Anti-aging therapy against chronic kidney disease
| Project/Area Number |
19590963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
HAYASHI Koichi Keio University, 医学部, 准教授 (80164937)
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| Co-Investigator(Kenkyū-buntansha) |
WAKINO Shu 慶應義塾大学, 医学部, 講師 (50265823)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 慢性腎臓病 / 加齢 / 尿細管 / Sirt1 / エネルギー代謝 / SIRT / カロリー制限 / 腎尿細管細胞 / アポトーシス / FOXO / 腎委縮 |
|---|
| Research Abstract |
加齢とともに腎組織内マクロファージの浸潤が増加傾向を示し、腎線維化も加齢により増加傾向を示した。一方、寿命と関連するSirt1はカロリー制限により腎臓での発現が亢進し、酸化ストレスなどの刺激に対し、カタラーゼ発現を亢進させることにより腎保護的に作用する。さらに近位尿細管Sirt1特異的過剰発現マウスではシスプラチンによる腎障害の改善、アポトーシス抑制が見られ、腎臓病におけるSirt1の保護作用が示唆された。
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Sirt1 protects againstoxidative stress-induced renal tubularapoptosis by bidirectional regulation of catalase expression2008
Author(s)
Hasegawa K, Wakino S, Tatematsu S, Yoshioka K, Hara Y, Minakuchi H, Tokuyama H, Washida N, Homma K,Hayashi K, Itoh H
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Journal Title
Biochemical & Biophysical Research Communications 372(1)
Pages: 51-56
Related Report
Peer Reviewed
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[Journal Article] Renal cytochrome P450 as a determinant of impaired natriuresis by PPARγ ligands in ovariectomized obese rats2008
Author(s)
Yoshioka K, Wakino S, Homma K, Kanda T,Tatematsu S, Hasegawa K, Sugano N, Ito O, Omata K, Saruta T, Hayashi K
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Journal Title
Obesity 16(5)
Pages: 965-971
Related Report
Peer Reviewed
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[Journal Article] T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy2008
Author(s)
Sugano N, Wakino S, Kanda T, Tatematsu S, Homma K, Yoshioka K, Hasegawa K, HaraY, Suetsugu Y, Yoshizawa T, Hara Y, Utsunomiya Y, Tokudome G, Hosoya T, Saruta T, Hayashi K
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Journal Title
Kidney International 73(7)
Pages: 826-834
Related Report
Peer Reviewed
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