Role of Basigin-VEGF/NO signal in the diabetic nephropathy
| Project/Area Number |
19590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
YUZAWA Yukio Nagoya University, 大学院・医学系研究科, 講師 (00191479)
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| Co-Investigator(Kenkyū-buntansha) |
NIKI Ichiro 大分大学, 医学部, 教授 (10262908)
松尾 清一 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
門松 健治 名古屋大学, 大学院・医学系研究科, 教授 (80204519)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Seiichi 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
KADOMATSU Kenji 名古屋大学, 大学院・医学系研究科, 教授 (80204519)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病性腎症 / ベイシジン / VEGF / NO uncoupling / microinflammation / Basigin / E-selectin / VEGF-Ainduce / バイオマーカー / eNOS / 尿細管・間質障害 / 硫化水素 |
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| Research Abstract |
糖尿病性腎症の発症機序におけるBasigin-VEGF/NOシグナルの関与について検討した結果、初期段階からVEGF/NO uncouplingにより、血管新生が引き起こされる。また、Basiginは、VEGFのinducerとしては作用せず、Basigin上の糖鎖がE-selectinの新たなリガンドとして働き、糸球体内へのmicroinflammationを誘導し、糖尿病性腎症の発症・進展に関与する。
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Report
(3 results)
Research Products
(95 results)
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[Journal Article] Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue2008
Author(s)
Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S
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Journal Title
Stem Cells and Development (in press)
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[Journal Article] Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis2008
Author(s)
Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
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Journal Title
Nephrology dialysis transplantation (in press)
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[Journal Article] Prevalence of Pancreatic Cystic Lesions Including Intraductal Papillary Mucinous Neoplasms in Patients With End-Stage Renal Disease on Hemodialysis2008
Author(s)
Ishikawa T, Takeda K, Itoh M, Imaizumi T, Oguri K, Takahashi H, Kasuga H, Toriyama T, Matsuo S, Hirooka Y, Itoh A, Kawashima H, Kasugai T, Ohno E, Miyahara R, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Goto H
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[Journal Article] Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients2008
Author(s)
Shoichi Maruyama, Akihiko Taguchi, Shigejiro Iwashima, Takenori Ozaki, Kaoru Yasuda, Akie Kikuchi-Taura, Toshihiro Soma, Hideki Ishii, Toyoaki Murohara, Hiroshi Takahashi, Hirotake Kasuga, Yoshitaka Kumada, Takanobu Toriyama, Yasuhiko Ito, Hirohisa Kawahara, Yukio Yuzawa and Seiichi Matsuo
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Journal Title
Kidney international 74(12)
Pages: 1603-9
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[Journal Article] Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease2008
Author(s)
Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T
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Journal Title
Nephrology dialysis transplantation 23(12)
Pages: 3996-4001
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[Journal Article] Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy2008
Author(s)
Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S
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Journal Title
Journal of the American Society of Nephrology 19(9)
Pages: 1701-1711
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[Journal Article] Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease2008
Author(s)
Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
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Journal Title
Clinical journal of the American Society of Nephrology 3(4)
Pages: 1034-1040
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[Journal Article] A Serine/Threonine Kinase, Cot/Tpl2, Regulates Renal Cell Apoptosis in Ischemia/Reperfusion Injury2008
Author(s)
Takaaki Yaomura, Naotake Tsuboi, Yoshinori Urahama, Akinori Hobo, Kenji Sugimoto, Jun Miyoshi, Tetsuya Matsuguchi, Kannagi Reiji, and Seiichi Matsuo, Yukio Yuzawa
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Journal Title
Nephrology 13(5)
Pages: 397-404
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[Journal Article] Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis2008
Author(s)
Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T, Uetani T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
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Journal Title
Circulation journal 72(1)
Pages: 56-60
NAID
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[Journal Article] The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy2008
Author(s)
Sato W, Kosugi T, Zhang L, Roncal CA, Heinig M, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Grant MB, Croker BP, Nakagawa T
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Journal Title
Laboratory investigation 88(9)
Pages: 949-961
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[Journal Article] High mobility group box chromosomal protein 1 in patients with renal diseases2008
Author(s)
Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo
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Journal Title
Nephron Clinical Practice 108(3)
Pages: 194-201
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Peer Reviewed
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[Journal Article] Efficacy of oral nicorandil in patients with end-stage renal disease: A retrospective chart review after coronary angioplasty in japanese patients receiving hemodialysis2007
Author(s)
Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S,Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T
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Journal Title
Clinical therapeutics 29(1)
Pages: 110-122
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Peer Reviewed
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[Presentation] eNOS Deficiency as a Mechanism for Development of Mesangiolysis, Glomerular Microaneurysms and Nodular Glomerulosclerosis in the Mouse Kidney2007
Author(s)
W Sato, M Heinig, C Roncal, Y Yuzawa, Mu Wei, S Reungjui, Michael S. Gersch, Byron Croker, Seiichi Matsuo, Richard J. Johnson, Takahiko Nakagawa
Organizer
40rd Annual Meeting of The American Society of Nephrology
Place of Presentation
San Francisco
Related Report
