| Project/Area Number |
19591004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nihon institute of Medical Science |
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Principal Investigator |
YOSHIMURA Kazunori Nihon institute of Medical Science, 保健医療学部, 教授 (20158497)
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| Co-Investigator(Kenkyū-buntansha) |
亀谷 富由樹 (財)東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 (70186013)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMETANI Fuyuki (財)東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 (70186013)
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| Research Collaborator |
KADOYA Toshihiko 前橋工科大学, 工学部・生物工学科, 教授 (40551875)
SAKAMOTO Yasushi 埼玉医科大学, 医学部・中央研究施設, 施設長・教授 (80178582)
KITAMURA Kunio 埼玉医科大学, 保健医療学部・健康医療科学科, 教授 (70049857)
MIYAZAKI Takashi 埼玉医科大学, 医学部・地域医学医療センター, 助教 (30265417)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経病態生化学 / 神経再生促進 / マクロファージ / 神経栄養因子 / プロテオミクス / 神経再生促進作用 |
|---|
| Research Abstract |
We identified several kind of proteins related with signal transduction of oxidized galectin-1 in macrophages stimulated with oxidized galectin-1 by fluorescence two dimensional difference gel electrophoreis (2D DIGE). The proteins were arginase, GRP78, transaldolase, glia maturation factor, and malate dehydrogenase. We have been investigating about macrophages stimulated by oxidized galecin-1 in detail with Real Time RT-PCR, Western blot, Calcium Imaging, and proteome analysis.
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