Analysis of Candidate Genes within a New Disease Locus in Asian Patients with Steroid Resistance Nephrotic Syndrome
| Project/Area Number |
19590953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kansai Medical University (2008)
The University of Tokushima (2007) |
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Principal Investigator |
TSUKAGUCHI Hiroyasu Kansai Medical University, 医学部, 助教 (60335792)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Toshio 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60183498)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ポドサイト / 腎不全 / ネフローゼ症候群 / ネフローゼ / 遺伝子 / 糸球体 |
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| Research Abstract |
Steroid resistance nephrotic syndrome, characterized by renal histology of focal segmental glomerulosclerosis, is a leading cause of childhood end-stage renal failure. There are a significant ethnic difference in genetic factors underlying autosomal recessive, familial SRNS. Linkage mapping with 17 Asian SRNS families demonstrated a new disease locus with a multi-point LOD score of 5.8 (α=0.7, manuscript in preparation). The candidate interval spans about 3.5Mb, which contains～50 genes. We are currently doing mutational analysis of candidate genes, particularly focusing on those which are specifically enriched in glomeruli
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney2010
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T.
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Journal Title
Nephrol Dial Transplant (Epub ahead of print)
Related Report
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[Journal Article] Toll-like receptor 9 affects severity of IgA nephropathy2008
Author(s)
Suzuki H, Suzuki Y, Narita I, Aizawa M, Kihara M, Yamanaka T, Kanou T, Tsukaguchi H, Novak J, Horikoshi S, Tomino Y.
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Journal Title
J Am Soc Nephrol 19(12)
Pages: 2384-2395
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[Journal Article] Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation2008
Author(s)
Furue T, Hattori M, Tsukaguchi H, Kitamura A, Oomori T, Ogino D, Nakakura H, Ashida A, Miura K, Hisano M, Takahashi K, Chikamoto H, Akioka Y, Sakano T.
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Journal Title
Pediatr Transplant 12(3)
Pages: 341-346
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