Elucidation of pathophysiological roles of integrins and therapeutic application by regulating integrins in chronic kidney disease
| Project/Area Number |
19590972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TAMURA Masahito University of Occupational and Environmental Health, Japan, 大学病院, 准教授 (40330980)
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| Co-Investigator(Kenkyū-buntansha) |
SERINO Ryota 産業医科大学, 医学部, 助教 (00309957)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インテグリン / 慢性腎臓病 / Focal adhesion kinase / 細胞接着分子 / 慢性腎炎 / FAK |
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| Research Abstract |
We investigated the modulatory effects of extracellular matrix (ECM) accumulation on the expression of cell adhesion molecules involved in the progression of renal diseases. Our results suggest that accumulation of pathological ECM components such as type I and III collagens might play a role in the progression of glomerular diseases by enhancing ICAM-1 expression and leukocyte adhesion to mesangial cells.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Renoprotective effects of telmisartan in patients with advanced chronic kidney disease.2010
Author(s)
TokunagaM, KabashimaN, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Fujimoto Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y, Tamura M
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Journal Title
Clin Nephrol 73(2)
Pages: 139-146
Related Report
Peer Reviewed
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[Journal Article] An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing.2010
Author(s)
Miyamoto T, Tamura M, Kabashima N, Serino R, Shibata T, Furuno Y, Miyazaki M, Baba R, Sato N, Doi Y, Okazaki M, Otsuji Y
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Journal Title
Nephrol Dial Transplant 25(4)
Pages: 1109-1119
Related Report
Peer Reviewed
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[Journal Article] Minimal change nephrotic syndrome in a patient with strongyloidiasis.2010
Author(s)
Miyazaki M, Tamura M, Kabashima N, Serino R, Shibata T, Miyamoto T, Furuno Y, Nishio T, Ohara J, Sakurai T, Otsuji Y:
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Journal Title
Clin Exp Nephrol (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] A case report of steroid-resistant ANCA-related vasculitis successfully treated by mizoribine in a hemodialysis patient.2009
Author(s)
Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Fujimatsu S, Muta T, Takeuchi M, Abe H, Okazaki M, Otsuji Y
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Journal Title
Ther Aphre Dial 13(1)
Pages: 77-79
Related Report
Peer Reviewed
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[Journal Article] Electromagnetic Interference with a bipolar pacemaker by an induction heating (IH) rice cooker.2009
Author(s)
Nagatomo T, Abe H, Kohno R, Toyoshima T, Fujimoto H, Kondo S, Kabashima N, Takeuchi M, Tamura M, Okazaki M, Otsuji Y
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Journal Title
Int Heart J 50(1)
Pages: 133-137
NAID
Related Report
Peer Reviewed
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[Journal Article] Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells.2009
Author(s)
Shibata T, Tamura M, Kabashima N, Serino R, Tokunaga M, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
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Journal Title
Life Sci 84
Pages: 725-731
Related Report
Peer Reviewed
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[Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.2008
Author(s)
Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y
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Journal Title
Br J Pharmacol 153(3)
Pages: 439-447
Related Report
Peer Reviewed
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[Journal Article] Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambulatory peritoneal dialysis patient2008
Author(s)
Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y
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Journal Title
Clin Nephrol 69(5)
Pages: 393-394
Related Report
Peer Reviewed
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[Journal Article] Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient.2008
Author(s)
Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Nakamata J, Takeuchi M, Abe H, Okazaki M, Otsuji Y
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Journal Title
Clin Nephrol 70(5)
Pages: 445-446
Related Report
Peer Reviewed
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[Journal Article] PTEN reduces cuff-induced neointima formation and proinflammatory cytokines.2007
Author(s)
Koide S, Okazaki M, Tamura M, Ozumi K, Takatsu H, Kamezaki F, Tanimoto A, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y
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Journal Title
Am J Physiol Heart Circ Physiol 292(6)
Related Report
Peer Reviewed
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