Elucidation of pathophysiological roles of integrins and therapeutic application by regulating integrins in chronic kidney disease

• Project/Area Number: 19590972
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: TAMURA Masahito University of Occupational and Environmental Health, Japan, 大学病院, 准教授 (40330980)
• Co-Investigator(Kenkyū-buntansha): SERINO Ryota 産業医科大学, 医学部, 助教 (00309957)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: インテグリン / 慢性腎臓病 / Focal adhesion kinase / 細胞接着分子 / 慢性腎炎 / FAK

Research Abstract

We investigated the modulatory effects of extracellular matrix (ECM) accumulation on the expression of cell adhesion molecules involved in the progression of renal diseases. Our results suggest that accumulation of pathological ECM components such as type I and III collagens might play a role in the progression of glomerular diseases by enhancing ICAM-1 expression and leukocyte adhesion to mesangial cells.

Research Products

• [Journal Article] Renoprotective effects of telmisartan in patients with advanced chronic kidney disease. (2010)
  • Author(s): TokunagaM, KabashimaN, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Fujimoto Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y, Tamura M
  • Journal Title: Clin Nephrol 73(2) Pages: 139-146
  • Peer Reviewed
• [Journal Article] An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. (2010)
  • Author(s): Miyamoto T, Tamura M, Kabashima N, Serino R, Shibata T, Furuno Y, Miyazaki M, Baba R, Sato N, Doi Y, Okazaki M, Otsuji Y
  • Journal Title: Nephrol Dial Transplant 25(4) Pages: 1109-1119
  • Peer Reviewed
• [Journal Article] Minimal change nephrotic syndrome in a patient with strongyloidiasis. (2010)
  • Author(s): Miyazaki M, Tamura M, Kabashima N, Serino R, Shibata T, Miyamoto T, Furuno Y, Nishio T, Ohara J, Sakurai T, Otsuji Y:
  • Journal Title: Clin Exp Nephrol (in press)
  • NAID: 10027706847
  • Peer Reviewed
• [Journal Article] Renoprotective effects of telmisartan in patients with advanced chronic kidney disease. (2010)
  • Author(s): Tokunaga M, et al.
  • Journal Title: Clin Nephrol 73 Pages: 139-146
  • Peer Reviewed
• [Journal Article] An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing. (2010)
  • Author(s): Miyamoto T, et al.
  • Journal Title: Nephrol Dial Transplant (In press)
  • Peer Reviewed
• [Journal Article] Minimal change nephrotic syndrome in a patient with strongyloidiasis. (2010)
  • Author(s): Miyazaki M, et al.
  • Journal Title: Clin Exp Nephrol (In press)
  • Peer Reviewed
• [Journal Article] A case report of steroid-resistant ANCA-related vasculitis successfully treated by mizoribine in a hemodialysis patient. (2009)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Fujimatsu S, Muta T, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Ther Aphre Dial 13(1) Pages: 77-79
  • Peer Reviewed
• [Journal Article] Electromagnetic Interference with a bipolar pacemaker by an induction heating (IH) rice cooker. (2009)
  • Author(s): Nagatomo T, Abe H, Kohno R, Toyoshima T, Fujimoto H, Kondo S, Kabashima N, Takeuchi M, Tamura M, Okazaki M, Otsuji Y
  • Journal Title: Int Heart J 50(1) Pages: 133-137
  • NAID: 130001909883
  • Peer Reviewed
• [Journal Article] Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. (2009)
  • Author(s): Shibata T, Tamura M, Kabashima N, Serino R, Tokunaga M, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Life Sci 84 Pages: 725-731
  • Peer Reviewed
• [Journal Article] Hepatic angiosarcoma-a rare liver tumor in a hemodialysis patient. (2009)
  • Author(s): Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y
  • Journal Title: Clin Nephrol 71(5) Pages: 590-592
  • Peer Reviewed
• [Journal Article] A case report of steroid-resistant ANCA-related vasculitis successfully treated by mizoribine in a hemodialysis patient. (2009)
  • Author(s): Tokunaga M, et al.
  • Journal Title: Ther Aphre Dial 13 Pages: 77-79
  • Peer Reviewed
• [Journal Article] Electromagnetic Interference with a bipolar pacemaker by an induction heating (IH) rice cooker. (2009)
  • Author(s): Nagatomo T, et al.
  • Journal Title: Int Heart J 50 Pages: 133-137
  • Peer Reviewed
• [Journal Article] Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. (2009)
  • Author(s): Shibata T, et al.
  • Journal Title: Life Sci 84 Pages: 725-731
  • Peer Reviewed
• [Journal Article] Hepatic angiosarcoma - a rare liver tumor in a hemodialysis patient. (2009)
  • Author(s): Matsumoto M, et al.
  • Journal Title: Clin Nephrol 71 Pages: 590-592
  • Peer Reviewed
• [Journal Article] 中高度腎機能障害合併高血圧例における長時間作用型Ca拮抗薬アゼルニジピンの効果 (2009)
  • Author(s): 宮崎三枝子, 他
  • Journal Title: Therapeutic Res 30 Pages: 1989-1994
  • Peer Reviewed
• [Journal Article] A case report of steroid-resistant anca-related vasculitis successfully treated by mizoribine in a hemodialysis patient. (2009)
  • Author(s): Tokunaga M, et al.
  • Journal Title: Ther Aphre Dial (In press)
  • Peer Reviewed
• [Journal Article] Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. (2009)
  • Author(s): Shibata T, et al.
  • Journal Title: Life Sci (In press)
  • Peer Reviewed
• [Journal Article] Hepatic angiosarcoma - a rare liver tumor in a hemodialysis patient. (2009)
  • Author(s): Matsumoto M, et al.
  • Journal Title: Clin Nephrol (In press)
  • Peer Reviewed
• [Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. (2008)
  • Author(s): Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y
  • Journal Title: Br J Pharmacol 153(3) Pages: 439-447
  • Peer Reviewed
• [Journal Article] Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient (2008)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Clin Nephrol 69(5) Pages: 393-394
  • Peer Reviewed
• [Journal Article] Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient. (2008)
  • Author(s): Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Takeuchi M, Abe H, Okazaki M, Otsuji Y
  • Journal Title: Clin Nephrol 70(5) Pages: 445-446
  • Peer Reviewed
• [Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. (2008)
  • Author(s): Takemasa H, et al.
  • Journal Title: Br J Pharmacol 153 Pages: 439-447
  • Peer Reviewed
• [Journal Article] Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient. (2008)
  • Author(s): Tokunaga M, et al.
  • Journal Title: Clin Nephrol 69 Pages: 393-394
  • Peer Reviewed
• [Journal Article] Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient. (2008)
  • Author(s): Tokunaga M, et al.
  • Journal Title: Clin Nephrol 70 Pages: 445-446
  • Peer Reviewed
• [Journal Article] PTEN reduces cuff-induced neointima formation and proinflammatory cytokines. (2007)
  • Author(s): Koide S, Okazaki M, Tamura M, Ozumi K, Takatsu H, Kamezaki F, Tanimoto A, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y
  • Journal Title: Am J Physiol Heart Circ Physiol 292(6)
  • Peer Reviewed
• [Journal Article] PTEN reduces cuff-induced neointima formation and proinflammatory cytokines (2007)
  • Author(s): Koide S
  • Journal Title: Am J Physiol Heart Circ Physiol 292
  • Peer Reviewed
• [Journal Article] The PHSRN sequence reduces inhibitory effects of conventional peritoneal dialysissolutions on integrin-mediated wound healing of rat peritoneal mesothelial cells (2007)
  • Author(s): Miyamoto T
  • Journal Title: J Am Soc Nephrol 18
  • Peer Reviewed
• [Journal Article] Effects of icodextrin on cell adhesion molecules in peritoneal mesothelial cells (2007)
  • Author(s): Tamura M
  • Journal Title: J Am Soc Nephrol 18
  • Peer Reviewed
• [Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome (2007)
  • Author(s): Takemasa H
  • Journal Title: Br J Phar 153 Pages: 439-447
  • Peer Reviewed
• [Journal Article] 脳腱黄色腫に微小変化型ネフローゼ症候群を合併した1例 (2007)
  • Author(s): 松本 美香
  • Journal Title: 日本内科学会誌 96 Pages: 150-152
  • Peer Reviewed
• [Journal Article] 適正腹膜透析とエビデンス・透析液と生体適合性・臨床 (2007)
  • Author(s): 田村 雅仁
  • Journal Title: 臨床透析 23 Pages: 1571-1579
  • Peer Reviewed
• [Journal Article] C-reactive protein induces human mesangial cell proliferation via phosphoIation of protein kinase C and up-reation of cclin D1 (2007)
  • Author(s): Tokunaga M
  • Journal Title: J Am Soc Nephrol 18
  • Peer Reviewed
• [Journal Article] Alpha 2 beta 1 hltegrin regulates expression of cell adhesion molecules in mesangial cells (2007)
  • Author(s): Tokunaga M
  • Journal Title: J Am Soc Nephrol 18
  • Peer Reviewed
• [Journal Article] Efficacy and safety of telmisartan for advanced chronic renal insufficiency (2007)
  • Author(s): Tokunaga M
  • Journal Title: J Am Soc Nephrol 18
  • Peer Reviewed
• [Journal Article] Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperarathyroidism in a continuous ambulato peritoneal dialsis patient
  • Author(s): Tokunaga M
  • Journal Title: Clin Nephrol (In press)
  • Peer Reviewed
• [Presentation] Effects of Icodextrin onthe Integrin-Mediated Wound Healing of Peritoneal Mesothelial Cells (2009)
  • Author(s): Tamura M, et al.
  • Organizer: Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-10-31
• [Presentation] Effects of icodextrin on the integrin-mediated wound healing of peritoneal mesothelial cells. (2009)
  • Author(s): Tamura M, et al.
  • Organizer: 42nd Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA
  • Year and Date: 2009-10-31
• [Presentation] Protective effects of an integrin-activating peptide, PHSRN, on peritoneal wound healing in a rat model of acute peritoneal in jury (2008)
  • Author(s): 宮本哲
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-08
• [Presentation] Significance of undercarboxylated osteocalcin in patients with chronic kidney disease (2008)
  • Author(s): 宮崎三枝子
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-08
• [Presentation] Efficacy and safety of azelnidipine for advanced chronic renal insufficiency (2008)
  • Author(s): 宮崎三枝子
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-08
• [Presentation] Proteinuria and Reduced Glomerular Filtration Rate Increase Risk of Cardiovascular Disease in Japanese Adult Population : 5-year follow-up (2008)
  • Author(s): 徳永昌樹
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-07
• [Presentation] Add-on Spironolactone in Patients with Advanced Chronic Kidney Disease Treated with Angiotensin II Receptor Blockers (2008)
  • Author(s): 徳永昌樹
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-07
• [Presentation] Beneficial Effects of Pitavastatin on Albuminuria and Renal Function in Essential Hypertensive Patients with Chronic Kidney Disease (2008)
  • Author(s): 徳永昌樹
  • Organizer: 41 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Philadelphia
  • Year and Date: 2008-11-07
• [Presentation] 血液透析患者におけるMizoribineの薬物血行動態 (2008)
  • Author(s): 田村雅仁
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] 動脈表在化によるアクセスを使用し血液透析導入を行った5例の左心機能低下例の検討 (2008)
  • Author(s): 椛島成利
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] シスタチンCと腎生検における糸球体硬化数の関係 (2008)
  • Author(s): 芹野良太
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] 中高度腎機能障害例におけるアゼルニジピンの効果 (2008)
  • Author(s): 宮崎三枝子
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] IGF-1によるメサンギウム細胞増殖に対するフルバスタチンの効果 (2008)
  • Author(s): 柴田達哉
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-06-01
• [Presentation] 妊娠に合併した微小変化型ネフローゼ症候群の検討 (2008)
  • Author(s): 宮崎三枝子
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Presentation] 慢性腎不全の急性増悪に対するhANPの効果 (2008)
  • Author(s): 柴田達哉
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Presentation] 中高度腎機能障害例におけるアンギオテンシン受容体拮抗薬とspironolactone併用療法の臨床効果と安全性 (2008)
  • Author(s): 徳永昌樹
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Presentation] メサンギウム細胞でのCD44を介したβ1 integrin発現の制御 (2008)
  • Author(s): 柴田達哉
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Presentation] メサンギウム細胞におけるβ1 integrinによる細胞接着分子発現の制御 (2008)
  • Author(s): 田村雅仁
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Presentation] 急性腹膜障害モデルにおけるインテグリン活性化ペプチドの創傷治癒促進効果 (2008)
  • Author(s): 宮本哲
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-30
• [Presentation] 血管病変形成における-酸化窒素合成酵素システムの血管保護作用 (2008)
  • Author(s): 古野由美
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-30
• [Presentation] 木村氏病に伴う腎症の検討 (2008)
  • Author(s): 古野由美
  • Organizer: 日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-30
• [Presentation] Alpha 2 beta 1 integrin induces ICAM-1 expression in human mesangial cells (2007)
  • Author(s): Tamura M
  • Organizer: 47th Annual Meeting of American Society for Cell Biology
  • Place of Presentation: Washington D.C.,USA
• [Presentation] 腹膜中皮細胞におけるicodextrinの細胞接着分子への影響 (2007)
  • Author(s): 田村 雅仁
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] メサンギウム細胞における細胞接着分子への発現 (2007)
  • Author(s): 田村 雅仁
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] Gitelman Syndromeの3症例 (2007)
  • Author(s): 芹野 良太
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] DFPPが奏効したstiff-Person症候群 (2007)
  • Author(s): 芹野 良太
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] メサンギウム細胞におけるβ1インテグリンを介した炎症関連遺伝子の発現 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] CRPがメサンギウム細胞増殖に与える影響 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] 血液透析患者におけるANCA関連血管炎に対するMizoribineの効果 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] 中高度腎機能障害例におけるテルミサルタンの効果 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] メサンギウム細胞におけるCD44を介したβ1インテグリンの発現 (2007)
  • Author(s): 柴田 達哉
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] IGF-1によるメサンギウム細胞増殖に対するフルバスタチンの効果 (2007)
  • Author(s): 柴田 達哉
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] 慢性腎不全の急性憎悪時におけるhANPの効果 (2007)
  • Author(s): 柴田 達哉
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] インテグリン活性化ペプチドによる腹膜中皮細胞の創傷治癒促進作用 (2007)
  • Author(s): 宮本 哲
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] IcodexthnのICAM-1発現への影響 (2007)
  • Author(s): 松本 美香
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] 心筋シンチによる透析導入時虚血性心疾患の検討 (2007)
  • Author(s): 松本 美香
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Presentation] CKD診療のトピックス (2007)
  • Author(s): 田村 雅仁
  • Organizer: 第2回産業医科大学循環器・腎臓病診連携の会
  • Place of Presentation: 北九州
• [Presentation] IgA腎症で扁摘術ステロイド併用により完全寛解に至った1例 (2007)
  • Author(s): 宮本 哲
  • Organizer: 第2回産業医科大学循環器・腎臓病診連携の会
  • Place of Presentation: 北九州
• [Presentation] Icodextrinの生体適合性の検討〜細胞接着分子への影響について (2007)
  • Author(s): 田村 雅仁
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Kt/Vを改善させる有効なPrAとは-CL-Gapを用いた解析 (2007)
  • Author(s): 椛島 成利
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] アクセスPTAがKt/vに与える影響-穿刺部位と狭窄部位との位置関係 (2007)
  • Author(s): 椛島 成利
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 当院において開発した血液透析用電子カルテシステムの使用経験 (2007)
  • Author(s): 椛島 成利
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Mizoribileが有効であった透析患者のANCA関連血管炎の1例 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 慢性腎不全の急性増悪に対するhANPの効果 (2007)
  • Author(s): 柴田 達哉
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] インテグリン活性化ペプチドの腹膜中皮創傷治癒促進効果 (2007)
  • Author(s): 宮本 哲
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 高齢透析患者で高ウイルス量C型肝炎に対しインターフェロン単独で治療し得た一症例 (2007)
  • Author(s): 宮崎 三枝子
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 左室駆出率低下例に動脈表在化を行い順調に血液透析導入し得た5症例 (2007)
  • Author(s): 宮崎 三枝子
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 血液透析導入時に肺クリプトコッカス症を合併した一症例 (2007)
  • Author(s): 古野 由美
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 心筋シンチによる新規血液透析導入時の心筋虚血の評価 (2007)
  • Author(s): 松本 美香
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] IcodextrinがICAM-1発現へ与える影響-Icodextrinの生体適合性の検討 (2007)
  • Author(s): 松本 美香
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 共通通信プロトコールを利用した電子カルテシステムの使用経験 (2007)
  • Author(s): 高橋 一久
  • Organizer: 第52回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 細胞接着分子による腹膜透析液生体適合性の細胞機能的解析 (2007)
  • Author(s): 田村 雅仁
  • Organizer: 2006年度腹膜機能リサーチ研究会報告会
  • Place of Presentation: 東京
• [Presentation] 血液透析患者におけるANCA関連血管炎に対するMizoribineの効果 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第17回九州・山ロループス腎炎治療研究会
  • Place of Presentation: 福岡
• [Presentation] 左室駆出率低下に動脈表在化をおこない血液透析を導入した5症例の検討 (2007)
  • Author(s): 椛島 成利
  • Organizer: 第11回アクセス研究会
  • Place of Presentation: 千葉
• [Presentation] 播種性糞線虫症により多彩な病態を呈し死亡した微小変化型ネフローゼ症候群の1剖検例 (2007)
  • Author(s): 宮崎 三枝子
  • Organizer: 第37回日本腎臓学会西部学術集会
  • Place of Presentation: 福井
• [Presentation] Compound heterozygote mutationsにより発症したGitelman症候群の1例 (2007)
  • Author(s): 古野 由美
  • Organizer: 第137回北九州腎懇話会
  • Place of Presentation: 北九州
• [Presentation] Effects of icodextrin on cell adhesion molecules in peritoneal mesothelial cells (2007)
  • Author(s): Tamura M
  • Organizer: 40 th Annual Meeting of American Scciety of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] C-reactive protein induces human mesangial cell proliferation viahoshorlation of protein kinase C and up-reation of cyclin D1 (2007)
  • Author(s): Tokunga M
  • Organizer: 40 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Alpha 2 beta 1 integrin regUlates expression of cell adhesion molecules in mesangial cells (2007)
  • Author(s): Tokunaga M
  • Organizer: 40 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] Efficacy and safety of telmisartan for advanced chronic renal insufficiency (2007)
  • Author(s): Tokunaga M
  • Organizer: 40 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] The PHSRN sequence reduces inhibitory effects of conventional peritoneal dialysis solutions on illtegrin-mediated wound heahng of rat peritoneal mesothelial cells (2007)
  • Author(s): Miyamoto T
  • Organizer: 40 th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Francisco
• [Presentation] 透析導入期における深在性真菌感染症の検討 (2007)
  • Author(s): 徳永 昌樹
  • Organizer: 第40回九州人工透析研究会総会
  • Place of Presentation: 長崎
• [Presentation] 透析患者に発症した診断が困難であった肝腫瘍の一例 (2007)
  • Author(s): 松本 美香
  • Organizer: 第40回九州人工透析研究会総会
  • Place of Presentation: 長崎
• [Book] Icodextrin透析液の生体適合性、Annual Review腎臓2009 (2009)
  • Author(s): 田村雅仁、宮本哲
  • Publisher: 中外医学社
• [Book] Annual Review腎臓2009、Icodextrin透析液の生体適合性 (2009)
  • Author(s): 田村雅仁, 他
  • Total Pages: 288
  • Publisher: 中外医学社
• [Book] 腹膜透析2009新しく開発したPDカテーテル(JBS-2スリット型セミロングカテーテル)の性能評価 (2009)
  • Author(s): 椛島成利, 他
  • Total Pages: 561
  • Publisher: 東京医学社
• [Book] Icodextrin透析液の生体適合性、Annual Review 腎臓2009 (2009)
  • Author(s): 田村雅仁, 宮本哲
  • Total Pages: 8
  • Publisher: 中外医学社
• [Book] 特集「比べてわかる! 腎臓のはたらきと透析のはたらき」、透析ケア (2008)
  • Author(s): 徳永昌樹, 田村雅仁
  • Total Pages: 7
  • Publisher: メディカ出版
• [Book] 臨床透析、適正腹膜透析とエビデンス (2007)
  • Author(s): 田村 雅仁
  • Total Pages: 132
  • Publisher: 日本メディカルセンター