ADMA metabolism and microvascular damage in chronic renal diseases
| Project/Area Number |
19590971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
OKUDA Seiya Kurume University, 医学部, 教授 (80158823)
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| Co-Investigator(Kenkyū-buntansha) |
上田 誠二 久留米大学, 医学部, 講師 (80322593)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 慢性腎臓病 / CKD / 一酸化窒素 / 内皮機能障害 / 蛋白尿 / ADMA DDAH / DDAH / ADMA / 心血管病 / NO |
|---|
| Research Abstract |
Asymmetric dimethylarginine(ADMA)は一酸化窒素(NO)の内因性合成阻害物質で、血管内皮機能障害により心血管病に密接に関わる。慢性腎臓病(CKD)では血中ADMA 濃度が上昇し、このことがCKDで頻度が増加する心血管病に関わると考えられる。一方、CKDにおける腎機能障害の進行にも内皮機能は重要と思われ、CKD患者では蛋白尿、腎機能低下に伴ってADMAが増加している。本研究ではCKDモデルラットにADMAの分解酵素であるDDAHを強制発現させ、ADMAを抑制することにより、腎機能、蛋白尿および腎組織病変も著明に改善することを明らかにし、ADMA-DDAH系をターゲットにした治療がCKD治療に有望であることを示した。
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischemia in early phase of diabetic nephropathy.2009
Author(s)
Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S.
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Journal Title
Nephrol Dial Transplant. 24
Pages: 1162-1169
Related Report
Peer Reviewed
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[Journal Article] Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats.2009
Author(s)
Fujimura T, Yamagishi S, Ueda S, Fukami K, Shibata R, Matsumoto Y, Kaida Y, Hyayashida A, Koike K, Matsui T, Nakamura K, Okuda S.
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Journal Title
Nephrol Dial Transplant. 24
Pages: 1397-1406
Related Report
Peer Reviewed
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[Journal Article] Circulating Matrix Metalloproteinase-2 is an independent correlate of proteinuria in patients with chronic kidney disease.2008
Author(s)
Nagano M, Fukami K, Yamagishi SI, Ueda S, Kaida Y, Matsumoto T, Yoshimura J, Hazama T, Takamiya Y, Kusumoto T, Gohara S, Tanaka H, Adachi H, Okuda S.
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Journal Title
Am J Nephrol. 29
Pages: 109-115
Related Report
Peer Reviewed
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[Journal Article] Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.2007
Author(s)
Kaneyuki U, Ueda S, Yamagishi SI, Kato S, Fujimura T, Shibata R, Hayashida A, Yoshimura J, Kojiro M, Oshima K, Okuda S.
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Journal Title
Vascul Pharmacol. 46
Pages: 286-292
Related Report
Peer Reviewed
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[Journal Article] Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients.2007
Author(s)
Tanaka M, Komatsu N, Terakawa N, Yanagimoto Y, Oka M, Sasada T, Mine T, Gouhara S, Shichijo S, Okuda S, Itoh K.
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Journal Title
Oncol Rep. 18
Pages: 161-166
Related Report
Peer Reviewed
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[Journal Article] Mesangiolytic glomerulopathy after radiotherapy and chemotherapy of gastric lymphoma.2007
Author(s)
Yoshimura J, Kato S, Tamaki K, Kohno K, Kaneyuki U, Maeda M, Saikusa-Itoh Y, Hayashida A, Iida S, Suefuji H, Okuda S.
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Journal Title
Intern Med. 46(22)
Pages: 1861-1865
NAID
Related Report
Peer Reviewed
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[Journal Article] Nodular Glomerulosclerosis in patients without any manifestation of diabetes mellitus.2007
Author(s)
Sanai T, Okuda S, Yoshimitsu T, Oochi N, Kumagai H, Katafuchi R, Harada A, Chihara J, Abe T, Nakamoto M, Hirakata H, Onoyama K, Iida M.
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Journal Title
NEPHROLOGY 12
Pages: 69-73
Related Report
Peer Reviewed
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