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Molecular analyses in progressive renal diseases

Research Project

Project/Area Number 19590967
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKanazawa Medical University

Principal Investigator

YOKOYAMA Hitoshi  Kanazawa Medical University, 医学部, 教授 (50191531)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎臓病 / 腎移植 / 疾患コホート / サイトカイン / ケモカイン / 組織適合抗原 / 機能分子 / 腎臟病 / 移植腎 / 細胞間接着因子
Research Abstract

We constructed prospectively the renal disease cohort including nephrotic syndrome (18 cases), lupus nephritis (33 cases), pauci-immune type rapidly progressive glomerulonephritis (RPGN, 25 cases) and renal transplanted subjects (154 cases) since 2007. We found the correlation between the genetic background (HLA-DRB1*090102) and the onset of pauci-immune type RPGN. We also revealed that the affects of lipids and total and high-molecular weight adiponectins, the non-classical HLA-G and the role of fibrocytes and pericytes in chronic allograft injury.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (68 results)

All 2010 2009 2008 2007 2006

All Journal Article (29 results) (of which Peer Reviewed: 12 results) Presentation (31 results) Book (8 results)

  • [Journal Article] Revised equations for estimated GFR from serum creatinine in Japan.2009

    • Author(s)
      S. Matsuo, E. Imai, M. Horio, Y. Yasuda, K. Tomita, K. Nitta, K. Yamagata, Y. Tomino, H. Yokoyama, A. Hishida
    • Journal Title

      Am. J. Kidney Dis.

      Pages: 53982-992

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revised equations for estimated GFR from serum creatinine in Japan.2009

    • Author(s)
      S.Matsuo
    • Journal Title

      Am.J.Kidney Dis. 53

      Pages: 982-992

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ネフローゼ症候群:診断と治療の進歩IV最近の話題 1.最新の薬物治療2009

    • Author(s)
      横山仁
    • Journal Title

      日内会誌 98

      Pages: 1062-1068

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ケースから診るCKD診療法vol.4,多量の蛋白尿が認められた症例の診断と治療2009

    • Author(s)
      横山仁
    • Journal Title

      日本医事新報 4435

      Pages: 40-44

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 当院における過去30年間のループス糸球体腎炎の臨床病理学的検討2009

    • Author(s)
      奥山 宏
    • Journal Title

      日腎会誌 51

      Pages: 44-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatibility and permeability of dialyzer membranes do not affect anemia, erythropoietin dosage or mortality in Japanese patients on chronic non-reuse hemodialysis:a prospective cohort study from the J-DOPPS II study.2008

    • Author(s)
      H. Yokoyama, et al
    • Journal Title

      Nephron Clin. Pract. 109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia-reperfusion injury as the leading cause of primary non-function in renal transplantation using donors with prolonged warm ischemic time.2008

    • Author(s)
      M. Asaka, H. Yokoyama, et al
    • Journal Title

      Clin Transplant 22(Suppl19)

      Pages: 19-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatibility and permeability of dialyzer membranes do not affect anemia, erythropoietin dosage or mortality in Japanese patients on chronic non-reuse hemodialysis : a prospective cohort study from the J-DOPPS II study2008

    • Author(s)
      H. Yokoyama
    • Journal Title

      Nephron Clin. Pract. 109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia-reperfusion injury as the leading cause of primary non-function in renal transplantation using donors with prolonged warm ischemic time2008

    • Author(s)
      M. Asaka
    • Journal Title

      Clin. Transplant. 22(Suppl19)

      Pages: 19-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ネフローゼ症候群2008

    • Author(s)
      横山 仁
    • Journal Title

      総合臨床 57

      Pages: 1253-1256

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 腎疾患 : 診断と治療の進歩 I. 診断へのアプローチ 5. 腎臓専門医への紹介のタイミング2008

    • Author(s)
      横山 仁
    • Journal Title

      口内会誌 97

      Pages: 34-39

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特集ネフローゼ症候群 : 最新の知見 膜性腎症2008

    • Author(s)
      横山 仁
    • Journal Title

      腎と透析 64

      Pages: 931-934

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特集 : CKD 検尿の評価と意義2008

    • Author(s)
      横山 仁
    • Journal Title

      日本臨休 66

      Pages: 1713-1718

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 慢性腎臓病 : CKD最新の診療 ネフローゼ症候群2008

    • Author(s)
      横山 仁
    • Journal Title

      Modern Physician 28

      Pages: 1200-1204

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 慢性腎臓病患者への薬剤治療に関する注意点2008

    • Author(s)
      横山 仁
    • Journal Title

      日薬師会誌 60

      Pages: 371-375

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A case report of an adult with severe hyperlipidemia during acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis2008

    • Author(s)
      M. Nakagawa
    • Journal Title

      Ther Apher Dial 12

      Pages: 509-513

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advances in apheresis therapy for glomerular diseases2007

    • Author(s)
      H. Yokoyama
    • Journal Title

      Clin Exp Nephrol 11

      Pages: 122-127

    • NAID

      10024140463

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of IP-10/CXCR3 promotes progressive renal fibrosis,2007

    • Author(s)
      I. Nakaya
    • Journal Title

      Nephron Exp Nephrol 107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of low-density lipoprotein apheresis(LDL-A)on refractory nephrotic syndrome(NS)due to focal glomerulosclerosis(FGS)2007

    • Author(s)
      E Muso
    • Journal Title

      Clinical Nephrology 67

      Pages: 341-344

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ネフローゼ症候群2007

    • Author(s)
      横山 仁
    • Journal Title

      総合臨床 56

      Pages: 1337-1343

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 慢性腎臓病:診断と治療の進歩 III.慢性腎臓病と検尿2007

    • Author(s)
      横山 仁
    • Journal Title

      日内会誌 96

      Pages: 15-20

    • Related Report
      2007 Annual Research Report
  • [Journal Article] C型肝炎ウイルス(HCV)関連腎炎2007

    • Author(s)
      横山 仁
    • Journal Title

      Nephrol. Fronti 6

      Pages: 158-162

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 呼吸器疾患と腎臓2007

    • Author(s)
      浅香充宏
    • Journal Title

      総合臨床 56

      Pages: 2118-2122

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 腎障害を引き起こす薬剤と副作用発見のポイント2007

    • Author(s)
      横山 仁
    • Journal Title

      クリニカルプラクティス 26

      Pages: 606-610

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 慢性腎臓病-新しい展開 慢性腎臓病治療法の背後にある考え方 蛋白尿減少を目指す理由2007

    • Author(s)
      横山 仁
    • Journal Title

      カレントテラピー 25

      Pages: 22-25

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 特集:腎疾患の血管病変 膠原病の腎血管障害-SLE, APS, PSS を中心に-2007

    • Author(s)
      横山 仁
    • Journal Title

      腎と透析 63

      Pages: 35-39

    • Related Report
      2007 Annual Research Report
  • [Journal Article] CKDにおける薬剤使用の注意点2007

    • Author(s)
      横山 仁
    • Journal Title

      日本医事新報 第4362号

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 腎臓病の治療 食事療法(3)ネフローゼ症候群2007

    • Author(s)
      山谷秀喜
    • Journal Title

      からだの科学 255

      Pages: 128-132

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Proteomic Analysis of Serum, Outflow Dialysate and Adsorbed Protein onto Dialysis Membranes (Polysulfone and PMMA) during Hemodialysis Treatment Using SELDI-TOF-MS.2006

    • Author(s)
      Ishikawa I, Chikazawa Y, Saton K, Nakagawa M, Imamura H, Hayama S, Yamaya H, Asaka M, Tomosugi N, Yokoyama H, Matsumoto K
    • Journal Title

      Am J Nephrol 26

      Pages: 372-380

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Intact parathyroid hormone levels at 3 hours of loading test reflect the effects of Cinacalcet in both hemodialysis and renal transplanted patients.2009

    • Author(s)
      H.Yokoyama
    • Organizer
      Renal Week 2009 ASN's 42nd Annual Meeting & Scientific Exposition
    • Place of Presentation
      San Diego国際会議場(San Diego市,米国)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ネフローゼ症候群:内科からのアプローチ2009

    • Author(s)
      横山仁
    • Organizer
      第39回日本腎臓学会西部学術大会ワークショップ
    • Place of Presentation
      和歌山県民文化会館(和歌山市)
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] CKDへの取り組み:臨床医の立場から-CKDにおける地域連携の進め方-2009

    • Author(s)
      横山仁
    • Organizer
      第39回日本腎臓学会西部学術大会シンポジウム
    • Place of Presentation
      和歌山県民文化会館(和歌山市)
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ループス腎炎:ISN/RPS2003分類ならびに治療に関する最近の知見2009

    • Author(s)
      横山仁
    • Organizer
      第31回腎臓セミナー
    • Place of Presentation
      海運クラブ(東京都)
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎臓病総合レジストリーシステムについて2009

    • Author(s)
      横山仁
    • Organizer
      第52回日本腎臓学会学術総会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎臓病総合レジストリー構築とシステムを利用した臨床研究紹介2009

    • Author(s)
      横山仁
    • Organizer
      第52回日本腎臓学会学術総会ワークショップ
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Statins preserved the function of transplanted kidneys under controlled blood pressure.2008

    • Author(s)
      H. Yokoyama
    • Organizer
      Renal Week 2008 ASN's 41st Annual Meeting&Scientific Exposition.
    • Place of Presentation
      Philadelphia
    • Year and Date
      2008-11-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Chronic allograft injury (CAI) as the aspect of chronic kidney disease (CKD).2008

    • Author(s)
      H. Yokoyama
    • Organizer
      The 38th Annual Congress of the Korean Society for Transplantation&The 7th Korea-Japan Transplantation Forum.
    • Place of Presentation
      Soul
    • Year and Date
      2008-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Chronic allograft injury (CAD)as the aspect of chronic kidney disease (CKD)2008

    • Author(s)
      H. Yokoyama
    • Organizer
      The 38^<th> Annual Congress of the Korean Society for Transplantation & The 7^<th> Korea-Japan Transplantation Forum
    • Place of Presentation
      ソウル
    • Related Report
      2008 Annual Research Report
  • [Presentation] statins preserved the function of transplanted kidneys under control led blood pressure2008

    • Author(s)
      H. Yokoyama
    • Organizer
      Renal Week 2008 ASN's 41st Annual Meeting&Scientifie Exposition
    • Place of Presentation
      Philadelphia
    • Related Report
      2008 Annual Research Report
  • [Presentation] ループス腎炎 ISN/RPS2003 V型の問題点2008

    • Author(s)
      横山 仁
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] ループス腎炎ISN/RPS 2003分類に基づいた予後推定と治療指針2008

    • Author(s)
      横山 仁
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] ISN/RPS2003分類によるループス糸球体腎炎の解析2008

    • Author(s)
      横山 仁
    • Organizer
      第18回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急速進行性腎炎症候群(RPGN)の臨床病理学的検討2008

    • Author(s)
      井村淳子
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] ネフローゼ症候群における寛解導入・維持療法の比較検討2008

    • Author(s)
      藤本圭司
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 過去30年間のループス糸球体腎炎の検討2008

    • Author(s)
      奥山 宏
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎移植後1年で間質線維化の急速な進行がみられた1例2008

    • Author(s)
      渥美浩克
    • Organizer
      移植腎病理研究会・第12回学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] eGFRを用いた腎機能とメタボリック症候群因子の評価:腎機能保持に何が有効か?2008

    • Author(s)
      横山 仁
    • Organizer
      第41回日本臨床腎移植学会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腎移植後に発症したEBV関連PTLDの2例2008

    • Author(s)
      渥美浩克
    • Organizer
      第41回日本臨床腎移植学会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biocompatibility and permeability of dialyzer membranes do not affect anemia, erythropoietin dosage or mortality in Japanese patients on chronic non-reuse hemodialysis: a prospective cohort study from the J-DOPPS II study.2007

    • Author(s)
      Yokoyama H
    • Organizer
      Annual meeting American Society of Nephrology
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of preprandial once-a-day administration of cyclosporine(CyA)for steroid resistant nephrotic syndrome(SRNS)2007

    • Author(s)
      Saito T
    • Organizer
      ASN Renal Week in San Francisco
    • Place of Presentation
      San Francisco
    • Related Report
      2007 Annual Research Report
  • [Presentation] MCNSに対するMPT+低用量PSL+低用量CsA療法とMPT+PSL療法の比較検討2007

    • Author(s)
      藤本圭司
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] 過去30年間のループス糸球体腎炎の検討2007

    • Author(s)
      奥山 宏
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] 死体腎移植のPrimary nonfunction(PNF)症例における虚血/再灌流障害の重要性2007

    • Author(s)
      今村秀嗣
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] 妊婦高血圧症に伴うネフローゼ症候群における巣状分節性糸球体硬化病変2007

    • Author(s)
      渥美浩克
    • Organizer
      第50回日本腎臓学会総会
    • Place of Presentation
      浜松
    • Related Report
      2007 Annual Research Report
  • [Presentation] 虚血/再灌流障害が原因と考えられた死体腎移植後primary nonfunctionの3症例2007

    • Author(s)
      今村秀嗣
    • Organizer
      移植腎病理研究会・第11回学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 微小変化から巣状糸球体硬化症に至ったPodocin遺伝子異常陰性の母子例2007

    • Author(s)
      渥美浩克
    • Organizer
      第37回日本腎臓学会西部学術大会
    • Place of Presentation
      福井
    • Related Report
      2007 Annual Research Report
  • [Presentation] レジオネラ肺炎を契機に肉眼的血尿による急性尿細管壊死を呈したIgA腎症の1例2007

    • Author(s)
      井村淳子
    • Organizer
      第37回日本腎臓学会西部学術大会
    • Place of Presentation
      福井
    • Related Report
      2007 Annual Research Report
  • [Presentation] 短期間に特発性細菌性腹膜炎を頻回発症した肝硬変合併CAPDの1例2007

    • Author(s)
      木村庄吾
    • Organizer
      第37回日本腎臓学会西部学術大会
    • Place of Presentation
      福井
    • Related Report
      2007 Annual Research Report
  • [Presentation] 結節性硬化症に腎血管筋脂肪腫とオンコサイト様乳頭状腎細胞癌を合併した-症例2007

    • Author(s)
      藤本圭司
    • Organizer
      第37回日本腎臓学会西部学術大会
    • Place of Presentation
      福井
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血漿交換療法が有効であった急性リンパ性白血病に合併した重症高脂血症の1成人例2007

    • Author(s)
      中川 卓
    • Organizer
      第28回日本アフェレシス学会学術大会
    • Place of Presentation
      久留米
    • Related Report
      2007 Annual Research Report
  • [Book] Annual review 2010:ヒト膜性腎症の原因抗原:neutral endopeptidaseとM-type phospholopase A2 receptor2010

    • Author(s)
      横山仁, 他
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report
  • [Book] 専門医のための腎臓病学 第2版:膜性腎症2009

    • Author(s)
      横山仁, 他
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 専門医のための腎臓病学 第2版 7.膜性腎症2009

    • Author(s)
      横山仁
    • Total Pages
      621
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] (6)ネフローゼ症候群の治療法 成人, やさしい ネフローゼ症候群の自己管理2008

    • Author(s)
      横山 仁
    • Total Pages
      91
    • Publisher
      医薬ジャーナル
    • Related Report
      2008 Annual Research Report
  • [Book] 内科学 第九版2007

    • Author(s)
      横山 仁,
    • Total Pages
      2008
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Book] B全身性疾患に伴う糸球体疾患 1ループス腎炎, 腎疾患・透析最新の治療2008-20102007

    • Author(s)
      横山 仁
    • Total Pages
      438
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] III電解質異常の原因、病態生理と対策 1 血清カリウム 5 腎不全, 身につく水・電解質と酸塩基平衡 症例満載!基礎から学ぶ臨床輸液2007

    • Author(s)
      横山 仁
    • Total Pages
      222
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] 膜性腎症, 腎不全治療マニュアル2007

    • Author(s)
      横山 仁
    • Total Pages
      333
    • Publisher
      日本透析医会
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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