• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Screening of novel biomarkers and therapeutic targets in diabetic nephropathy

Research Project

Project/Area Number 19590949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University

Principal Investigator

SUGAHARA Akira  Kyoto University, 医学研究科, 臨床教授 (00312223)

Co-Investigator(Renkei-kenkyūsha) MORI Kiyoshi  京都大学, 医学研究科, 講師 (60343232)
SATOU Noriko  京都医療センター・臨床研究センター, 研究員 (80373512)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords腎臓学 / 内科 / マイクロアレイ / 糖尿病 / 蛋白質 / 慢性腎不全 / 慢性腎臓病 / バイオマーカー / ネフロン / 探索
Research Abstract

1型および2型糖尿病のマウスモデルを用いて、糖尿病性腎症の早期に発現増加が改善する遺伝子としてgremlin 1、growth arrest-specific 6、Wt-1、Rab3bなどを同定し、これらの因子の糖尿病性腎症への関与が示唆された。さらに糖尿病性腎症においては尿中Ngal が増加し、アンギオテンシン受容体阻害薬の投与により減少することを明らかにし、尿中Ngal の新規バイオマーカーとしての有用性を報告した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007 2006 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (27 results) Remarks (1 results)

  • [Journal Article] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blocker in hypertensive patients2009

    • Author(s)
      Kasahara M, Mori K, Satoh N, Kuwabara T, Yokoi H, Shimatsu A, Sugawara A, Mukoyama M, Nakao K
    • Journal Title

      Nephrol Dial Transpl (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons2009

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Yoshioka T, Ogawa Y, Imamaki H, Kusakabe T, Ebihara K, Omata M, Satoh N, Sugawara A, Barasch J, Nakao K
    • Journal Title

      Kidney Int 75(3)

      Pages: 285-94

    • NAID

      120005678177

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of urinary excretion of neutrophil gelatinase-associated lipocalin by angiotensin receptor blocker in hypertensive patients.2009

    • Author(s)
      M. Kasahara, et al.
    • Journal Title

      Nephrol Dial Transplant (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.2009

    • Author(s)
      T. Kuwabara, et al.
    • Journal Title

      Kidney Int 75

      Pages: 285-294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury2008

    • Author(s)
      Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, Buchen C, Khan F, Mori K, Giglio J, Devarajan P, Barasch J
    • Journal Title

      Ann Intern Med 148(11)

      Pages: 810-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis2008

    • Author(s)
      Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
    • Journal Title

      Kidney Int 74(1)

      Pages: 70-80

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice2008

    • Author(s)
      Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K
    • Journal Title

      Kidney Int 73(4)

      Pages: 446-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myasthenia-like syndrome induced by cibenzoline overdose in a patient with chronic kidney disease2008

    • Author(s)
      Kawasaki H, Yahata K, Okamoto C, Imamaki H, Seta K, Sugawara A
    • Journal Title

      Nippon Jinzo Gakkai Shi 50(7)

      Pages: 942-7

    • NAID

      10024901318

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic AA amyloidosis caused by familial Mediterranean fever and response to colchicines2008

    • Author(s)
      Fukui N, Mukoyama M, Saito Y, Mori K, Kasahara M, Yokoi H, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
    • Journal Title

      Nippon Naika Gakkai Zasshi 97(12)

      Pages: 3046-8

    • NAID

      10024933107

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008

    • Author(s)
      T. Nagae, et al.
    • Journal Title

      Kidney Int 74

      Pages: 70-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2008

    • Author(s)
      H. Yokoi, et al.
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myasthenia-like syndrome induced by cibenzoline overdose in a patient with chronic kidney disease.2008

    • Author(s)
      H. Kawasaki, et al.
    • Journal Title

      Nippon Jinzo Gakkai Shi 50

      Pages: 942-947

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic AA amyloidosis caused by familial Mediterranean fever and response to colchicine.2008

    • Author(s)
      N. Fukui, et al.
    • Journal Title

      Nippon Jinzo Gakkai Shi 97

      Pages: 3046-3048

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase2008

    • Author(s)
      Nagae T, Mori K, et. al.
    • Journal Title

      Kidney Int (掲載決定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage2007

    • Author(s)
      Mori K, Nakao K
    • Journal Title

      Kidney Int 71(10)

      Pages: 967-70

    • NAID

      120004225591

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney2007

    • Author(s)
      Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K
    • Journal Title

      Am J Physiol Renal Physiol 293(4)

      Pages: 1363-72

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2007

    • Author(s)
      Yokoi H, Mukoyama M, et. al.
    • Journal Title

      Kidney Int 73

      Pages: 446-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.2007

    • Author(s)
      Sawai K, Mukoyama M, et. al.
    • Journal Title

      Am J Physiol Renal Physiol 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone2006

    • Author(s)
      Makino H, Miyamoto Y, Sawai K, Mori K,Mukoyama M, Nakao K, Yoshimasa Y, Suga S
    • Journal Title

      Diabetes 55(10)

      Pages: 2747-56

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Urinary Neutrophil Gelatinase-Associated Lipocalin (Ngal) is a Powerful Bioraarker of Disease Activity and Treatment Efficacy in Chronic Kidney Disease (CKD)2009

    • Author(s)
      T. Kuwabara, et al.
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Urinary Neutrophil Gelatinase-Associated Lipocalin(Ngal)is a Powerful Biomarker of Disease Activity and Treatment Efficacy in Chronic Kidney Disease(CKD)2009

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Sugawara A, Nakao K
    • Organizer
      日本循環器学会学術集
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Reduction of urinary excretion of neutrophil gelatinase associated lipocalin (Ngal) by angiotensin receptor2008

    • Author(s)
      T. Kuwabara, et al.
    • Organizer
      American Society of Nephrology (ASN)
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高血圧・高脂血症を伴うCKD(慢性腎臓病)患者における血圧コントロール後のスタテンによる蛋白尿減少、腎保護効果について2008

    • Author(s)
      岡本千夏, ほか
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons.2008

    • Author(s)
      K. Mori, et al.
    • Organizer
      International Society of Hypertension (ISH)
    • Place of Presentation
      Berlin
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adrenomedullin gene transfer in rat kidney inhibits connective tissue growth factor, extracellular signal-regulated kinase, and renal fibrosis.2008

    • Author(s)
      T. Nagae, et al.
    • Organizer
      The Endocrine Society (ENDO)
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 尿中Ngal濃度の解析から考えられる理想の腎障害マーカー像(Kidney Biomarkerology 2008).2008

    • Author(s)
      森潔, ほか
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ネフローゼ治療中の血中・尿中Neutrophil gelatinase associated lipocalin (Ngal)濃度の推移2008

    • Author(s)
      桑原孝成, ほか
    • Organizer
      日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Urinary Ngal is a kidney injury biomarker which integrates information of damage in glomeruli, proximal tubules and distal nephrons2008

    • Author(s)
      Mori K, Kuwabara T, Mukoyama M, Kasahara M, Yokoi H, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao
    • Organizer
      International Society of Hypertension (ISH) meeting
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] Adrenomedullin gene transfer into rat kidney ameliorates obstructive renal fibrosis through inhibition of connective tissue growth factor and extracellular signal-regulated kinase2008

    • Author(s)
      Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
    • Organizer
      International Society of Hypertension(ISH)meeting
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] Urinary Ngal as an early biomarker for diabetic nephropathy in mice2008

    • Author(s)
      Mori K, Kuwabara T, Mukoyama M, Saito Y, Kasahara M, Yokoi H, Ogawa Y, Imamaki H, Nakao K
    • Organizer
      The Shiga International Symposium on Diabetic Nephropathy meeting
    • Place of Presentation
      Otsu
    • Related Report
      2008 Final Research Report
  • [Presentation] Reduction of urinary excretion of neutrophil gelatinaseassociated lipocalin(Ngal)by angiotensin receptor blockers(ARBs)in diabetic or obese subjects2008

    • Author(s)
      Kuwabara T, Mori K, Satoh N, Kasahara M, Yokoi H, Saito Y, Imamaki H, Nagae T, Ogawa Y, Barasch J, Sugawara A, Mukoyama M, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      Philadelphia
    • Related Report
      2008 Final Research Report
  • [Presentation] 1型及び2型糖尿病に伴う糖尿病性腎症モデルマウスの糸球体における遺伝子発現変動パターンの網羅的解析2008

    • Author(s)
      森潔、〓原孝成、向山政志、斎藤陽子、笠原正登、横井秀基、吉岡徹朗、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ネフローゼ治療中の血中・尿中Neutrophil gelatinase-associated lipocalin (Ngal)濃度の推移2008

    • Author(s)
      〓原孝成, 森潔, 向山政志, 笠原正登,横井秀基, 小川喜久, 齋藤陽子, 今牧博貴, 菅原照, 中尾一和
    • Organizer
      日本内科学会講演会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 尿中Ngal 濃度の解析から考えられる理想の腎障害マーカー像(Kidney Biomarkerology 2008)2008

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖尿病性腎症モデルマウスの回復早期に発現変動する遺伝子群の同定2008

    • Author(s)
      森潔、〓原孝成、向山政志、斎藤陽子、笠原正登、横井秀基、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      青森
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 内分泌因子・液性因子と腎予後予測-NgalとBNPを中心に-2008

    • Author(s)
      向山政志、森潔、笠原正登、原田昌樹、中尾一和
    • Organizer
      日本腎臓学会西部学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 2種の糖尿病性腎症モデルマウスの糸球体において共通に発現増加する遺伝子の網羅的解析2008

    • Author(s)
      森潔、〓原孝成、向山政志、笠原正登、横井秀基、斎藤陽子、小川喜久、今牧博貴、菅原照、中尾一和
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 高血圧・高脂血症を伴うCKD(慢性腎臓病)患者における血圧コントロール後のスタチンによる蛋白尿減少、腎保護効果について2008

    • Author(s)
      岡本千夏、小泉三輝、菊地祐子、瀬田公一、八幡兼成、菅原照
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] Forest Fire Theory for Renal Failure and Clinical Impact of Neutrophil Gelatinase-Associated Lipocalin2007

    • Author(s)
      Mori K, Mukoyama M, Nickolas TL, Barasch J, Nakao K
    • Organizer
      International Society of Nephrology(ISN)meeting
    • Place of Presentation
      Brazil
    • Related Report
      2008 Final Research Report
  • [Presentation] Distinct Urinary Excretion of Albumin, Beta-2 microglobulin and Neutrophil Gelatinase-Associated Lipocalin in Mouse Models of Diabetic Nephropathy2007

    • Author(s)
      Kuwabara T, Mori K, Mukoyama M, Saito Y, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Imamaki H, Sugawara A, Barasch J, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Blood and Urinary Neutrophil Gelatinase-Associated Lipocalin (Ngal) Levels in the Treatment Courses of Proteinuric Glomerular Diseases2007

    • Author(s)
      Mori K, Kuwabara T, Mukoyama T, Kasahara M, Yokoi H, Yoshioka T, Ogawa Y, Saito Y, Imamaki H, Sugawara A, Barasch J, Nakao K
    • Organizer
      American Society of Nephrology(ASN)meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] 夜間血圧コントロールによる蛋白尿減少と腎保護効果2007

    • Author(s)
      岡本千夏、小泉三輝、菊地祐子、瀬田公一、八幡兼成、菅原照.
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎不全の「山火事」理論とNeutrophil gelatinase-associated lipocalin2007

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、吉岡徹朗、小川喜久、齊藤陽子、菅原照、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2008 Final Research Report
  • [Presentation] I型及びII型糖尿病に伴う糖尿病性腎症モデルマウスの糸球体における遺伝子発現変動パターンの網羅的解析2007

    • Author(s)
      〓原孝成、森潔、向山政志、齊藤陽子、笠原正登、横井秀基、吉岡徹朗、小川喜久、菅原照、中尾一和
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Neutrophil gelatinaseassociated lipocalinの臨床的意義及び腎不全の「山火事」理論2007

    • Author(s)
      森潔、向山政志、笠原正登、横井秀基、〓原孝成、吉岡徹朗、小川喜久、齊藤陽子、菅原照、中尾一和
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎不全におけるNgal : siderophore : Fe複合体の意義2007

    • Author(s)
      森潔、向山政志、笠原正登、中尾一和
    • Organizer
      日本透析医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/kidney.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi