Chronic kidney disease (CKD) as a risk factor for cardiovascular diseases: investigation on pathogenesis and development of therapeutic strategy
| Project/Area Number |
19590969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
KASHIHARA Naoki Kawasaki Medical School, 医学部, 教授 (10233701)
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| Co-Investigator(Kenkyū-buntansha) |
KOMAI Norio 川崎医科大学, 医学部, 講師 (40368626)
SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 慢性腎臓病(CKD) / 生活習慣病 / 心血管病 / メタボリックシンドローム / 肥満 / レニン・アンジオテシン系 / 高血圧 / 血管内皮障害 / 慢性腎臓病 / アンジオテンシンII / 虚血 / アルブミン尿 / 一酸化窒素 / 酸化ストレス / 2光子レーザー顕微鏡 / 内皮機能障害 / 糖尿病性腎症 |
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| Research Abstract |
本邦で慢性腎臓病(Chronic Kidney Disease : CKD)が増加している。その主因は糖尿病、肥満、メタボリックシンドローム等の生活習慣病の増加と高齢化である。CKDは腎不全をもたらすだけでなく、心血管病(CVD)の強い危険因子でもある。本研究では、まずCKDの発症・進展機構の詳細を解明した。特になぜアルブミン尿が出現しCVDを合併するのか、その機構を明らかにした。本研究で得られたCKDの基盤病態の理解は、本症の予防と治療法立案に貢献するものである。
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Report
(3 results)
Research Products
(27 results)
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[Presentation] Angiotensin II Type 1 Receptor Blocker Ameliorates Uncoupled Endothelial Nitric Oxide Synthase in Rats with Streptozotocine Induced Diabetic Nephropathy2008
Author(s)
Satoh M, Fujimoto S, Haruna Y, Yada T,Kuwabara A, Nagasu H,Yorimitsu D, Namikoshi T, Tomita N, Sasaki T, Kashihara N
Organizer
American Society of Nephrology 41st Annual Meeting & Scientific Exposition
Place of Presentation
Philadelphia, Pennsylvania
Year and Date
2008-11-06
Related Report
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[Presentation] Oral adsorbent AST-120 ameliorates endothelial dysfunction and alleviates oxidative stress in aorta independent of renal function in subtotally nephrectomized rats2008
Author(s)
Namikoshi T, Tomita N, Satoh M, Sakuta T, Kuwabara A, Nagasu H, Yorimitsu D, Higuchi Y,Nishijima F, Kashihara N
Organizer
American Society of Nephrology 41st Annual Meeting & Scientific Exposition
Place of Presentation
Philadelphia, Pennsylvania
Year and Date
2008-11-06
Related Report
-
[Presentation] Angiotensin II Type 1Receptor Blocker Ameliorates Uncoupled Endothelial Nitric Oxide Synthase in Rats with Streptozotocine Induced Diabetic Nephropathy.2008
Author(s)
Minoru Satoh, Sohachi Fujimoto, Yoshisuke Haruna, Toyotaka Yada, Atsunori Kuwabara, Hajime Nagasu, Daisuke Yorimitu, Tamehachi Namikoshi, Naruya Tomita, Tamaki Sasaki, Naoki Kashihara
Organizer
American Society of Nephrology 41st Annual Meeting & Scientific Exposition
Place of Presentation
Philadelphia, Pennsylvania
Year and Date
2008-11-06
Related Report
-
[Presentation] Oral adsorbent AST-120 ameliorates endothelial dysfunction and alleviates oxidative stress in aorta independent of renal function in subtotally nephrectomized rats.2008
Author(s)
Tamehachi Namikoshi, Naruya Tomita, Minoru Satoh, Takeo Sakuta, Atsunori Kuwabara, Hajime Nagasu, Daisuke Yorimitsu, Yuusuke Higuchi, Fuyuhiko Nishijima, Naoki Kashihara
Organizer
American Society of Nephrology 41st Annual Meeting & Scientific Exposition
Place of Presentation
Philadelphia, Pennsylvania
Year and Date
2008-11-06
Related Report
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