Development of therapy targeting amyloid β protein oligomer in lipid rafts

• Project/Area Number: 19590976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Hirosaki University
• Principal Investigator: KAWARABAYASHI Takeshi Hirosaki University, 医学部附属病院, 講師 (90186156)
• Co-Investigator(Kenkyū-buntansha): SHOJI Mikio 弘前大学, 大学院・医学研究科, 教授 (60171021) ; WATANABE Mitsunori 弘前大学, 医学部附属病院, 助教 (90251107) ; 松原 悦朗 国立長寿センター(研究所), アルツハイマー病研究部, 室長 (70219468)
• Co-Investigator(Renkei-kenkyūsha): ETSURO Matsubara 弘前大学, 大学院・医学研究科, 准教授 (70219468)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経分子病態学 / リピドラフト / オリゴマー / アミロイド / アルツハイマー病 / アミロイドβ蛋白 / コレステロール / タウ / トランスジェニックマウス / シヌクレイン / GPIアンカー / CHO cell

Research Abstract

神経変性疾患モデルを用いてlipid raftsでのオリゴマー蓄積を検討した. 1. 培養細胞ではlipid rafts の蛋白の変化がAs前駆体の分布を変化させた, 2. APP発現マウスに高コレステロール食を投与すると脳Asの増加と共に脳lipid rafts分画中へのAsオリゴマーが増加した. 3. Tau発現マウスでは初期からtauが脳lipid raftsに高濃度に存在し, 加齢と共に増加しオリゴマーも認められた, 4. 新たに作成したα-synuclein発現マウスでも脳lipid raftsへのα-synuclein蓄積の増加を認めた, Lipid raftsは蛋白凝集体蓄積の共通開始部位であることが示された, lipid raftsにおけるオリゴマー制御は神経変性疾患の根本的治療法になりうると考えられた.

Research Products

• [Journal Article] Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese (2009)
  • Author(s): Kuwano R, Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, Odani S, Kuwano R.
  • Journal Title: Genomics 93 Pages: 441-448
  • Peer Reviewed
• [Journal Article] A chemical chaperone, sodium 4-phenyl butyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenicmice. Parkinsonism Relat Disord (2009)
  • Author(s): Ono K, Ikemoto M, Kawarabayashi T, Ikeda M, Nishinakagawa T, Hosokawa M, Shoji M, Takahashi M, Nakashima M
  • Journal Title: Epubahead of print
  • Peer Reviewed
• [Journal Article] An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis (2009)
  • Author(s): Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M
  • Journal Title: Intern Med, Epubahead of print
  • NAID: 130000121961
  • Peer Reviewed
• [Journal Article] Motor impairment and aberrant production of neurochemicals in human α-synuclein A30P+A53T transgenic mice with α-synuclein pathology (2009)
  • Author(s): Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M
  • Journal Title: Brain Res. 1250 Pages: 232-241
  • Peer Reviewed
• [Journal Article] GAB2 is not associated with late-onset Alzheimer's disease in Japanese (2009)
  • Author(s): Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K,Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
  • Journal Title: Eur J Hum Genet 17 Pages: 682-686
  • Peer Reviewed
• [Journal Article] Transthyretin accelerates vascular Aβ deposition in a mouse model of Alzheimer's disease (2009)
  • Author(s): Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S
  • Journal Title: Brain Pathol 19 Pages: 48-57
  • Peer Reviewed
• [Journal Article] Transthyretiri accelerates vascular Aβ deposition in a mouse model of Alzheimer's disease (2009)
  • Author(s): Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S
  • Journal Title: Brain Pathol 19 Pages: 48-57
  • Peer Reviewed
• [Journal Article] Motor impairment and aberrant production of neurochemicals in human a-synuclein A30P+A53T transgenic mice with α-synuclein pathology (2009)
  • Author(s): Ikeda M, Kawarabayashi T. Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y Nakazato Y, Okamoto K, Abe K, Shoji M
  • Journal Title: Brain Res 1250 Pages: 232-241
  • Peer Reviewed
• [Journal Article] A chemical chaperone, sodium 4-phenylbutyric acid, attenuate5 the pathogenic potency in human α-synuclein A30P+A53T transgenic mice (2009)
  • Author(s): Ono K, Ikemoto M, Kawarabayashi T, Ikeda M, Nishinakagawa T, Hosokawa M, Shoji M, Takahashi M, Nakashima M
  • Journal Title: Parkinsonism Relat Disord (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] An unusual case of chronic relapsing tetanus associatec with mandibular osteomyelitis (2009)
  • Author(s): Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M
  • Journal Title: Intern Med (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] GAB2 is not associated with late-onset Alzheimer's disease in Japanese (2009)
  • Author(s): Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
  • Journal Title: Eur J Hum Genet 17 Pages: 682-686
  • Peer Reviewed
• [Journal Article] Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese (2009)
  • Author(s): Kuwano R, Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, Odani S, Kuwano R
  • Journal Title: Genomics (in press)
  • Peer Reviewed
• [Journal Article] 神経疾患治療の進歩認知症の治療の進歩 (2009)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 神経治療学 (in press)
• [Journal Article] ダッチタイプおよびアイスランドタイプ遺伝性脳出血 (2009)
  • Author(s): 瓦林毅
  • Journal Title: 神経内科 70 Pages: 172-179
• [Journal Article] EBMに基づく認知症の薬物療法の評価 (2009)
  • Author(s): 東海林幹夫
  • Journal Title: 老年医学 47 Pages: 47-52
• [Journal Article] 認知症(高齢者), 睡眠とその障害 (2009)
  • Author(s): 針谷康夫, 東海林幹夫
  • Journal Title: Clinical Neuroscience 27 Pages: 203-205
• [Journal Article] Plasma biomarkers of Alzheimer's disease (2008)
  • Author(s): Kawarabayashi T, Shoji M
  • Journal Title: Curr Opin Psychiatry 21 Pages: 260-267
• [Journal Article] Microglial activation in brain lesions with tau deposits : comparison of human tauopathies and tau transgenic mice TgTauP301L (2008)
  • Author(s): Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, St. George-Hyslop P, Shoji M, Nakazato Y
  • Journal Title: Brain Res 1214 Pages: 260-267
  • Peer Reviewed
• [Journal Article] Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls (2008)
  • Author(s): Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M
  • Journal Title: Brain Res 121 Pages: 169-179
  • Peer Reviewed
• [Journal Article] Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction (2008)
  • Author(s): Kurata T, Hayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Kawarabayashi T, Takao Y, Ohta T, Harigaya Y, Manabe Y, Kamiya T, Shoji M, Abe K.
  • Journal Title: Neurol Res 30 Pages: 860-867
  • Peer Reviewed
• [Journal Article] A small trinucleotide expansion in the TBP gene gives rise to a sporadic case of SCA17 with abnormal putaminal findings on MRI (2008)
  • Author(s): Watanabe M, Monai N, Jackson M, Yamamoto-Watanabe Y, Ikeda Y, Suzuki C, Tomiyama M, Kawarabayashi T, Kimura T, Seino Y, Wakasaya Y, Miki Y, Matsubara E, Shoji M
  • Journal Title: Intern Med 47 Pages: 2179-2182
  • NAID: 130000079782
  • Peer Reviewed
• [Journal Article] Exacerbation of chronic pancreatitis induced by anticholinesterase medications in myasthenia gravis (2008)
  • Author(s): Tomiyama M, Arai A, Kimura T, Suzuki C, Watanabe M, Kawarabayashi T, Shoji M
  • Journal Title: Eur J Neurol 15
  • Peer Reviewed
• [Journal Article] Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter (2008)
  • Author(s): Arai A, Tomiyama M, Kannari K, Kimura T, Suzuki C, Watanabe M, Kawarabayashi T, Shen H, Shoji M
  • Journal Title: Synapse 62 Pages: 632-635
  • Peer Reviewed
• [Journal Article] A Novel Mutation in the Arylsulfatase A Gene Associated with Adult-Onset Metachromatic Leukodystrophy without Clinical Evidence of Neuropathy (2008)
  • Author(s): Suzuki C, Watanabe M, Tomiyama M,Sugimoto K, Nanba E, Jackson M, KimuraT, Seino Y, Wakasaya Y, KawarabayashiT, Miki Y, Yamamoto-Watanabe Y, Shoji M
  • Journal Title: Eur Neurol 60 Pages: 310-311
  • Peer Reviewed
• [Journal Article] Sendai virus-mediated gene transfer of GDNF reduces AIF translocation and ameliorates ischemic cerebral injury (2008)
  • Author(s): JJin G、Inoue M、Hayashi T、Deguchi K、Nagotani S、Zhang H、Wang X、Shoji M, Hasegawa M 、Abe K
  • Journal Title: Neurol Res 30 Pages: 731-739
  • Peer Reviewed
• [Journal Article] Plasma biomarkers of Alzheimer's disease (2008)
  • Author(s): Kawarabavashi T, Shoji M
  • Journal Title: Current Opinion of Psychiatry 21 Pages: 260-267
• [Journal Article] Microglial activation in brain lesions with tau deposits : comparison of human tauopathies and tau transgenic mice TgTauP301L (2008)
  • Author(s): Sasaki A, Kawarabavashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, St.George-Hyslop P, Shoji M, Nakazato Y
  • Journal Title: Brain Res 1214 Pages: 159-168
  • Peer Reviewed
• [Journal Article] Plasma antibodies to AB40 and AB42 in patients with Alzheimer's disease and normal controls (2008)
  • Author(s): Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M
  • Journal Title: Brain Res 1219 Pages: 169-179
  • Peer Reviewed
• [Journal Article] Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction (2008)
  • Author(s): Kurata T, Hayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Kawarabayashi T, Takao Y, Ohta T, Harigaya Y, Manabe Y, Kamiya T, Shoji M, Abe K
  • Journal Title: Neurol Res 30 Pages: 860-867
  • Peer Reviewed
• [Journal Article] A small trinucleotide expansion in the TBP gene gives rise to asporadic case of SCA17 with abnormal putaminal findings on MRI (2008)
  • Author(s): Watanabe M, Monai N, Jackson M, Yamamoto-Watanabe Y, Ikeda Y, Suzuki C, Tomiyama M, Kawarabayashi T, Kimura T, Seino Y, Wakasaya Y, Miki Y, Matsubara E, Shoji M
  • Journal Title: Intern Med 47 Pages: 2179-2182
  • Peer Reviewed
• [Journal Article] Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine -transporter (2008)
  • Author(s): Arai A, Tomiyama M, Kannari K, Kimura T, Suzuki C, Watanabe M, Kawarabayashi T, Shen H, Shoji M
  • Journal Title: Synapse 62 Pages: 632-635
  • Peer Reviewed
• [Journal Article] A Novel Mutation in the Arylsulfatase A Gene Associated with Adult-Onset Metachromatic Leukodystrophy without Clinical Evidence of Neuropathy. (2008)
  • Author(s): Suzuki C, Watanabe M, Tomiyama M, Sugimoto K, Nanba E, Jackson M, Kimura T, Seino Y, Wakasaya Y, Kawarabayashi T, Miki Y, Yamamoto-Watanabe Y, Shoji M
  • Journal Title: Eur Neurol 60 Pages: 310-311
  • Peer Reviewed
• [Journal Article] Sendai virus-mediated gene transfer of GDNF reduces AIFtranslocation and ameliorates ischemic cerebral injury (2008)
  • Author(s): Jin G、Inoue M, Hayashi T、Deguchi K、Nagotani S、Zhang H、Wang X、Shoji M、Hasegawa M、Abe K
  • Journal Title: Neurol Res 30 Pages: 731-739
  • Peer Reviewed
• [Journal Article] 研究成果から予防を考える5. 動物実験から予防を考える (2008)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: Modern Physician 28 Pages: 1477-1484
• [Journal Article] 動物モデルからみた神経変性疾患. 前頭側頭型認知症 (2008)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 神経内科 68 Pages: 119-128
• [Journal Article] 脂質管理による認知症の予防 (2008)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 分子脳血管病 7 Pages: 66-71
• [Journal Article] アルツハイマー病の最近め進歩アルツハイマー病の早期診断法 (2008)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 臨床検査 52 Pages: 281-288
• [Journal Article] Alzheimer病-分子標的治療への展望 (2008)
  • Author(s): 渡辺光法, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: 神経治療学 25 Pages: 19-23
• [Journal Article] アルツハイマー病のバイオマーカー (2008)
  • Author(s): 渡辺光法, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: カレントテラピー 26 Pages: 45-49
• [Journal Article] アルツハイマー病の新規バイオマーカーの開発 (2008)
  • Author(s): 渡辺光法, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: BIO Clinica 23 Pages: 47-51
• [Journal Article] 認知症のバイオマーカー (2008)
  • Author(s): 渡辺光法, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: 臨床と研究 85 Pages: 489-492
• [Journal Article] 多系統萎縮症 (2008)
  • Author(s): 渡辺光法, 木村珠喜, 鈴木千恵子, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: Modern Physician 28 Pages: 629-633
• [Journal Article] アルツハイマー病3診断と治療のためのバイオマーカー (2008)
  • Author(s): 渡辺光法, 瓦林毅, 冨山誠彦, 東海林幹夫
  • Journal Title: 治療学 42 Pages: 53-56
• [Journal Article] 認知症の臨床と病態 (2008)
  • Author(s): 東海林幹夫
  • Journal Title: 臨床神経学 48 Pages: 467-475
  • NAID: 10021924613
• [Journal Article] バイオマーカーはどこまで進歩したのか -脳脊髄液・血液マーカーの現状と課題- (2008)
  • Author(s): 東海林幹夫
  • Journal Title: 老年精神医学増刊-I 19 Pages: 64-69
• [Journal Article] レビー小体病. 高齢者神経疾患のトータルマネージメント (2008)
  • Author(s): 冨山誠彦, 東海林幹夫
  • Journal Title: Modern Physician 28 Pages: 703-706
• [Journal Article] アルツハイマー病発症病態基盤をなす神経毒性Aβオリゴマー (2008)
  • Author(s): 松原悦朗
  • Journal Title: 臨床神経学 48 Pages: 906-906
  • NAID: 10024898558
• [Journal Article] アルツハイマー病の抗体治療 (2008)
  • Author(s): 松原悦朗
  • Journal Title: 臨床検査 52 Pages: 297-301
• [Journal Article] 疾患と神経新生アルツハイマー病 (2008)
  • Author(s): 松原悦朗, 柳澤勝彦
  • Journal Title: Clinical Neuroscience 26 Pages: 866-868
• [Journal Article] Exacerbation of chronic pancreatitis induced by anticholinesterase medications in myasthenia gravis. (2008)
  • Author(s): Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K
  • Journal Title: Eur J Neurol 15
  • Peer Reviewed
• [Journal Article] Plasma biomarkers of Alzheimer's disease. (2008)
  • Author(s): Kawarabayashi T, Shoji M
  • Journal Title: Curr Opin Psychiatry 21 Pages: 260-267
• [Journal Article] Enhanced accumulation of phosphorylated α-synuclein in double transgenic mice expressing mutant βAPP and presenilin-1 (2007)
  • Author(s): Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, St.George-Hyslop P, Harigaya Y, Kamiya T, Shoji M, Abe K
  • Journal Title: J Neurosci Res 85 Pages: 2246-2252
  • Peer Reviewed
• [Journal Article] a gene product of PARK6, accumulates in α-synucleinopathy brains (2007)
  • Author(s): Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, KurataT, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K, PINK1
  • Journal Title: J Neurol Neurosurg Psychiatry 78 Pages: 653-654
  • Peer Reviewed
• [Journal Article] The Japanese Genetic Study Consortium for Alzheimer's Disease, Consortium Information: Members are listed in the cknowledgements. Genetic association of CTNNA3 with late-onset Alzheimer's disease in females (2007)
  • Author(s): Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
  • Journal Title: Hum Mol Genet 16 Pages: 2854-2869
  • Peer Reviewed
• [Journal Article] Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis (2007)
  • Author(s): Nagata T, Ilieva H, Murakami T, Shiote M, Narai H, hta Y, Hayashi T, Shoji M,Abe K.
  • Journal Title: Neurol Res 29 Pages: 767-771
  • Peer Reviewed
• [Journal Article] Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients (2007)
  • Author(s): Nagata T, Nagano I, Shiote M, Narai H, Murakami T, Hayashi T, Shoji M, Abe K
  • Journal Title: Neurol Res 29 Pages: 772-776
  • Peer Reviewed
• [Journal Article] Induction of platelet derived-endothelial cell growth factor in the brain after ischemia (2007)
  • Author(s): Hayashi T, Wang XQ, Zhang HZ, Deguchi K, Nagotani S, Sehara Y, Tsuchiya A, Nagai M, Shoji M, Abe K
  • Journal Title: Neurol Res 29 Pages: 463-468
  • Peer Reviewed
• [Journal Article] A ganglioside-induced toxic soluble As assembly. Itβ enhanced formation from Aβ bearing the Arctic mutation (2007)
  • Author(s): Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M, Yanagisawa K
  • Journal Title: J Biol Chem 282 Pages: 2646-2655
  • Peer Reviewed
• [Journal Article] A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene (2007)
  • Author(s): Matsubara E, Tsuchiya A, Minami N,Nishino I, appolla MA, Shoji M, Abe K.
  • Journal Title: Eur J Neurol 14 Pages: 819-822
  • Peer Reviewed
• [Journal Article] Two cases of spinocerebellar ataxia accompanied by involvement of the skeletal motor neuron system and bulbar palsy (2007)
  • Author(s): Ohta Y, Hayashi T, Nagai M, Okamoto M, Nagotani S, Nagano I, Ohmori N, Takehisa Y, Murakami T, Shoji M, Kamiya T, Abe K.
  • Journal Title: Intern Med 46 Pages: 751-755
  • NAID: 130000076727
  • Peer Reviewed
• [Journal Article] Asian origin for the worldwide-spread mutational event in Machado-Joseph disease (2007)
  • Author(s): Martins S, Calafell F, Gaspar C, Wong VC, Silveira I, Nicholson GA, Brunt ER, Tranebjaerg L, Stevanin G, Hsieh M, Soong BW, Loureiro L, Durr A, Tsuji S, Watanabe M, Jardim LB, Giunti P, Riess O, Ranum LP, Brice A, Rouleau GA, Coutinho P, Amorim A, Sequeiros J.
  • Journal Title: Arch Neurol 64 Pages: 1502-1508
  • Peer Reviewed
• [Journal Article] Familial amyloid polyneuropathy(Finnish type)in a Japanese family Clinical features and immunocytochemical studies (2007)
  • Author(s): Ikeda M, Mizushima K, Fujita Y, Watanabe M, Sasaki A, Makioka K, Enoki M, Nakamura M, Otani T, Takatama M, Okamoto K.
  • Journal Title: J Neurol Sci 252 Pages: 4-8
  • Peer Reviewed
• [Journal Article] Enhanced accumulation of phosphorylated α-synuclein in double transgenic mice expressing mutant βAPP and presenilin-1. (2007)
  • Author(s): Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, St. George-Hyslop P, Harigaya Y, Kamiya T, Shoji M, Abe K
  • Journal Title: J Neurosci Res 85 Pages: 2246-2252
  • Peer Reviewed
• [Journal Article] PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains. (2007)
  • Author(s): Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K
  • Journal Title: J Neurol Neurosurg Psychiatry 78 Pages: 653-654
  • Peer Reviewed
• [Journal Article] Plasma antibodies to Aβ40 and Aβ42 in patients with Alzheimer's disease and normal controls.
  • Author(s): Xu W, Kawarabavashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M
  • Journal Title: Brain Res in press
  • Peer Reviewed
• [Journal Article] Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.
  • Author(s): Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, St. George-Hyslop P, Shoji M, Nakazato Y
  • Journal Title: Brain Res in press
  • Peer Reviewed
• [Journal Article] Transthyretin accelerates vascular Aβ deposition in a mouse model of Alzheimer's disease.
  • Author(s): Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S
  • Journal Title: Brain Pathol in press
  • Peer Reviewed
• [Presentation] Accumulation of protein in lipid rafts in mouse models of neurodegenerative diseases (2009)
  • Author(s): Kawarabayashi T, Seino Y, Wakasaya Y, Takamura A, Nakahata N, Watanabe Y, Watanabe M, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-05-29
• [Presentation] Enhanced accumulation of phosphorylated α-synuclein in doubly transgenic mice expressing mutant βAPP and PS-1 (2009)
  • Author(s): Kurata T, Kawarabayashi T Ikeda Y, Murakami T, Miyazaki K, Morimoto N, Ota Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, St. George Hyslop P, Harigaya Y, Shoji M, Abe K
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Clinical and molecular genetic study of ataxia-ocular apraxia 2 andfunctional analyses of senataxin. (2009)
  • Author(s): Watanabe M, Fujimuro M, Jackson M, Yamamoto-Watanabe Y, Kawarabayashi T, Takamura A, Nakahata N,. Shirahama I, Wakasaya Y, Seino Y, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Analysis of factors that induCe neuronal death in tau transgenic mice (2009)
  • Author(s): Wakasaya Y, Kawarabayashi T, Seino Y, Takamura A, Nakahata N, Watanabe Y, Watanabe M, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Aβ amyloid accelerates accumulation of phosphorylated tau neuronal cytoplasm and processes of double transgenic mice (2009)
  • Author(s): Seino Y, Kawarabayashi T, Wakasaya Y, Takamura A, Nakahata N, Watanabe Y, Watanabe M, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Development of a novel predictive biological marker for amyloid β accumulation in the brain (2009)
  • Author(s): Takamura A, Kawarabavashi T, Shoji, M, Matsubara E
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Establishment of outpatient memory clinic in Hirosaki University Hospital (2009)
  • Author(s): Nakahata N, Kawarabavashi T, Seino Y, Wakasaya Y, Takamura A, Watanabe Y, Watanabe M, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Measurement of cystatin C in the cerebrospinal fluid of neurodegenerative disorders (2009)
  • Author(s): Yamamoto-Watanabe Y, Watanabe M, Akimoto H, Sugimoto K, Yasujima M, Jackson M, Kawarabavashi T Takamura A, Nakahata N, Shirahama I, Wakasaya,Y, Seino Y, Matsubara E, Shoji M
  • Organizer: 11th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] SPECT analysis is useful in differentiation of pure akinesia from early progressive supr'anuclear palsy (2009)
  • Author(s): Ikeda Y, Kurata T, Hayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Kawarabavashi T, Takao Y, Ohta T, Harigaya Y, Manabe Y, Kamiya T, Shoji M, Abe K
  • Organizer: 11th Meeting of Hirosaki International F orum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Tauopathyによる神経細胞死を誘導する因子の解析 (2008)
  • Author(s): 若佐谷保仁, 清野祐輔, 瓦林毅, 中畑直子, 渡辺光法, 東海林幹夫
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版ウエクスラー記憶検査法(WMS-R)の有用性 (2008)
  • Author(s): 中畑直子, 瓦林毅, 1若佐谷保仁, 渡辺光法, 東海林幹夫
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10
• [Presentation] 脳内AB蓄積予測マーカーの開発 (2008)
  • Author(s): 高村歩美, 瓦林毅, 道川誠, 東海林幹夫, 松原悦朗
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10
• [Presentation] Aβワクチン療法overviewと複合作用機序支持派からみたAβワクチン療法の展望. (2008)
  • Author(s): 松原悦既
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10
• [Presentation] 神経原線維変化, 神経細胞死を再現するタウマウスモデルの検討 (2008)
  • Author(s): 瓦林毅, 渡辺光法, 東海林幹夫
  • Organizer: 第6回神経科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-20
• [Presentation] CSF tau correlates with brain tau in tau transgenic mice (2008)
  • Author(s): Kawarabayashi T, Seino1Y, Wakasaya1Y, Watanabe M, Kimura1T, Suzuki C, Tomiyama M, Matsubara E, Ishiguro K, Westaway D, St.George-Hyslop P, Shoji M
  • Organizer: ICAD2008
  • Place of Presentation: Chicago
  • Year and Date: 2008-07-28
• [Presentation] 神経原線維変化と神経細胞死を再現するタウマウスモデルの作成 (2008)
  • Author(s): 瓦林毅, 清野祐輔, 若佐谷保仁, 渡辺光則, 木村珠喜, 鈴木千恵子, 審山誠彦, 東海林幹夫, 松原悦朗, 池田将樹, 針谷康夫
  • Organizer: 第50回日本老年医学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2008-06-20
• [Presentation] 抗アミロイド蛋白40特異抗体を用いたアミロイドアンギオパチーの免疫療法 (2008)
  • Author(s): 瓦林毅, 東海林幹夫
  • Organizer: 第92回弘前医学会総会
  • Place of Presentation: 弘前
  • Year and Date: 2008-06-15
• [Presentation] 脳脊髄液タウは脳タウ蓄積と相関する (2008)
  • Author(s): 瓦林毅, 清野祐輔, 若佐谷保仁, 渡辺光法, 木村珠喜, 鈴木千恵子, 冨山誠彦, 松原悦朗, 石黒幸一, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] 当科におけるもの忘れ外来と脳脊髄液診断の現状 (2008)
  • Author(s): 君佐谷保仁, 瓦林毅, 中畑直子, 清野祐輔, 渡辺光法, 木村珠喜, 鈴木千恵子, 冨山誠彦, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] Aβアミロイドはタウ蓄積を促進する (2008)
  • Author(s): 清野祐輔, 瓦林毅, 若佐省保仁, 渡辺光法, 木村珠喜, 鈴木千恵子, 冨山誠彦, 松原悦朗, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] アルツハイマー病の超早期バイオマーカー開発 (2008)
  • Author(s): 松原悦朗, 瓦林毅, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] アルツハイマー病発症病態基盤をなす神経毒性Aβオリゴマー (2008)
  • Author(s): 松原悦朗
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] L-Dopaによるパーキンソン病モデルラット線条体でのスパイン形態の変化 (2008)
  • Author(s): 木村珠喜, 冨山誠彦, 新井陽, 鈴木千恵子, 渡辺光法, 瓦林毅, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] プランペキソール内服患者における下肢浮腫について (2008)
  • Author(s): 冨山誠彦, 木村珠喜, 新井陽, 鈴木千恵子, 瓦林毅, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] 低酸素脳症の体性感覚誘発電位-中潜時成分と予後についての検討 (2008)
  • Author(s): 鈴木千恵子, 尾崎勇, 冨山誠彦, 瓦林毅, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] Ataxia-ocular apraxia2(AOA2)の臨床遺伝字的検討とsenataxinの機能解析 (2008)
  • Author(s): 渡辺光法, 藤室雅弘, 冨山誠彦, 瓦林毅, 鈴木千恵子, 木村珠喜, 三木康生, 若佐谷保仁, 清野祐輔, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] L-Dopa誘発性ジスキネジアは淡蒼球内節GABAA受容体刺激により生じる (2008)
  • Author(s): 新井陽, 冨山誠彦, 木村珠喜, 鈴木千恵子, 瓦林毅, 東海林幹夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] Clinical and molecular genetic study of ataxia-ocular apraxia 2 and functional analysis of senataxin. (2008)
  • Author(s): Watanabe M, Jackson M, Fujimuro M. Kawarabayashi T, Seino Y, Wakasaya Y, Yamamoto-Watanabe Y, Matsubara E, Shoii MClinical and molecular genetic study of ataxia-ocular apraxia 2 and functional analysis of senataxin
  • Organizer: the Society for Neuroscience, 38^h Annual Meeting
  • Place of Presentation: Washington D.C.
• [Presentation] Characterization of therapeutic antibody against Aβ oligomers for Alzheimer's disease. (2007)
  • Author(s): Sun H, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Morishima M, Saito Y, Murayama S, Ihara Y, Shoji M, Michikawa M, Matsubara E
  • Organizer: the Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-05
• [Presentation] Analysis of phosphorylation of tau in transgenic mice overexpressing GSK-3β. (2007)
  • Author(s): Ikeda M, Goris I, Sasaki A, Kawarabayashi T, Harigaya Y, Shoji M, Moechars D, Okamoto K
  • Organizer: the Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-05
• [Presentation] Cortical neuronal and glial pathology in TgTauP301L transgenic mice. (2007)
  • Author(s): Kawarabayashi T, Seino Y, Wakasaya Y, Watanabe M, Suzuki C, Tomiyama M, Matsubara E, Egashira N, Takahashi M, Fujiwara M, Carlson GA, Westaway D, St. George-Hyslop P, Shoji M
  • Organizer: the Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-04
• [Presentation] As oligomer : An essential therapeutic target for Alzheimer's disease (2007)
  • Author(s): Shoji M
  • Organizer: The 23^<rd> International Synmpsium on Cerebralk Blood Flow, Metabolism & Function
  • Place of Presentation: Osaka
  • Year and Date: 2007-05-22
• [Presentation] Niemann-Pick type C1遺伝子のloss of functionはtauopathyを促進する. (2007)
  • Author(s): 瓦林毅, 清野祐輔, 若佐谷保仁, 新井陽, 木村珠喜, 鈴木千恵子, 冨山誠彦, 村上哲郎, 倉田智子, 松原悦朗, 東海林幹夫
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] 超高齢者集団認知症検診におけるMini-Mental State Examination(MMSE)の妥当性の検討. (2007)
  • Author(s): 若佐谷保仁、清野祐輔、瓦林毅、三木康生、木村珠喜、鈴木千恵子、渡辺光法、冨山誠彦、桑野良三、東海林幹夫
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] Aβアミロイド蓄積は神経突起およびグリア細胞へのtau蓄積を促進する. (2007)
  • Author(s): 清野祐輔, 瓦林毅, 若佐谷保仁, 新井陽, 木村珠喜, 鈴木千恵子, 冨山誠彦, 村上哲郎, 倉田智子, 松原悦朗, 東海林幹夫
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] Cortical neuronal and glial pathology in TgTauP301L transgenic mice the Society for Neuroscience (2007)
  • Author(s): Kawarabayashi T, Seino Y, Wakasaya Y, Watanabe M, Suzuki C, Tomiyama M, Matsubara E, Egashira N, Takahashi M, Fujiwara M, Carlson GA, Westaway D, St.George-Hyslop P, Shoji M
  • Organizer: 37^<th> Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Characterization of therapeutic antibody against Aβ oligomers for Alzheimer's disease. the Society for Neuroscience (2007)
  • Author(s): Sun H, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Morishima M, Saito Y, Murayama S, Ihara Y, Shoji M, Michikawa M, Matsubara E
  • Organizer: 37^<th> Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Analysis of phosphorylation of tau in transgenic mice overexpressing GSK-3β. the Society for Neuroscience (2007)
  • Author(s): Ikeda M, Goris I, Sasaki A, Kawarabayashi T, Harigaya Y, Shoji M, Moechars D, Okamoto K
  • Organizer: 37th Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Analysis of transgenic mice overexpressing mutant tau and GSK-3β (2007)
  • Author(s): Ikeda M, Goris I, Sasaki A, Kawarabayashi T, Ishiguro K, Shoji M, Harigaya Y, Westaway D, St George-Hyslop P, Moechars D, Okamoto K
  • Organizer: IPA 2007 Osaka Silver Congress of the International Psychiatrics Association
  • Place of Presentation: Osaka
• [Presentation] Components of Lewy bodies (2007)
  • Author(s): Shoji M
  • Organizer: IPA 2007 Osaka Silver Congress of the International Psychiatrics Association
  • Place of Presentation: Osaka
• [Presentation] Analysis of amyloid angiopathy in Tg2576 Transgenic mouse model of Alzheimer's disease (2007)
  • Author(s): Kawarabayashi T, Seino Y, Wakasaya Y, Kimura T, Suzuki C, Tomiyama M, Matsubara E, Shoji M
  • Organizer: The 23^<rd> International Synmpsium on Cerebralk Blood Flow, Metabolism & Function
  • Place of Presentation: Osaka
• [Presentation] Multiple Sclerosis with chronic sialadenitis (2007)
  • Author(s): Suzuki C, Tomiyama M, Kawarabayashi T, Shoji M, Baba M
  • Organizer: 17th meeting of the European Neurological Society
  • Place of Presentation: Rhodes Greece
• [Presentation] Analysis of amyloid angiopathy in Tg2576 Transgenic mouse model of Alzheimer's disease. (2007)
  • Author(s): Kawarabayashi T, Seino Y, Wakasaya Y, Kimura T, Suzuki C, Tomiyama M, Matsubara E, Shoji M
  • Organizer: Brain'07 and Brain PET'07
  • Place of Presentation: Osaka
• [Presentation] Aβ accumulation causes potstsynaptic damage in Tg2576 mice. (2007)
  • Author(s): Wakasaya Y, Seino Y, Kawarabayashi T, Watanabe M, Suzuki C, Tomiyama M, Matsubara E, Shoji M
  • Organizer: 第26回日本認知症学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Aβ amyloid accelerates accumulation of tau in neuronal processes. (2007)
  • Author(s): Seino Y, Wakasaya Y, Kawarabayashi T, Watanabe M, Suzuki C, Tomiyama M, Matsubara E, Shoji M
  • Organizer: 第26回日本認知症学会学術集会
  • Place of Presentation: 大阪
• [Book] MCIと認知症-リスクファクター- Annual Review 2009 神経(柳澤信夫, 篠原幸人, 岩田誠, 清水輝夫, 寺本明編) (2009)
  • Author(s): 瓦林毅, 東海林幹夫
  • Publisher: 中外医学社
• [Book] アルツハイマー病.神経疾患最新の治療(小林祥泰, 水澤英洋) (2009)
  • Author(s): 東海林幹夫
  • Publisher: 南江堂, 東京
• [Book] MCIと認知症-リスクファクター-Annual Review 2009神経 (2009)
  • Author(s): 瓦林毅, 東海林幹夫
  • Publisher: 中外医学社
• [Book] 脳卒中はどんな症状ではじまるのか, からだの科学 (2009)
  • Author(s): 東海林幹夫, 清野祐輔, 若佐谷保仁, 瓦林毅
  • Publisher: 日本評論社
• [Book] ヘルペス脳炎. 今日の治療指針 (2009)
  • Author(s): 東海林幹夫
  • Publisher: 医学書院
• [Book] 特殊なアルツハイマー病遺伝性脳アミロイドーシス、ダッチタイプ遺伝性脳出血(HCHWA-D)日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 瓦林毅
  • Publisher: 日本臨床社
• [Book] 特殊なアルツハイマー病遺伝性脳アミロイドーシス、アイスランドタイプ遺伝性脳出血(HCHWA-I)日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 瓦林毅
  • Publisher: 日本臨床社
• [Book] アルツハイマー病. 神経疾患最新の治療 (2008)
  • Author(s): 東海林幹夫
  • Publisher: 南江堂
• [Book] アルツハイマー病の診断. 1) 診断基準3) b. b) AB日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 東海林幹夫
  • Publisher: 日本臨床社
• [Book] アルツハイマー病. 認知症テキストブック (2008)
  • Author(s): 東海林幹夫
  • Publisher: 中外医学社
• [Book] 認知症. 新版処方計画法. 綜合臨床2008年増刊号 (2008)
  • Author(s): 東海林幹夫
  • Publisher: 永井書店
• [Book] 認知症治療の最前線-ニコチン治療を中心として- (2008)
  • Author(s): 東海林幹夫
  • Publisher: メジカルビュー社
• [Book] Aβクリアランス経路を標的とした治療法の開発. 日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 松原悦朗
  • Publisher: 日本臨床社
• [Book] アルツハイマー病の新しい治療法の開発新規医薬品Aβ凝集抑制薬. 日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 松原悦朗
  • Publisher: 日本臨床社
• [Book] アルツハイマー病の診断生物学的マーカー検査脳脊髄液タウ日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 松原悦朗
  • Publisher: 日本臨床社
• [Book] Aβの化学構造. 日本臨床66巻増刊号1(通巻第929号)アルツハイマー病 (2008)
  • Author(s): 松原悦朗
  • Publisher: 日本臨床社
• [Book] Alzheimer 病のバイオマーカー(岩坪威編別冊) (2007)
  • Author(s): 瓦林毅, 東海林幹夫
  • Publisher: 医学のあゆみ 医歯薬出版株式会社
• [Book] アルツハイマー病. 神経難病のすべて~症状・診断から最先端治療福祉の実際まで(阿部康二) (2007)
  • Author(s): 瓦林毅, 東海林幹夫
  • Publisher: 新興医学
• [Book] 別冊 医学のあゆみ Alzheimer病のバイオマーカー (2007)
  • Author(s): 瓦林毅, 東海林幹夫
  • Total Pages: 6
  • Publisher: 医歯薬出版株式会社
• [Book] 神経難病のすべて〜症状・診断から最先端治療 フルツハイマー病. (2007)
  • Author(s): 瓦林毅, 東海林幹夫
  • Total Pages: 10
  • Publisher: 新興医学
• [Book] 軽度認知症障害(MCI):認知症に先手を打つ 5.生物学的マーカー. (2007)
  • Author(s): 瓦林毅, 東海林幹夫
  • Total Pages: 15
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~neurology/study02.html
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~neurology/study02.html
• [Patent(Industrial Property Rights)] ワクチンを蓄積する形質転換ダイズ植物およびその利用 (2008)
  • Inventor(s): 寺川輝彦, 長谷川久和, 石本政男, 内海成, 東海林幹夫, 瓦林毅
  • Industrial Property Rights Holder: 北興化学工業株式会社, 独立行政法人農業・食品産業技術総合研究機構, 国立大学法人京都大学, 国立大学法人弘前大学
  • Industrial Property Number: 2008-304006
  • Filing Date: 2008-11-28
• [Patent(Industrial Property Rights)] パーキンソン病モデルトランスジェニックマウス (2008)
  • Inventor(s): 東海林幹夫, 池田将樹, 山田秀一
  • Industrial Property Rights Holder: 北興化学工業株式会社, 独立行政法人農業・食品産業技術総合研究機構, 国立大学法人京都大学, 国立大学法人弘前大学
  • Acquisition Date: 2008-08-22