• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of Okinawan vegetables on blood pressure, pulse wave, renal function and oxidative stress : a prospective randomized study

Research Project

Project/Area Number 19590959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of the Ryukyus

Principal Investigator

OHYA Yusuke  University of the Ryukyus, 医学部, 教授 (30240964)

Co-Investigator(Kenkyū-buntansha) TODORIKI Hidemi  国立大学法人琉球大学, 医学部, 准教授 (60175479)
ISEKI Kunitoshi  国立大学法人琉球大学, 医学部附属病院, 准教授 (90193383)
D・CRAIG Willcox  沖縄県立看護大学, 看護学部, 講師 (70316214)
Co-Investigator(Renkei-kenkyūsha) WILLCOX Craig  沖縄国際大学, 総合文化学部, 准教授 (70316214)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords食事 / 血圧 / 野菜 / 食塩 / 脈波 / 介入 / 酸化ストレス / アルブミン尿 / 微量アルブミン / 尿中微量アルブミン
Research Abstract

To test the hypothesis that food enriched with Okinawan vegetable would improve health indexes, we investigated effects of Okinawan vegetable-rich diet on those indexes in Americans who live in Okinawa and Japanese who live in Tokyo area with a prospective randomized-controlled study. Okinawan vegetable-rich diet caused a significant reduction of blood pressure and body weight with a reduction of urinary salt excretion by about 3g. Okinawan vegetable-rich diet decreased body weight and blood pressure. In addition it improved urinary albumin excretion and circulating endothelial progenitor cells, a marker of vascular function. Diet intervention of vegetable rich diet may be a new strategy for improving life style modification.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (32 results)

All 2010 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (18 results)

  • [Journal Article] Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women.2009

    • Author(s)
      Mano R、Ishida A、Ohya Y、Todoriki H、Takishita S
    • Journal Title

      Atherosclerosis 204

      Pages: 544-548

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of heart rate on the risk of developing metabolic syndrome2009

    • Author(s)
      Inoue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S
    • Journal Title

      Hypertens Res 32

      Pages: 801-806

    • NAID

      10026123294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women2009

    • Author(s)
      Mano R, et al.
    • Journal Title

      Atheroslerosis 204

      Pages: 544-548

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of heart rate on the risk of developing metabolic syndrome2009

    • Author(s)
      Inoue T, et al.
    • Journal Title

      Hypertens Res 32

      Pages: 801-806

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart rate as a risk factor for developing chronic kidney disease : longitudinal analysis of a screened cohort2009

    • Author(s)
      Inoue t, et al.
    • Journal Title

      Clin Exp Nephrol.Oct ; 13(5)487-93 13

      Pages: 487-493

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between heart rate and multiple risk factor syndrome: cross-sectional analysis of a screened cohort in Okinawa, Japan.2008

    • Author(s)
      noue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S
    • Journal Title

      Circ J 72

      Pages: 454-457

    • NAID

      110006646502

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between heart rate and multiple risk factor syndrome: cross-sectional analysis of a screened cohort in Okinawa, Japan.2008

    • Author(s)
      Inoue T, Iseki K, Iseki C, Ohya Y, Kinjo K, Takishita S
    • Journal Title

      Circ J 72

      Pages: 454-7

    • NAID

      110006646502

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] rHuEPO dose inversely correlated with the number of circulating CD34+ cells in maintenance hemodialysis patients2008

    • Author(s)
      Kohagura K, Ohya Y, Miyagi S, Ishida A, Yakabi S, Iseki K, Yamane N, Takishita S.
    • Journal Title

      Nephron Clin Pract 108

      Pages: 41-46

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 伝統的沖縄型食事介入による地域における健康改善は可能か?-チャンプルースタディの結果から-2008

    • Author(s)
      等々力英美
    • Journal Title

      九州農誌 17

      Pages: 2-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between heart rate and multiple risk factor syndorme.2008

    • Author(s)
      Inoue T, Iseki K, Iseki C, Ohva Y, Kinjo K, Takishita S
    • Journal Title

      Circ J 72

      Pages: 454-457

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher heart rate predicts the risk of developing hypertension in a normotensive screened cohort.2007

    • Author(s)
      noue T, Iseki K, Iseki C, Kinjo K, Ohya Y, Takishita S
    • Journal Title

      Circ J 71

      Pages: 1755-1760

    • NAID

      110006448586

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caloric Restriction, energy balance and healthy aging in Okinawans and Americans: Biomarker differences in septuagenarinas.2007

    • Author(s)
      Willcox BJ、Willcox DC、Todoriki H
    • Journal Title

      The Okinawan J. American Studies 4

      Pages: 62-74

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Todoriki H、Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging The Diet of the World's Longest-Lived People and Its Potential Impact on Morbidity and Life Span2007

    • Author(s)
      Willcox BJ、Willcox DC
    • Journal Title

      Ann. N.Y. Acad. Sci. 1114

      Pages: 434-455

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intervention with Okinawan vegitables increased circulating endothelial progenitor cells in healthy young women.

    • Author(s)
      Mano R, Ishida A, Ohya Y, Todoriki H, Takishita S.
    • Journal Title

      Atherosclerosis (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dietary Intervention with Traditional Vegetable-rich Okinawa Diet Increased Circulating Endothelial Progenitor Cells in Women2010

    • Author(s)
      石田明夫, 大屋祐輔, ほか
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dietary Intervention with Traditional Vegetable-rich Okinawa Diet Increased Circulating Endothelial Progenitor Cells in Women2010

    • Author(s)
      石田明夫、大屋祐輔、真野理恵子、等々力英美、瀧下修一
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      京都府
    • Related Report
      2009 Final Research Report
  • [Presentation] 沖縄野菜を多く含む食事介入は沖縄県在住の健康米国人において微量アルブミン尿を減少させる-チャンプルースタディー3の検討より-2009

    • Author(s)
      仲本みのり, 大屋祐輔, ほか
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津プリンスホテル(滋賀県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 伝統的沖縄食事パターンは日本人においても米国人と同様な血圧降下を示す:無作為割り付けによる食事介入研究(チャンプルースタディー4)2009

    • Author(s)
      等々力秀美, 大屋祐輔, ほか
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津プリンスホテル(滋賀県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ほか伝統的沖縄食事パターンは日本人においても米国人と同様な血圧降下を示す:無作為割り付けによる食事介入研究(チャンプルースタディー4)2009

    • Author(s)
      等々力英美、大屋祐輔
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      滋賀県
    • Related Report
      2009 Final Research Report
  • [Presentation] 沖縄野菜を多く含む食事介入は沖縄県在住の健康米国人において微量アルブミン尿を減少させる-チャンプルースタディー3の検討より-2009

    • Author(s)
      仲本みのり、大屋祐輔、等々力英美、東上里康司、ほか
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      滋賀県
    • Related Report
      2009 Final Research Report
  • [Presentation] DASH食類似の伝統的沖縄食の摂取は血圧を低下させる2008

    • Author(s)
      等々力英美, 大屋祐輔, 勝亦百合子, 東上里康司, Willcox Craig, 佐々木敏
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      ロイトン札幌、札幌
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] A clinical trial of the effects of the traditional Okinawa diet on bloodpressure and other health indicators : Can DASH-like results be achieved?2008

    • Author(s)
      H. Todoriki, Y. Katsumata, Y. Ohya. D. C. Willcox, K. Zheng, S. Sasaki.
    • Organizer
      22nd Scientific Meeting, International Society of Hypertension
    • Place of Presentation
      International Congress Center, Berline, Germany
    • Year and Date
      2008-06-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] DASH食類似の伝統的沖縄食の摂取は血圧を低下させる:無作為割付による食事介入研究(チャンプルースタディ)2008

    • Author(s)
      等々力英美、大屋祐輔、勝亦百合子、東上里康司、クレイグ・ウィルコックス、佐々木敏
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      北海道
    • Related Report
      2009 Final Research Report
  • [Presentation] Dietary intervention with Okinawan vegetables through home-parcel delivery increased circulating endothelial progenitorcells in healthy young women2008

    • Author(s)
      Mano R、Ishida A、Ohya Y、Todoriki H、Takishita S
    • Organizer
      22nd Scientific Meeting International Society of Hypertension
    • Place of Presentation
      Internationales Congress Centrum Berlin (ICC), Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] A Clinical Trial of the Effects of the Traditional Okinawa Diet on Blood Pressure and other Health Indicators: Can DASH-like Results be Achieved?2008

    • Author(s)
      Todoriki H、Katsumata Y、Ohya Y、Willcox DC、Zheng KC、Sasaki S
    • Organizer
      22nd Scientific Meeting International Society of Hypertension
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] 各種だし素材使用量と野菜摂取量および摂取電解質(Na,K)量との相関:40-60歳代の沖縄県住民を対象とした栄養疫学研究2007

    • Author(s)
      黒田素央、等々力英美、大屋祐輔、佐々木敏
    • Organizer
      第30回日本高血圧学会総会
    • Place of Presentation
      沖縄
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 沖縄野菜摂取の血管内皮前駆細胞(EPC)に及ぼす影響(無作為割付研究)2007

    • Author(s)
      真野理恵子、石田明夫、大屋祐輔、等々力英美、瀧下修一
    • Organizer
      第30回日本高血圧学会総会
    • Place of Presentation
      沖縄
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Correlation between the consumption of materials for soup stock (dashi) and vegetables with respect to intake of electrolytes: Nutritional & epidemiological study ofthe Okinawan residents aged 40-69 years.2007

    • Author(s)
      Kuroda M、Todoriki H、Ohya Y、Sasaki S
    • Organizer
      The 6th Asian-Pacific Congress of Hypertension
    • Place of Presentation
      Beijing, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Radial Augmentation IndexとPulse Wave Velocityとの相関は弱い2007

    • Author(s)
      太田千亜紀、金城民子、根路銘国政、東上里康司、等々力英美、大屋祐輔
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      沖縄県
    • Related Report
      2009 Final Research Report
  • [Presentation] 沖縄野菜摂取の血管内皮前駆細胞(EPC)に及ぼす影響(無作為割付研究)2007

    • Author(s)
      真野理恵子、石田明夫、大屋祐輔、等々力英美、瀧下修一
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      沖縄県
    • Related Report
      2009 Final Research Report
  • [Presentation] 各種だし素材使用量と野菜摂取量および摂取電解質(Na、K)量との相関40-60歳代の沖縄県住民を対象とした栄養疫学研究2007

    • Author(s)
      黒田素央、等々力英美、大屋祐輔、佐々木敏
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      沖縄県
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事介入と高血圧予防-沖縄型食事と沖縄野菜の組み合わせによる食事介入研究(チャンプルースタディ)2007

    • Author(s)
      等々力英美
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      沖縄県
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi