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The development of a novel molecular targeting therapeutic intervention in HTLV-1-associated myelopathy(HAM)

Research Project

Project/Area Number 19591015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

YAMANO Yoshihisa  St.Marianna University School of Medicine, 難病治療研究センター, 准教授 (80445882)

Co-Investigator(Kenkyū-buntansha) 久保田 龍二  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (70336337)
有村 公良  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (20159510)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経病態免疫学 / HTLV-1 / HAM / CD4+CD25+CCR4+ / FoxP3 / CTLA-4 / Interferon-γ / interleukin-2 / Interleukin-17 / HTLV-I / CD4+CD25+ / CD28 / interferon-gamma
Research Abstract

HTLV-1関連脊髄症(HAM)は、HTLV-1感染細胞に起因した過剰な免疫応答がその主病態である。しかし、感染細胞の中でどのT細胞サブセットがその主原因細胞であるかまだ明らかにされていない。本研究では、HAMの新規な分子標的治療法を開発するために、感染細胞に着目して研究を進め、HAMの過剰な免疫応答を誘発している主病因細胞を同定した

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (30 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Activation of Synoviolin Promoter in Rheumatoid Synovial Cells by a Novel Transcription Complex of Interleukin Enhancer Binding Factor 3 and GA Binding Protein2009

    • Author(s)
      Izumi T., Fujii R., Izumi T., Nakazawa M., Yagishita N., Tsuchimochi K., Yamano Y, et.al.
    • Journal Title

      Arthritis Rheum 60(1)

      Pages: 63-72

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages2009

    • Author(s)
      Shimizu Y., Takamori A., Utsunomiya A., Kurimura M., Yamano Y. , et.al.
    • Journal Title

      Cancer Sci 100(3)

      Pages: 481-489

    • NAID

      10025143429

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Synoviolin Promoter in Rheumatoid Synovial Cells by a Novel Transcription Complex of Interleukin Enhancer Binding Factor 3 and GA Binding Protein2009

    • Author(s)
      Izumi T, et al
    • Journal Title

      Arthritis Rheum 60(1)

      Pages: 63-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-l in a subgroup of individuals at asymptomatic and smoldering stages2009

    • Author(s)
      Shimizu Y, et al
    • Journal Title

      Cancer Sci 100(3)

      Pages: 481-489

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease2008

    • Author(s)
      Grant C., Oh U., Yao K., Yamano Y., Jacobson S
    • Journal Title

      Blood 111(12)

      Pages: 5601-5609

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased prevalence of group A-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection tes2008

    • Author(s)
      Omurzakova N.A., Yamano Y., Sato T., Izumi T., Azakami K. , et.al.
    • Journal Title

      Molecular Medicine Report 1

      Pages: 869-87

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease.2008

    • Author(s)
      Grant C, et al
    • Journal Title

      Blood 111(12)

      Pages: 5601-5609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased prevalence of group A β-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection test.2008

    • Author(s)
      Omurzakova N. A., et al
    • Journal Title

      Molecular Medicine Reports 1

      Pages: 869-874

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of TGF-beta signaling and regulatory and effector Tcell function in virus-induced neuroinflammatory disease2008

    • Author(s)
      Grant C., et. al.
    • Journal Title

      Blood Mar 7(Epub)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease2008

    • Author(s)
      Grant C., et. al.
    • Journal Title

      Blood Mar 7(Epub)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] HAMにおけるウイルス感染CD4+CD25+CCR4+FoxP3^<low>T細胞の増加と機能異常2009

    • Author(s)
      山野嘉久、他
    • Organizer
      第21回日本神経免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-13
    • Related Report
      2008 Final Research Report
  • [Presentation] HAMにおけるウイルス感染CD4+CD25+CCR4+FoxP3^<low> T細胞の増加と機能異常2009

    • Author(s)
      山野嘉久, 他
    • Organizer
      第21回日本神経免疫学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] IFN-γproducing CD4+CD25+CCR4+FoxP3^<low> T cells are increased and correlated with disease severity in HTLV-I associated neuroimunological disease2008

    • Author(s)
      山野嘉久、他
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Deficiency of innate immunity in HTLV-1 associated neuroimmunological disorder2008

    • Author(s)
      阿座上和子、山野嘉久他
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)患者におけるIFN-γ産生CD4+CD25+CCR4+FoxP3^<low>異常T細胞の増加2008

    • Author(s)
      山野嘉久、他
    • Organizer
      第1回HTLV-I研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-24
    • Related Report
      2008 Final Research Report
  • [Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性 : 免疫学的ATL危険因子とその回避2008

    • Author(s)
      神奈木真理、山野嘉久、他
    • Organizer
      第1回HTLV-I研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-24
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)における自然免疫系の異常2008

    • Author(s)
      佐藤知雄、山野嘉久、他
    • Organizer
      第12回日本神経ウイルス研究会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] HTLV-1 taxによるRhoGTPaseを介した細胞運動機能への作用2008

    • Author(s)
      新谷奈津美、山野嘉久、他
    • Organizer
      第12回日本神経ウイルス研究会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-07-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 全身性筋緊張性疼痛症候群 : 線維筋痛症から見出された新しい疾患概念2008

    • Author(s)
      山野嘉久、他
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] HAM(HTLV-I関連脊髄症)におけるNKT細胞2008

    • Author(s)
      阿座上和子、山野嘉久、他
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Systemic Myotonic Pain Syndrome : A New Clinical Entity Found From Fibromyalgia2008

    • Author(s)
      Yamano Y., et.al
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatolog
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Increased Prevalence Of Group A b-hemolytic Streptococcus Among Ethnic Population In Kyrgyzstan Defined By Rapid Antigen Detection Test2008

    • Author(s)
      Omurzakova N.A., Yamano Y. et.al.
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatolog
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Detection of Immuno-Pathogenic T cells In HTLV-I Associated Neuroimunological Disease : Discovery of A New T Cell Population2008

    • Author(s)
      Yamano Y., et.al.
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatolog
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Deficiency of innate immunity in HTLV-1 associated neuroimmunological disease2008

    • Author(s)
      Azakami K., Yamano Y. et.al.
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatology
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)におけるNatural killer T(NKT)細胞および樹状細胞の異常2008

    • Author(s)
      佐藤知雄、山野嘉久、他
    • Organizer
      第1回HTLV-I研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)患者におけるCD4+CD25+FoxP3^<low>異常T細胞の増加2008

    • Author(s)
      山野嘉久、他
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] IFN-γ producing CD4+CD25+CCR4+FoxP3^<low> T cells are increased and correlated with disease severity in HTLV-I associated neuroimunological disease2008

    • Author(s)
      山野嘉久, 他
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Deficiency of innate immunity in HTLV-I associated neuroim munological disorder2008

    • Author(s)
      阿座上和子, 他
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)におけるNatural killer T (NKT)細胞および樹状細胞の異常2008

    • Author(s)
      佐藤知雄, 他
    • Organizer
      第1回 HTLV-I研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] HTLV-I関連脊髄症(HAM)患者におけるIFN-γ産生CD4+CD25+CCR4+FoxP3^<low>異常T細胞の増加2008

    • Author(s)
      山野嘉久, 他
    • Organizer
      第1回HTLV研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性 : 免疫学的ATL危険因子とその回避2008

    • Author(s)
      神奈木真理, 他
    • Organizer
      第1回HTLV研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] HTLV-I taxによるRhoGTPaseを介した細胞運動機能への作用2008

    • Author(s)
      新谷奈津美, 他
    • Organizer
      第12回日本神経ウイルス研究会学術集会
    • Place of Presentation
      鹿児島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Systemic Myotonic Pain Syndrome : A New Clinical Entity Found From Fibromyalgia.2008

    • Author(s)
      Yamano Y., et al
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatology.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Increased Prevalence Of Group A b-hemolytic Streptococcus Among Ethnic Population In Kyrgyzstan Defined By Rapid Antigen Detection Test.2008

    • Author(s)
      Omurzakova N. A., et al
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatology.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Detection of Immuno-Pathogenic T cells In HTLV-I Associated Neuroimunological Disease : Discovery of A New T Cell Population.2008

    • Author(s)
      Yamano Y., et al
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatology.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Deficiency of innate immunity in HTLV-I associated neuroimmunological disease.2008

    • Author(s)
      Azakami K., et al
    • Organizer
      13th Congress of the Asia Pacific League of association for Rheumatology.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 無症候性キャリアーにおけるT細胞の低応答性2007

    • Author(s)
      清水由紀子、山野嘉久、他
    • Organizer
      第55回日本ウイルス学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 線維筋痛症における筋不随意運動2007

    • Author(s)
      山野嘉久、他
    • Organizer
      第1回線維筋痛症研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-24
    • Related Report
      2008 Final Research Report
  • [Presentation] High expression of CD28 co-stimulatory molecules and low expression of CTLA-4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy(HAM/TSP)2007

    • Author(s)
      Yamano Y., et. al.
    • Organizer
      International conference on Human Retrovirology: HTLV-I and Related Viruses.
    • Place of Presentation
      Hakone, Japan
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] High expression of CD28 co-stimulatory molecules and low expression of CTLA-4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy (HAM/TSP)2007

    • Author(s)
      Yamano Y., et.al.
    • Organizer
      The 13^<th> International conference on Human Retrovirology : HTLV-I and RelatedViruses
    • Place of Presentation
      箱根
    • Year and Date
      2007-05-23
    • Related Report
      2008 Final Research Report
  • [Book] HTLV-1のこと「HTLV-1ウイルスと免疫の関係」2008

    • Author(s)
      菅付加代子、他
    • Publisher
      特定非営利活動法人日本からHTLVウイルスをなくす会、教えて!
    • Related Report
      2008 Final Research Report
  • [Book] 世界の発酵乳「現代キルギスの健康問題の一側面」2008

    • Author(s)
      石毛直道編
    • Publisher
      はる書房
    • Related Report
      2008 Final Research Report
  • [Remarks] 山野嘉久、「HAMの最前線」HAM患者会全国大会にて講演2008年4月20日、横浜

    • Related Report
      2008 Final Research Report
  • [Remarks] HAM患者会「アトムの会」関東支部顧問

    • Related Report
      2008 Final Research Report
  • [Remarks] NPO法人「日本からHTLV-1ウイルスをなくす会」顧問

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] HTLV-I関連脊髄症を治療または予防するための医薬、およびHTLV-I関連脊髄症の患者に対する抗体療法の効果を予測する方法2008

    • Inventor(s)
      山野嘉久、新谷奈津美
    • Industrial Property Rights Holder
      聖マリアンナ医科大学
    • Industrial Property Number
      2008-027451
    • Filing Date
      2008-10-24
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患の病因細胞の分離方法および自己免疫疾患の診断補助方法2008

    • Inventor(s)
      山野嘉久
    • Industrial Property Rights Holder
      聖マリアンナ医科大学
    • Industrial Property Number
      2008-018058
    • Filing Date
      2008-07-10
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患の病因細胞の分離方法および自己免疫疾患の診断補助方法2008

    • Inventor(s)
      山野嘉久
    • Industrial Property Rights Holder
      聖マリアンナ医科大学
    • Industrial Property Number
      2008-180580
    • Filing Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] HTLV-I関連脊髄症を治療または予防するための医薬、およびHTLV-I関連脊髄症の患者に対する抗体療法の効果を予測する方法2008

    • Inventor(s)
      山野嘉久, 新谷奈津美
    • Industrial Property Rights Holder
      聖マリアンナ医科大学
    • Industrial Property Number
      2008-274514
    • Filing Date
      2008-10-24
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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