A new paradigm for the kidney regenerative medicine using adipose derived cells

• Project/Area Number: 19590948
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: MARUYAMA Shoichi Nagoya University, 医学部・附属病院, 講師 (10362253)
• Co-Investigator(Kenkyū-buntansha): 湯澤 由紀夫 名古屋大学, 大学院・医学系研究科, 講師 (00191479) ; 田口 明彦 国立循環器病センター, 循環動態機能部, 室長 (10359276) ; 菅谷 健 東京歯科大学, 歯学部, 客員講師 (40381561) ; 松尾 清一 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
• Co-Investigator(Renkei-kenkyūsha): YUZAWA Yukio 名古屋大学, 大学院・医学系研究科, 講師 (00191479) ; TAGUCHI Akihiko 国立循環器病センター, 循環動態機能部, 室長 (10359276) ; SUGAYA Takeshi 東京歯科大学, 歯学部, 客員講師 (40381561) ; MATSUO Seiichi 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 脂肪由来幹細胞 / 間葉系幹細胞 / 低血清培養 / サイトカイン / 下肢虚血 / 腎再生 / 急性腎不全 / 再生医療 / 脂肪 / 慢性腎臓病 / 急性腎障害

Research Abstract

本研究の目的は「脂肪由来幹細胞を用いた新たな腎再生医療を開発すること」である. 低血清培養脂肪由来MSCは高血清で培養したMSCと比較して、再生促進サイトカイン(VEGF, HGF)を多く分泌することを介して、血管内皮細胞の増殖を促進し、アポトーシスを抑制することを見出した.また低血清培養脂肪由来MSCをラットの下肢虚血モデルに投与すると高血清培養MSCと比較してより強い再生促進効果が得られた.さらに、急性腎不全を惹起したラットの腎被膜下に低血清培養MSCもしくは培養を介さない脂肪由来細胞を投与することで腎障害が軽減されることを見出した.

Research Products

• [Journal Article] Kidoney regeneration through nephron neogenesis in medaka (2009)
  • Author(s): Naoki Watanabe, Mitsuhiro Kato, Norihiko Suzuki, Chikako Inoue, Svetlana Fedorova, HisashiHashimoto, Shoichi Maruyama, Seiichi Matsuo and Yuko Wakamatsu
  • Journal Title: Development Growth and Differentiation 51 Pages: 135-143
  • Peer Reviewed
• [Journal Article] Kidoney regeneration through nephron neogenesis in medaka. (2009)
  • Author(s): Naoki Watanabe
  • Journal Title: Development Growth and Differentiation 51 Pages: 135-143
  • Peer Reviewed
• [Journal Article] Efficiency of laparoscopic-assisted renal biopsy (2008)
  • Author(s): Anas CM, Hattori R, Morita Y, Matsukawa Y, Komatsu, T, Yoshino Y, Maruyama S, Yuzawa Y., Matsuo S and Gotoh M
  • Journal Title: Clinical Nephrology 70(3) Pages: 203-9
  • Peer Reviewed
• [Journal Article] Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue (2008)
  • Author(s): Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S
  • Journal Title: Stem Cells and Development (in press)
  • Peer Reviewed
• [Journal Article] Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis (2008)
  • Author(s): Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T
  • Journal Title: Nephrology dialysis transplantation (in press)
  • Peer Reviewed
• [Journal Article] Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-ss-galactosidase (Abase) for ABO incompatible transplantation (2008)
  • Author(s): Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Iwamoto M, Kuzuya T, Kadomatsu K, Uchida K, Nakao A
  • Journal Title: Transplant immunology Jan 20(3) Pages: 132-8
  • Peer Reviewed
• [Journal Article] Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis (2008)
  • Author(s): Urahama Y, Ohsaki Y, Fujita Y,Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T
  • Journal Title: Ameircan journal of Pathology 173(5) Pages: 1286-1294
  • Peer Reviewed
• [Journal Article] Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients (2008)
  • Author(s): Shoichi Maruyama, Akihiko Taguchi, Shigejiro Iwashima, Takenori Ozaki, Kaoru Yasuda, Akie Kikuchi-Taura, Toshihiro Soma, Hideki Ishii, Toyoaki Murohara, Hiroshi Takahashi, Hirotake Kasuga, Yoshitaka Kumada, Takanobu Toriyama, Yasuhiko Ito, Hirohisa Kawahara, Yukio Yuzawa and Seiichi Matsuo
  • Journal Title: Kidney international 74(12) Pages: 1603-9
  • Peer Reviewed
• [Journal Article] Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease (2008)
  • Author(s): Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T
  • Journal Title: Nephrology dialysis transplantation 23(12) Pages: 3996-4001
  • Peer Reviewed
• [Journal Article] Chronic kidney disease in Asia (2008)
  • Author(s): Imai E, Matsuo S
  • Journal Title: LANCET 371(9631) Pages: 2147-2148
  • Peer Reviewed
• [Journal Article] Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy (2008)
  • Author(s): Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S
  • Journal Title: Journal of the American Society of Nephrology 19(9) Pages: 1701-1711
  • Peer Reviewed
• [Journal Article] Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. American journal of physiology (2008)
  • Author(s): Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S
  • Journal Title: Renal physiology 294 Pages: 1084-1093
  • Peer Reviewed
• [Journal Article] A Serine/Threonine Kinase, Cot/Tpl2, Regulates Renal Cell Apoptosis in Ischemia/Reperfusion Injury (2008)
  • Author(s): Takaaki Yaomura, Naotake Tsuboi, Yoshinori Urahama, Akinori Hobo,Kenji Sugimoto, Jun Miyoshi,Tetsuya Matsuguchi, Kannagi Reiji, and Seiichi Matsuo, Yukio Yuzawa
  • Journal Title: Nephrology 13(5) Pages: 397-404
  • Peer Reviewed
• [Journal Article] The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy (2008)
  • Author(s): Sato W, Kosugi T, Zhang L, Roncal CA, Heinig M, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Grant MB, Croker BP, Nakagawa T
  • Journal Title: Laboratory investigation 88(9) Pages: 949-961
  • Peer Reviewed
• [Journal Article] In vivo silencing of a molecular target by short interfering RNA electroporation s : tumor vascularization correlates to delivery efficiency (2008)
  • Author(s): Takei Y, Nemoto T, Mu P, Fujishima T, Ishimoto T, Hayakawa Y, Yuzawa Y, Matsuo S, Muramatsu T, Kadomatsu K
  • Journal Title: Molecular cancer therapeutics 7(1) Pages: 211-221
  • Peer Reviewed
• [Journal Article] Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure (2008)
  • Author(s): Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S
  • Journal Title: Nephrology dialysis transplantation 23(1) Pages: 110-119
  • Peer Reviewed
• [Journal Article] Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hepten-induced contact hypersensitivity (2008)
  • Author(s): Takuji Ishimoto, Yoshifumi Takei, Yukio Yuzawa, Koji Hanai, Shunji Nagahama, Yuzo Tarumi, Seiichi Matsuo, Kenji Kadomatsu
  • Journal Title: Molecular Therapy 16(2) Pages: 387-395
  • Peer Reviewed
• [Journal Article] High mobility group box chromosomal protein 1 in patients with renal diseases (2008)
  • Author(s): Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo
  • Journal Title: Nephron Clinical Practice 108(3) Pages: 194-201
  • Peer Reviewed
• [Journal Article] High mobility group box chromosomal protein 1 in patients with renal diseases. (2008)
  • Author(s): Fumihiko Sato
  • Journal Title: Nephron Clinical Practice 108(3)
  • Peer Reviewed
• [Journal Article] Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hepten-induced contact hypersensitivity. (2008)
  • Author(s): Takuji Ishimoto
  • Journal Title: Molecular Therapy 16(2) Pages: 387-395
  • Peer Reviewed
• [Journal Article] Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. (2008)
  • Author(s): Ozaki T
  • Journal Title: Nephrology dialysis transplantation 23(1) Pages: 110-119
  • Peer Reviewed
• [Journal Article] In vivo silencing of a molecular target by short interfering RNA electroporation : tumor vascvilarization correlates to delivery efficiency. (2008)
  • Author(s): Takei Y
  • Journal Title: Molecular cancer therapeutics 7(1) Pages: 211-221
  • Peer Reviewed
• [Journal Article] Chronic kidney disease perspectives in Japan and the importance of urinalysis screening. (2008)
  • Author(s): Yamagata K
  • Journal Title: Clinical and experimental nephrology 12(1) Pages: 1-8
  • Peer Reviewed
• [Journal Article] The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy. (2008)
  • Author(s): Sato W
  • Journal Title: Laboratory investigation 88(9) Pages: 949-961
  • Peer Reviewed
• [Journal Article] Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. (2008)
  • Author(s): Aoyama T
  • Journal Title: Circulation journal 72(1) Pages: 56-60
  • Peer Reviewed
• [Journal Article] Chronic Kidney Disease Japan Cohort (CKD-JAC) study : design and methods. (2008)
  • Author(s): Imai E
  • Journal Title: Hypertension research 31(6) Pages: 1101-1107
  • Peer Reviewed
• [Journal Article] Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. (2008)
  • Author(s): Shoichi Maruyama
  • Journal Title: Kidney international 74(12) Pages: 1603-9
  • Peer Reviewed
• [Journal Article] Lipid droplet-associated proteins protect renal tubular cells from fattyacid-induced apoptosis. (2008)
  • Author(s): Urahama Y
  • Journal Title: Ameircan journal of Pathology 173(5) Pages: 1286-1294
  • Peer Reviewed
• [Journal Article] A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab. (2008)
  • Author(s): Fumiaki Sugiura
  • Journal Title: Mod Rheumatol (In press)
  • Peer Reviewed
• [Journal Article] Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-ss-galactosidase (ABase) for ABO-incompatible transplantation (2008)
  • Author(s): Kobayashi T
  • Journal Title: Transplant immunology Jan ; 20(3) Pages: 132-8
  • Peer Reviewed
• [Journal Article] Characteristics and causes of immune dysfunction related to uremia and dialysis. (2008)
  • Author(s): Hauser AB
  • Journal Title: Peritoneal Dialysis International Suppl 3
  • Peer Reviewed
• [Journal Article] Geographic difference in the prevalence of chronic kidney disease among Japanese screened subjects : Ibaraki versus Okinawa. (2008)
  • Author(s): Iseki K
  • Journal Title: Clinical and experimental nephrology (In press)
  • Peer Reviewed
• [Journal Article] Simple sampling strategy for measuring inulin renal clearance. (2008)
  • Author(s): Horio M
  • Journal Title: Clinical and experimental nephrology (In press)
  • Peer Reviewed
• [Journal Article] A Serine/Threonine liinase, Got/Tp12, Regulates Renal Cell Apoptosis in Ischemia/Reperfusion Injury (2008)
  • Author(s): Takaaki Yaomura
  • Journal Title: Nephrology 13(5) Pages: 397-404
  • Peer Reviewed
• [Journal Article] Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. (2008)
  • Author(s): Nishimura H
  • Journal Title: American journal of physiology. Renal physiology 294
  • Peer Reviewed
• [Journal Article] Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease. (2008)
  • Author(s): Ishii H
  • Journal Title: Clinical journal of the American Society of Nephrology 3(4) Pages: 1034-1040
  • Peer Reviewed
• [Journal Article] Aspects of Immune Dysfunction in End-stage Renal Disease. (2008)
  • Author(s): Kato S
  • Journal Title: Clinical journal of the American Society of Nephrology 3(5) Pages: 1526-1533
  • Peer Reviewed
• [Journal Article] Slower decline of glomerular filtration rate in the Japanese general population : a longitudinal 10-year follow-up study. (2008)
  • Author(s): Imai E
  • Journal Title: Hypertension research 31(3) Pages: 433-441
  • Peer Reviewed
• [Journal Article] Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy. (2008)
  • Author(s): Yuzawa Y
  • Journal Title: Journal of the American Society of Nephrology 19(9) Pages: 1701-1711
  • Peer Reviewed
• [Journal Article] Chronic kidney disease in Asia. (2008)
  • Author(s): Imai E
  • Journal Title: LANCET 371(9631) Pages: 2147-2148
  • Peer Reviewed
• [Journal Article] Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheralb arterial disease. (2008)
  • Author(s): Kumada Y
  • Journal Title: Nephrology dialysis transplantation 23(12) Pages: 3996-4001
  • Peer Reviewed
• [Journal Article] Prevalence of Pancreatic Cystic Lesions Including Intraductal Papillary Mucinous Neoplasms in Patients With End-Stage Renal Disease on Hemodialysis. (2008)
  • Author(s): Ishikawa T
  • Journal Title: Pancreas (In press)
  • Peer Reviewed
• [Journal Article] Aortic valvular calcification predicts re stenosis after implantation of drug-eluting stents in patients on chronic haemodialysis. (2008)
  • Author(s): Ishii H
  • Journal Title: Nephrology dialysis transplantation (In press)
  • Peer Reviewed
• [Journal Article] Novel culture system of mesenchymal stromal cells from human subcut aneous adipose tissue. (2008)
  • Author(s): Iwashima S
  • Journal Title: Stem Cells and Development (In press)
  • Peer Reviewed
• [Journal Article] Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hapten-induced contact hypersensitivity. (2008)
  • Author(s): Ishimoto T
  • Journal Title: Molecular Therapy 16(2) Pages: 387-95
  • Peer Reviewed
• [Journal Article] Efficiency of laparoscopic-assisted renal biopsy. (2008)
  • Author(s): Anas CM
  • Journal Title: Clinical Nephrology 70(3) Pages: 203-9
  • Peer Reviewed
• [Journal Article] Aspects of immune dysfunction in end-staee renal disease. (2008)
  • Author(s): Kato S
  • Journal Title: Clinical journal of the American Society of Nephrology 3(5) Pages: 1526-33
  • Peer Reviewed
• [Journal Article] Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity : value of highly expressed hDAF for xenotransplantation (2007)
  • Author(s): Liu D, Kobayashi T, Onishi A, Furusawa T, Iwamoto M, Suzuki S,Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A
  • Journal Title: Xenotransplantation 14(1) Pages: 67-73
  • Peer Reviewed
• [Journal Article] Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure (2007)
  • Author(s): Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S
  • Journal Title: International journal of Urology 14(3) Pages: 219-225
  • Peer Reviewed
• [Journal Article] Croker B Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy (2007)
  • Author(s): Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Johnson RJ
  • Journal Title: Journal of the American Society of Nephrology 18(2) Pages: 539-550
  • Peer Reviewed
• [Journal Article] Nucleolin modulates the subcellular localization of GDNF inducible zinc finger protein 1 and its roles in transcription and cell proliferation (2007)
  • Author(s): Dambara A, Morinaga T, Fukuda N, Yamakawa Y, Kato T, Enomoto A, Asai N, Murakumo Y, Matsuo S, Takahashi M
  • Journal Title: Experimental cell research 13(17) Pages: 3755-3766
  • Peer Reviewed
• [Journal Article] Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy (2007)
  • Author(s): Kosugi T, Yuzawa Y, Sato W, Arata-Kawai H, Suzuki N, Kato N, Matsuo S, Kadomatsu K
  • Journal Title: Laboratory investigation 87(9) Pages: 903-913
  • Peer Reviewed
• [Journal Article] Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy (2007)
  • Author(s): Kosugi T, Yuzawa Y, Sato W, Arata-Kawai H, Suzuki N, Kato N, Matsuo S, Kadomatsu K
  • Journal Title: equation for Japan. American journal of kidney diseases 50(6) Pages: 927-937
  • Peer Reviewed
• [Journal Article] Effects of olprinone, a phospodiesterase III inhibitor, on ischemic acuterenal failure. (2007)
  • Author(s): Anas C
  • Journal Title: International journal of Urology 14(3) Pages: 219-225
  • Peer Reviewed
• [Presentation] Characteristics and causes of immune dysfunction related to uremia and dialysis (2009)
  • Author(s): Yukio Yuzawa
  • Organizer: 3rd CKD Forum in Nagoya
  • Place of Presentation: Nagoya
  • Year and Date: 2009-02-15
• [Presentation] Characte ristics and causes of immune dysfunction related to uremia and dialysis. (2009)
  • Author(s): Yukio Yuzawa
  • Organizer: 3rd CKD Forum in Nagoya
  • Place of Presentation: Nagoya
  • Year and Date: 2009-02-15
• [Presentation] Circulating CD34-positive cells and the prognosis in chronic hemodialysis patients (2008)
  • Author(s): Takenori Ozaki, Shoichi Maruyama, Akihiko Taguchi, Shigejiro Iwashima, Kaoru Yasuda, Hideki Ishii, Hiroshi Takahashi, Hirotake Kasuga, Michie Ito, Keiko Kimura, Takanobu Toriyama, Yasuhiko Ito, Yukio Yuzawa, Hirohisa Kawahara, and Seiichi Matuso
  • Organizer: The 2nd Research Forum on Chronic Kidney Disease
  • Place of Presentation: 名古屋
  • Year and Date: 2008-02-02
• [Presentation] Elevated Serum Resistin Level Is Associated with Left Ventricular Hypertrophy in Chronic Kidney Disease Patients on Hemodialysis (2008)
  • Author(s): Isao Ito, Shoichi Maruyama, Kiyonari Kato, Hiroshi Takahashi, Takanobu Toriyama, Hirohisa Kawahara, Seiichi Matsuo, Yukio Yuzawa
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Urinary Midkine Is a Sensitive Biomarker of Ischemic Acute Kidney Injury and an Early Ditection of Acute Kidney Injury in Human (2008)
  • Author(s): Hiroki Hayashi, Yukio Yuzawa, Shoichi Maruyama, Waichi Sato, Akinori Hobo, Shinya Ikematsu, Daisuke Sugiyama, Kenji Kadomatsu, Seiichi Matsuo
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Beta2 Microglobulin as an Indicator of Residual Renal Function and Adequacy for Peritoneal Dialysis (2008)
  • Author(s): Yasuhiko Ito, Masashi Mizuno, Hayato Nishimura, Yasuhiro Suzuki, Makoto Mizutani, Akiho Sawai, Hideki Hiramatsu, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Elevated Cardiac Troponin T and C-Reactive Protein Interactively Increased Cardiovascular and All-Cause Mortality Risk in Hemodialysis Patients (2008)
  • Author(s): Shigejiro Iwashima, Shoichi Maruyama, Hirotake Kasuga, Hiroshi Takahashi, Takanobu Toriyama, Hirohisa Kawahara, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞の骨粗鬆症モデルマウスでの検討 (2008)
  • Author(s): 坂洋祐・丸山彰一・岩島重二郎・渡辺達人・安田香・尾崎武徳・湯澤由紀夫・松尾清一・今泉正恭・北川泰雄
  • Organizer: 第29回日本炎症・再生医学会
  • Place of Presentation: 東京
• [Presentation] URINARY MIDKINE IS A SENSITIVE BIOMARKER OF ACUTE TUBULAR NECROSIS IN HUMAN (2008)
  • Author(s): Hiroki Hayashi, Yukio Yuzawa, Shoichi Maruyama, Akinori Hobo, Shinya Ikematsu, Daisuke Sugiyama, Kenji Kadomastu, Seichi Matsuo
  • Organizer: 45th ERA-EDTA Congress
  • Place of Presentation: Stockholm
• [Presentation] 低血清培養ヒト脂肪由来間葉系細胞はラットの下肢虚血を改善する (2008)
  • Author(s): 岩島重二郎・丸山彰一・坂洋祐・渡辺達人・安田香・尾崎武徳・湯澤由紀夫・北川泰雄・室原豊明・松尾清一
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
• [Presentation] ラット尿失禁モデルにおける低血清培養脂肪由来間葉系細胞を用いた治療実験 (2008)
  • Author(s): 渡辺達人・丸山彰一・松尾清一・山本徳則・後藤百万
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
• [Presentation] 脂肪由来間葉系細胞を用いた低血清培養法の検討 (2008)
  • Author(s): 坂洋祐・丸山彰一・岩島重二郎・渡辺達人・安田香・尾崎武徳・湯澤由紀夫・松尾清一・今泉正恭・北川泰雄
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
• [Presentation] 低血清培養法による脂肪組織由来間葉系細胞の骨粗鬆症モデルマウスでの検討 (2008)
  • Author(s): 坂洋祐・丸山彰一・岩島重二郎・渡辺達人・安田香・尾崎武徳・湯澤由紀夫・松尾清一・今泉正恭・北川泰雄
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
• [Presentation] Update of the Estimated Prevalence of CKD in Japan from Recent Annual Health Checkup Data of 574, 024 Subjects. (2008)
  • Author(s): Masaru Horio
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Connective Tissue Growth Factor (CCN2/CTGF) Is Increased in High Peritoneal Solute Transport Ratein Peritoneal Dialysis Patients. (2008)
  • Author(s): Makoto Mizutani
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Elevated Cardiac Troponin T and C-Reactive Protein Interactively Increased Cardiovascular and All-Cause Mortality Risk in Hemodialysis Patients. (2008)
  • Author(s): Shigejiro Iwashima
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Moderate Chronic Kidney Disease Is Associated with Echo-Cardiographic Abnormalities. (2008)
  • Author(s): Shigeki Yamada
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Ventricular Arrhythmias during Hemodialysis Session Are Associated with Severity of Coronary Artery Disease. (2008)
  • Author(s): Yutaka Ito
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Geographic Difference in Prevalence of Chronic Kidney Disease among Japanese Screened Subjects : Ibaraki vs. Okinawa. (2008)
  • Author(s): Kunitoshi Iseki
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Malnutrition and Inflammation Interactively Increased Cardiovascular and All-Cause Mortality Risk in End-Stage Renal Disease Patients Long-Term Follow-Up Study from Induction of Dialysis Therapy. (2008)
  • Author(s): Yasuhiko Ito
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Beta2 Microglobulin as an Indicator of Residual Renal Function and Adequacy for Peritoneal Dialysis. (2008)
  • Author(s): Yasuhiko Ito
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] The Growth Factor Midkine Is a Critical Regulator of Blood Pressure through the Renin Aneiotensin Aldosterone System. (2008)
  • Author(s): Akinori Hobo
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Urinary Midkine Is a Sensitive Biomarker of Ischemic Acute Kidney Injury and an Early Ditection of Acute Kidney Injury in Human. (2008)
  • Author(s): Hiroki Hayashi
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Long-Term Outcome of Percutaneous Transluminal Angioplasty in Chronic Hemodialysis Patients with Peripheral Arterial Disease. (2008)
  • Author(s): Hirotake Kasuga
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Elevated Serum Resistin Level Is Associated with Left Ventricular Hypertrophy in Chronic Kidney Disease Patients on Hemodialysis. (2008)
  • Author(s): Isao Ito
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] Aortic Calcification Index Is a Strong Predictor of Csirdiovascular Mortality in Chronic Hemodialysis Patients. (2008)
  • Author(s): Yuka Sobajima
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Ptiladelphia
• [Presentation] Peripheral Arterial Disease in End-Stage Renad Disease Patients with Diabetes Long-Term Follow-Up Study from Inducting Hemodialysis Therapy. (2008)
  • Author(s): Yasumitsu Mori
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Pliiladelphia
• [Presentation] Revised Equations for Estimating Glomeriilar Filtration Rate from Serum Creatinine in Japan (2008)
  • Author(s): Seiichi Matsuo
  • Organizer: 41rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia
• [Presentation] ACUTE KIDNEY INJURY (AKI) IS ONE OF THE MAJOR PROGNOSTIC FACTORS FOR THE PATIENTS WITH ACUTE LUNG INJURY/ACUTE RESPIRATORY DISTRESS SYNDROME (2008)
  • Author(s): Sachiyo Suzuki
  • Organizer: 45th ERA-EDTA Congress
  • Place of Presentation: Stockholm
• [Presentation] URINARY MIDKINE IS A SENSITIVE BIOMARKER OF ACUTE TUB ULAR NECROSIS IN HUMAN. (2008)
  • Author(s): Hiroki Hayashi
  • Organizer: 45th ERA-EDTA Congress
  • Place of Presentation: Stockholm
• [Presentation] (2007)
  • Author(s): Yukio Yuzawa
  • Organizer: Characteristics and Causes of Immune Dysfunction in Uremia 3rd Asian Chapter Meeting of International Society for Peritoneal Dialysis
  • Place of Presentation: Hiroshima
  • Year and Date: 2007-11-24
• [Presentation] Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Apoptosis Induced by Fatty Acids (2007)
  • Author(s): Yoshimichi Urahama, Shoichi Maruyama, Yukio Yuzawa, Toyoshi Fujimoto, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease (2007)
  • Author(s): Kaoru Yasuda, Shoichi Maruyama, Takenori Ozaki, Shigejiro Iwashima, Hirotake Kasuga, Takanobu Toriyama, Hirohisa Kawahara, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Adipose Derived Stromal Cells Cultured in Low-Serum Media Secrete High Levels of Cytokines and Ameliorate Acute Kidney Injury (2007)
  • Author(s): Takenori Ozaki, Shoichi Maruyama, Tatsuto Watanabe, Shigejiro Iwashima, Kaoru Yasuda, Tokunori Yamamoto, Yasuo Kitagawa, Momokazu Gotoh, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Novel Autologous Cell Therapy for Cisplatin Induced Acute Kidney Injury by Using Adipose Derived Stromal Vascular Fraction (2007)
  • Author(s): Kaoru Yasuda, Shoichi Maruyama, Takenori Ozaki, Tatsuto Watanabe, Shigejiro Iwashima, Tokunori Yamamoto, Yukio Yuzawa, Momokazu Gotoh, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] High Prevalence of Cardiac Valve Calcification and Its Association with Future Cardiovascular Morbidity and Mortality in End-Stage Renal Disease Patients at Beginning of Hemodialysis Therapy (2007)
  • Author(s): Yutaka Fujita, Tomomi Ueda, Michie Itou, Hirotake Kasuga, Takanobu Toriyama, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Cardiac Troponin T Predicts Long-Term Cardiovascular Morbidity and Mortality in Chronic Kidney Disease Patients on Maintenance Hemodialysis (2007)
  • Author(s): Shigejiro Iwashima, Shoichi Maruyama, Takenori Ozaki, Kaoru Yasuda, Hirotake Kasuga, Takanobu Toriyama, Hirohisa Kawahara, Yukio Yuzawa, Seiichi Matsuo
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Adipose Derived Stromal Cells Cultured in Low-Serum Media Secrete High Levels of Cytokines and Ameliorate Acute Kidney Injury. (2007)
  • Author(s): T Ozaki
  • Organizer: 40rd Annual Meeting of The American Society of Nephrology
  • Place of Presentation: San Francisco