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The role of ASIC for pathophysiology of migraine

Research Project

Project/Area Number 19591005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKeio University

Principal Investigator

SHIMIZU Toshihiko  Keio University, 医学部, 講師 (40265799)

Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords片頭痛 / TRPV1 / ASIC / ERK / diploic vein / MAPキナーゼ
Research Abstract

In this study, we investigated the role of acid sensing ion channel (ASIC) and the transient receptor potential vanilloid subfamily member 1 (TRPV1) for pathophysiology of migraine. In addition to vascular dysfunction, the neurogenic inflammation of the dura mater innervated by the trigeminal ganglion is considered to be related to migraine pathophysiology. We demonstrated the existence of the TRPV1 receptor in the dura mater and the trigeminal ganglion in this project. Furthermore, our data showed that the nociceptive stimulation of TRPV1 receptors in the dura mater caused the phosphorylation of ERK, which is in response to the noxious stimulation of peripheral TRPV1 receptors in the trigeminal ganglion in vivo. We also observed the phosphorylation of ERK in vitro. As such phosphorylation was found to occur rapidly after TRPV1 stimulation, we surmised that ERK phosphorylation can serve as sensitive marker of nociception at the level of the trigeminal ganglion. We also observed the developmental pattern of the diploic veins and the relationship between the diploic veins and the dural TRPV1 receptor. Many dural TRPV1 receptor immunoreactive nerve fibers were observed over the diploic veins and these finding indicated the possibility that heat from the diploic veins may affect to the threshold of the TRPV1 receptor

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (9 results) Book (1 results)

  • [Journal Article] Developmental and circulatory profile of the diploic veins2011

    • Author(s)
      Toriumi H, Shimizu T, Shibata M, Unekawa M, Tomita Y, Tomita M, Suzuki N
    • Journal Title

      Microvascular Res. Vol 81

      Pages: 97-102

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 片頭痛の病態研究および治療に関する最近の知見2011

    • Author(s)
      清水利彦,柴田護,鈴木則宏
    • Journal Title

      臨床神経学 51巻

      Pages: 103-109

    • NAID

      10031163984

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental and circulatory profile of the diploic veins2011

    • Author(s)
      Toriumi H, Shimizu T, et al
    • Journal Title

      Microvascular Research

      Volume: 81 Pages: 97-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経原性炎症のメカニズム研究.2008

    • Author(s)
      清水利彦
    • Journal Title

      カレントテラピー 26

      Pages: 887-890

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 頭痛 片頭痛を中心に.2008

    • Author(s)
      清水利彦
    • Journal Title

      実験治療 691

      Pages: 124-128

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 片頭痛の最新のトピックス-薬物治療の問題点と今後望まれる薬剤2008

    • Author(s)
      清水 利彦
    • Journal Title

      日薬理誌 131

      Pages: 210-214

    • NAID

      10024382193

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat2007

    • Author(s)
      Shimizu T, Toriumi H, Sato H, Shibata M, Nagata E, Gotoh K, Suzuki N
    • Journal Title

      Brain Res. Vol.1173

      Pages: 84-91

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat.2007

    • Author(s)
      Shimizu T
    • Journal Title

      Brain Res 1173

      Pages: 84-91

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Distribution and origin of TRPV1 receptor-containing nerve ffibers in the dura mater of rat2007

    • Author(s)
      Shimizu T
    • Journal Title

      Brain Res 1173

      Pages: 84-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 片頭痛の発症メカニズム説2007

    • Author(s)
      清水 利彦
    • Journal Title

      薬局 58

      Pages: 2175-2178

    • Related Report
      2007 Annual Research Report
  • [Presentation] 片頭痛における慢性化のメカニズム2010

    • Author(s)
      清水利彦
    • Organizer
      第38回日本頭痛学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳硬膜侵害刺激による三叉神経節神経細胞におけるERKリン酸化の経時変化2010

    • Author(s)
      岩下達雄,清水利彦
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] A型ボツリヌス毒素の三叉神経節におけるTRPV1 発現への影響-投与量による比較検討-2009

    • Author(s)
      清水利彦
    • Organizer
      第37回日本頭痛学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] A型ボツリヌス毒素の三叉神経節におけるTRPV1発現への影響-投与量による比較検討-2009

    • Author(s)
      清水利彦
    • Organizer
      第37回日本頭痛学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] The effect of Botulinum toxin type A on the TRPV1 receptor in the trigeminal ganglion of the rat2008

    • Author(s)
      清水利彦
    • Organizer
      European Headache and Migraine Trust International Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2008-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] The effect of Botulinum toxin type A on the TRPV1 receptor in the trige minal ganglion of the rat.2008

    • Author(s)
      Shimizu T
    • Organizer
      European Hea dache and Migraine Trust International Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2008-09-07
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] The effect of Botulinum toxin type A on the TRPVl receptor in the trigeminal ganglion of the rat.2008

    • Author(s)
      Shimizu T
    • Organizer
      European Headache and Migraine Trust International Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット脳硬膜におけるTRPV1陽性神経の起源について2007

    • Author(s)
      清水利彦
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-18
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] ラット脳硬膜におけるTRPV1陽性神経の起源につい2007

    • Author(s)
      清水 利彦
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Book] 6.片頭痛は脳梗塞のリスクですか?棚橋紀夫, 北川泰久(編).脳卒碗診療こんなときどうするQ&A2008

    • Author(s)
      清水 利彦
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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