| Project/Area Number |
19590953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kansai Medical University (2008)
The University of Tokushima (2007) |
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Principal Investigator |
TSUKAGUCHI Hiroyasu Kansai Medical University, 医学部, 助教 (60335792)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Toshio 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60183498)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ポドサイト / 腎不全 / ネフローゼ症候群 / ネフローゼ / 遺伝子 / 糸球体 |
|---|
| Research Abstract |
Steroid resistance nephrotic syndrome, characterized by renal histology of focal segmental glomerulosclerosis, is a leading cause of childhood end-stage renal failure. There are a significant ethnic difference in genetic factors underlying autosomal recessive, familial SRNS. Linkage mapping with 17 Asian SRNS families demonstrated a new disease locus with a multi-point LOD score of 5.8 (α=0.7, manuscript in preparation). The candidate interval spans about 3.5Mb, which contains～50 genes. We are currently doing mutational analysis of candidate genes, particularly focusing on those which are specifically enriched in glomeruli
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