| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In the basis of our prior studies, we hypothesized that BMP and VEGF from the glomerular podocytes have antagonistic roles for the development of glomerular capillary tufts. To assess the hypothesis, we generated inducible podocyte-specific BMP4 and VEGF transgenic mice (Tg), and analyzed phenotypes in double Tg. When compared to the single Tg, double Tg displayed more prominent phenotypes seen in the glomerulus and tubule. In conjunction with ex vivo study using mouse embryonic aortic ring, therefore, the result suggests that BMPand VEGF have collaborative effects on the tuft development, and BMP can stabilize newly formed capillary tufts by VEGF.
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