Role of tonsillar lymphocyte glycogenes in the pathogenesis of IgA nephropathy

• Project/Area Number: 19590951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: SUGIYAMA Hitoshi Okayama University, 大学院・医歯薬学総合研究科, 教授 (60325090)
• Research Collaborator: INOUE Tatsuyuki 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 腎臓学 / 慢性腎臓病 / IgA腎症 / 糖鎖 / 糖転移酵素 / Glycogene / 扁桃 / CD19陽性B細胞 / β3GalT

Research Abstract

IgA腎症の成因には粘膜免疫、特に扁桃が注目され、IgA分子O型糖鎖不全が証明されている。この糖鎖不全IgAの産生機序、原因解明のためIgA腎症扁桃B細胞における糖転移酵素遺伝子(glycogene)発現を検討したところ、IgA腎症扁桃CD19陽性B細胞ではβ3GalT、pp-GalNAc-T2、Cosmc遺伝子発現低下を認めた。なかでもβ3GalT遺伝子発現は腎障害と有意な相関関係が認められ、IgA腎症の成因には扁桃B細胞における糖転移酵素遺伝子発現異常が存在することが明らかとなった。

Research Products

• [Journal Article] Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases : a report of three cases. Clin (2008)
  • Author(s): Sugiyama H, Maruyama M, Morinaga H, Inoue T, Takiue KI, Kikumoto Y, Kinomura M, Sada KE, Akagi S, Kitamura S, Maeshima Y, Makino H
  • Journal Title: Exp. Nephrol 12 Pages: 450-454
  • Peer Reviewed
• [Journal Article] A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy (2008)
  • Author(s): Kinomura M, Sugiyama H, Saito T, Matsunaga A, Sada K, Kanzaki M, Takazawa Y, Maeshima Y, Yanai H, Makino H
  • Journal Title: Nephrol Dial Transplant 23(2) Pages: 751-756
  • Peer Reviewed
• [Journal Article] Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases : a report of three cases. (2008)
  • Author(s): Sugiyama H, Maruyama M, et al.
  • Journal Title: Clin. Exp. Nephrol. 12 Pages: 450-454
  • Peer Reviewed
• [Journal Article] A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy. (2008)
  • Author(s): Kinomura M, Sugiyama H, et al.
  • Journal Title: Nephrol Dial Transplant. 23 Pages: 751-756
  • Peer Reviewed
• [Journal Article] Proposal of podocytic infolding glomerulopathy as a new disease entity : a review of 25 cases from nationwide research in Japan. (2008)
  • Author(s): Joh K, Taguchi T, Sugiyama H, et al
  • Journal Title: Clin. Exp. Nephrol. 12 Pages: 421-431
  • Peer Reviewed
• [Journal Article] Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice. (2008)
  • Author(s): Fukuoka N., Sugiyama H, et al
  • Journal Title: Am J Nephrol. 28 Pages: 661-668
  • Peer Reviewed
• [Journal Article] Downregulation of the beta1,3- galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy (2007)
  • Author(s): Inoue T., Sugiyama H., Kikumoto Y., Fukuoka N., Maeshima Y., Hattori H., Fukushima K., Nishizaki K., Hiki Y., Makino H.
  • Journal Title: Contrib Nephrol 157 Pages: 120-124
  • Peer Reviewed
• [Journal Article] Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients (2007)
  • Author(s): Maruyama M., Sugiyama H., Sada K., Kobayashi M., Maeshima Y., Yamasaki Y., Makino H.
  • Journal Title: Clin. Nephrol 68(2) Pages: 73-80
  • Peer Reviewed
• [Journal Article] Downregulation of the betal,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy (2007)
  • Author(s): Inoue T, Sugiyama H, et. al.
  • Journal Title: Contribution Nephrology 157 Pages: 120-124
  • Peer Reviewed
• [Journal Article] Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients (2007)
  • Author(s): Maruyama M, Sugiyama H, et. al.
  • Journal Title: Clinical Nephrology 68 Pages: 73-80
  • Peer Reviewed
• [Presentation] Functional cafalase deficiency exacerbates glomerulosclerosis but not albuminuria in a murine adriamycin nephrosis model (2008)
  • Author(s): Takiue K., Sugiyama H., et al
  • Organizer: ASN Renal Week 2008
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2008-11-07
• [Presentation] IgA腎症に対する扁桃摘出術・ステロイドパルス療法 : 非寛解症例の検討 (2008)
  • Author(s): 井上達之, 杉山 斉, 他
  • Organizer: 日本腎臓学会西部学術大会
  • Place of Presentation: ウィルあいち(名古屋)
  • Year and Date: 2008-09-26
• [Presentation] IgA腎症扁桃でのガラクトース転移酵素遺伝子発現低下は臨床的重症度と相関する (2008)
  • Author(s): 井上達之, 杉山 斉, 他
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-05-31
• [Presentation] IgA腎症患者の扁桃における糖転移酵素遺伝子発現の解析 (2007)
  • Author(s): 井上達之, 杉山斉, 他
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
  • Year and Date: 2007-05-27
• [Presentation] IgA腎症に対する扁桃摘出術・ステロイドパルス療法の尿所見寛解への影響を及ぼす因子の検討 (2007)
  • Author(s): 井上達之, 杉山斉, 他
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
  • Year and Date: 2007-05-27
• [Presentation] Differential expression of glycogenes in tonsillar B cells in association with proteinuria and renal function in IgA nephropathy (2007)
  • Author(s): Inoue T, Sugiyama H, et.al.
  • Organizer: The 40th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Francisco, USA