Development of hybrid kidney for removal of protein-bound anionic uremic toxins
| Project/Area Number |
19590961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TSURUOKA Shuichi University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50285798)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Akio 自治医科大学, 医学部, 教授 (90156901)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性腎不全 / バイオ人工臓器 / 尿毒症性物質 / 有機アニオン輸送体 |
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| Research Abstract |
We developed hybrid kidney with renal cell over-expressed human organic anion transporters. We found that this system can selectively remove protein-bound uremic toxins, such as indoxyl sulfate, in animal model of chronic renal failure. We also found that some protein-bound uremic toxins directly stimulate proliferation of vascular smooth muscle cells in vitro.
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Report
(6 results)
Research Products
(37 results)
