Analysis of the action and the mechanism of vasopressin via V1aR in the kidney, and the search for the new antidiuretic peptide

• Project/Area Number: 19590957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: NAKAYAMA Yushi Kumamoto University, 大学院・医学薬学研究部, 助教 (00363531)
• Co-Investigator(Kenkyū-buntansha): TOMITA Kimio 熊本大学, 大学院・医学薬学研究部, 教授 (40114772)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: バゾプレッシン / バゾプレッシンV2 受容体 / バゾプレッシンV1a 受容体 / プロモーター活性 / SP-1 モチーフ / アシドーシス / バゾプレッシンV2受容体 / バゾプレッシンV1a受容体 / SP-1モチーフ

Research Abstract

抗利尿ホルモン(AVP)の、腎臓におけるバソプレッシンV1a受容体(V1aR)-V2受容体(V2R)を介した体液量の調節メカニズムを明らかとし、またV1aR欠損マウスを用いて、V1aRがRAS系及びV2R-AQP2系をも活性化していることを示した。またV1aR欠損マウスではIV型腎尿細管性アシドーシスを生じている可能性を示した。

Research Products

• [Journal Article] Regulation of V2R transcription by hypertonicity and V1aR - V2R signal interaction (2008)
  • Author(s): Izumi, Y., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Am J Physiol Renal Physiol 295 Pages: 1170-1176
  • Peer Reviewed
• [Journal Article] Long-term observation of renal function on combination therapy with prostaglandin and angiotensin-converting enzyme inhibitor for chronic kidney disease (2008)
  • Author(s): Nakayama, Y., Tomita, K., Nonoguchi, H. et.al.
  • Journal Title: Clin Nephrol 69 Pages: 402-407
  • Peer Reviewed
• [Journal Article] Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells (2008)
  • Author(s): Aoyagi, T., Izumi, Y., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Am J Physiol Renal Physiol 295
  • Peer Reviewed
• [Journal Article] Long-term plasma levels and dose modulation of alacepril in patients with chronic renal failure (2008)
  • Author(s): Nonoguchi, H., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Hypertens Res. 31 Pages: 29-36
  • NAID: 10021260933
  • Peer Reviewed
• [Journal Article] The MAXIMA trial (2008)
  • Author(s): Nonoguchi, H., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Lancet 371 Pages: 299-300
  • Peer Reviewed
• [Journal Article] Different mechanisms for the progression of CKD with ACE gene polymorphisms (2008)
  • Author(s): Nakayama, Y., Nonoguchi, H., Tomita, K. et.al.
  • Journal Title: Nephron 111
  • Peer Reviewed
• [Journal Article] Long-term observation of renal function on combination therapy with prostaglandin and angiotensin-converting enzyme inhibitor for chronic kidney disease. (2008)
  • Author(s): Nakayama Y., 他
  • Journal Title: Clin Nephrol 69(6) Pages: 402-407
  • Peer Reviewed
• [Journal Article] Long-term plasma levels and dose modulation of alacepril in patients with chronic renal failure. (2008)
  • Author(s): Nonoguchi H., 他
  • Journal Title: Hypertens Res 31(1) Pages: 29-36
  • Peer Reviewed
• [Journal Article] Regulation of V2R transcription by hypertonicity and V1aR-V2R signal interaction. (2008)
  • Author(s): Izumi Y., 他
  • Journal Title: Am J Physiol Renal Physiol 295(4)
  • Peer Reviewed
• [Journal Article] The MAXIMA trial. (2008)
  • Author(s): Nonoguchi H., 他
  • Journal Title: Lancet 371(9609) Pages: 299-300
  • Peer Reviewed
• [Journal Article] Vasopressin regulates the renin-angiotensin-aldosterone systemvia V1a receptors in macula densa cells. (2008)
  • Author(s): Aoyagi T., 他
  • Journal Title: Am J Physiol Renal Physiol 295(1)
  • Peer Reviewed
• [Journal Article] A novel method for dry weight assessment in hemodialysis patients: utilization of inferior vena cava flat ratio to correct for individual variations in vessel diameter (2008)
  • Author(s): Naruse M., 他
  • Journal Title: Ther Apher Dial. 他 11(1) Pages: 42-48
  • Peer Reviewed
• [Journal Article] Low-responders to angiotensin II receptor blockers and genetic polymorphism in angiotensin-converting enzyme (2007)
  • Author(s): Nonoguchi, H., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Clin Nephrol 68 Pages: 209-215
  • Peer Reviewed
• [Journal Article] Target haemoglobin concentrations in chronic kidney disease (2007)
  • Author(s): Nonoguchi, H., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Lancet 369 Pages: 1517-1517
  • Peer Reviewed
• [Journal Article] A novel method for dry weight assessment in hemodialysis patients : utilization of inferior vena cava flat ratio to correct for individual variations in vessel diameter (2007)
  • Author(s): Naruse, M., Nakayama, Y., Tomita, K. et.al.
  • Journal Title: Ther Apher Dial 11 Pages: 42-48
  • Peer Reviewed
• [Journal Article] Downregulation of vasopressin V2 receptor promoter activity via V1a receptor pathway (2007)
  • Author(s): Izumi, Y., Nakayama, Y., Tomita K. et.al.
  • Journal Title: Am J Physiol Renal Physiol 292
  • Peer Reviewed
• [Journal Article] Downregulation of the V2 vasopressin recepor in dehydration: mechanisms and role of renal prostaglandin synthesis (2007)
  • Author(s): Machida K, 他
  • Journal Title: Am J Physiol Renal Physiol 292(4)
  • Peer Reviewed
• [Journal Article] Downregulation of vasopressin V2 recgptor promoter activity via V1a receptor pathway. (2007)
  • Author(s): Izumi Y., 他
  • Journal Title: Am J Physiol Renal Physiol 292(5)
  • Peer Reviewed
• [Journal Article] Target haemoglobin concentrations in chronic kidney disease. (2007)
  • Author(s): Nonoguchi H., 他
  • Journal Title: Lancet 369(9572) Pages: 1517-1517
  • Peer Reviewed
• [Journal Article] Low-responders to angiotensin II receptor blockers and genetic polymorphism in angiotehsin-converting enzymle. (2007)
  • Author(s): Nonoguchi H., 他
  • Journal Title: Clin Nephrol 68(4) Pages: 209-215
  • Peer Reviewed
• [Presentation] Renoprotection by Inhibition of GSK3 in Streptozotocin-Induced Diabetic Nephropathy; the New Approach for Reduction of Proteinuria through TGF-1 Pathway (2008)
  • Author(s): Nakayama, Y., Tomita, K. et.al.
  • Organizer: 米国腎臓学会
  • Place of Presentation: フィラデルフィア、U.S.A
  • Year and Date: 2008-11-08
• [Presentation] Renoprotection by Inhibition of GSK3 in Streptozotocin-Induced Diabetic Nephropathy ; the New Approach for Reduction of Proteinuria through TGF-1 Pathway (2008)
  • Author(s): Nakayama Y., 他
  • Organizer: アメリカ腎臓学会
  • Place of Presentation: 米国、ペンシルベニア州、フィラデルフィア
  • Year and Date: 2008-11-08
• [Presentation] The Different Mechanism of the Progression of CKD in II/DI and DD Patients with ACE Gene Polymorphism (2007)
  • Author(s): Nakayama, Y., Tomita, K. et.al.
  • Organizer: 米国腎臓学会
  • Place of Presentation: サンフランシスコ、U.S.A
  • Year and Date: 2007-11-03
• [Presentation] The Diffrent Mechanism of the Progression of CKD in II/DI and DD Patients with ACE Gene Polymorphism. (2007)
  • Author(s): Nakayama Y.
  • Organizer: アメリカ腎臓学会
  • Place of Presentation: 米国(サンフランシスコ)
  • Year and Date: 2007-11-03
• [Book] EBM腎臓病の治療 (2008)
  • Author(s): 共著 : 中山裕史
  • Publisher: 中外医学社