BMP/ALK/Smad1 signaling pathway and analysis of specifiobiomarkers in the progression of glomerulosclerosis
| Project/Area Number |
19590973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima (2008)
Research Institute for Production Development (2007) |
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Principal Investigator |
ABE Hideharu The University of Tokushima, 医学部・歯学部附属病院, 講師 (60399342)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hidenori 京都大学, 医学研究科, 医学研究科 (60232021)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 腎臓学 / 糖尿病性腎症 / コラーゲン / BMPs / Smad1 / ALK1 / バイオマーカー / 分子病態 / メサンギウム細胞 |
|---|
| Research Abstract |
糖尿病性腎症による腎不全・透析患者数は増加の一途にある。現行の治療法では、腎不全への進展をわずかに遅延させるのみである。より病態に基づいた効果的な腎症治療法の開発が必要である。そのため、腎糸球体硬化の形成に中心的な役割を果たす転写因子Smad1の活性化に関わり、糸球体硬化進行過程の病態を形成する2つの経路の調節機構をマウスを用いて解析した。その上で、糸球体硬化症の進展を追跡できる血中・尿中のバイオマーカーの選定を行った。
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Urinary Smadl is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy2008
Author(s)
Mima A, Arai H, Matsubara T, Abe H, Nagai K, Tamura Y, Torikoshi K, Araki M, Kanamori H, Takahashi T, Tominaga T, Matsuura M, Iehara N, Fukatsu A, Kita T, Doi T
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Journal Title
Diabetes 57(6)
Pages: 1712-22
Related Report
Peer Reviewed
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[Journal Article] Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephrapathy2007
Author(s)
Kanamori H, hiatsubara T, Mima A, Sumi E, Nagai K, Takahashi T, Abe H, Iehara N, Fukatsu A, Okamoto H, Kita T, Doi T, Arai H
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Journal Title
Biochem Biaphys Res Commun 360
Pages: 772-7
Related Report
Peer Reviewed
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[Presentation] BMP4/Smadl signaling is a key pathtvay in diabetic nephropathy2008
Author(s)
ominaga T, Abe H, Murakami T, Ar-aoka T, Shigeta R, Kishi S, Yoshikawa K, Matsuura M, Mima A, Doi T
Organizer
48th The American Society for Cell Biology Annual Meeting
Place of Presentation
San Francisco, U.S.A.
Related Report
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[Presentation] Role of Nitric Oxide Synthase(NOS)in the Progression of Diabetic Nephropathy2007
Author(s)
Kanamori H, Matsubara T, Mima A, Sumi E, Nagai K, Takahashi T, Abe H, Iehara N, Fukatsu A, Okamoto H, Kita T, Doi T, Arai H
Organizer
merican Society of Nephrology(ASN)Annual Meeting
Place of Presentation
San Francisco, U.S.A.
Related Report
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