| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
In wild-type α-synuclein cells treated with rotenone, induction of unfolded protein response (UPR) markers were evident several hours before the induction of mitochondrial disruption and caspase-3 activation. On the other hand, the S129A mutant failed to activate UPRs. It seems plausible that α-synuclein toxicity is dependent on the phosphorylation at S129 that induces the UPRs.
|
