Reviewed: 21 results)

  • [Journal Article] Tumor-induced osteomalacia associated with a maxillofacial tumor producing fibroblast growth factor 23 : report of a case and review of the literature2010

    • Author(s)
      Mori Y, Ogasawara T, et.al.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109(3)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The optimization of porous polymeric scaffolds for chondrocyte/atelocollagen based tissue-engineered cartilage2010

    • Author(s)
      Tanaka Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T, Asawa Y, Fujihara Y, Takato T, Hoshi K.
    • Journal Title

      Biomaterials 31(16)

      Pages: 4506-16

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development2010

    • Author(s)
      Saito T, et.al.
    • Journal Title

      Nat Med. 16(6)(Epub)

      Pages: 678-86

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, et.al.
    • Journal Title

      Arthritis Rheum. 62(3)

      Pages: 826-36

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells2010

    • Author(s)
      Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, et.al.
    • Journal Title

      J Cell Biochem. 109(4)

      Pages: 755-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aptitude of auricular and nasoseptal chondrocytes cultured under a monolayer or three-dimensional condition for cartilage tissue engineering2009

    • Author(s)
      Asawa Y, Ogasawara T, et.al.
    • Journal Title

      Tissue Eng Part A 15(5)

      Pages: 1109-18

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER : identification of sorting nexin 19 as a novel factor2009

    • Author(s)
      Kan A, Ikeda T, Saito T, et.al.
    • Journal Title

      Arthritis Rheum. 60(11)

      Pages: 3314-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p572009

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, et.al.
    • Journal Title

      PLoS One. 4(2)(Epub)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene2009

    • Author(s)
      Higashikawa A, Saito T, Ikeda T, et.al.
    • Journal Title

      Arthritis Rheum. 60(1)

      Pages: 166-78

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p572009

    • Author(s)
      Hirata M, Ogasawara T, Ikeda T, et.al
    • Journal Title

      PLoS One. 4(2)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of chondrogenic factors with a real-time fluoresce nce-monitoring cell line ATDC5-C2ER : identification of sorting nexin 19 as a novel factor2009

    • Author(s)
      Kan A, Ikeda T, Ogasawara T., et.al
    • Journal Title

      Arthritis Rheum. Nov ; 60(11)

      Pages: 3314-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria2009

    • Author(s)
      Nosaka H, Uchida S, et.al
    • Journal Title

      J Nephrol. Jul-Aug ; 22(4)

      Pages: 484-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, et.al.
    • Journal Title

      Dev Cell. 14(5)

      Pages: 689-99

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor contents of autologous human sera prepared by different production methods and their biological effects on chondrocytes2008

    • Author(s)
      Tanaka Y, Ogasawara T, et.al.
    • Journal Title

      Cell Biol Int. 32(5)(Epub)

      Pages: 505-14

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes2008

    • Author(s)
      Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, et.al.
    • Journal Title

      J Clin Invest. 118(7), Erratum in 118(8)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator2008

    • Author(s)
      Tamiya H, Ikeda T, Jeong JH, Saito T, et.al.
    • Journal Title

      Gene. 416(1-2)(Epub)

      Pages: 53-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional microenvironments retain chondrocyte phenotypes during proliferation culture2007

    • Author(s)
      Takahashi T, Ogasawara T, et.al.
    • Journal Title

      Tissue Eng. 13(7)

      Pages: 1583-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes2007

    • Author(s)
      Liu G, Kawaguchi H, Ogasawara T, et.al.
    • Journal Title

      J Biol Chem. 282(28)(Epub)

      Pages: 20407-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in osteoblasts and osteoclasts controls bone remodeling2007

    • Author(s)
      Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, et.al.
    • Journal Title

      PLoS One. 2(10)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of the human SOX6 promoter2007

    • Author(s)
      Ikeda T, Saito T, et.al.
    • Journal Title

      Biochem Biophys Res Commun. 357(2)(Epub)

      Pages: 383-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes2007

    • Author(s)
      Saito T, Ikeda T, et.al.
    • Journal Title

      EMBO Rep. 8(5)(Epub)

      Pages: 504-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi