Anovel therapeutic approach to central nervous system demyelinating disease with anti-piatelet agents

• Project/Area Number: 19591018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kinki University
• Principal Investigator: MIYAMOTO Katsuichi Kinki University, 医学部, 講師 (50388526)
• Co-Investigator(Kenkyū-buntansha): KUSUNOKI Susumu 近畿大学, 医学部, 教授 (90195438)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経内科 / 神経免疫 / 脳・神経 / 中枢神経 / 多発性硬化症 / 実験的自己免疫性脳脊髄炎 / 抗血小板薬 / 接着分子

Research Abstract

抗血小板薬であるCilostazolが多発性硬化症の動物モデルである実験的自己免疫性脳脊髄炎(EAE)の治療に有効であることを見出した。MOG誘導マウスEAEにCilostazol含有エサを継続投与するとEAE症状は有意に軽症化した。MOG反応性T細胞のrecall responseはCilostazol投与群では増殖反応やIFNγ産生が抑制され、血清中の可溶性接着分子であるICAM-1やp-selectinが有意に低下した。以上より、Cilostazolは自己反応性T細胞増殖や接着分子の発現を抑制することによりEAEに対する治療効果を有する。

Research Products

• [Journal Article] Selective phosphodiesterase-3 inhibitor cilostazol ameliorates experimental autoimmune encephalomyelitis (2009)
  • Author(s): Miyamoto K, 他4名, Kusunoki S, 他4名
  • Journal Title: Neuroreport (印刷中)
  • Peer Reviewed
• [Journal Article] Upregulation of water channel aquaporin-4 in experimental autoimmune encephalomyeritis (2009)
  • Author(s): MiyamotoK, 他5名, Kusunoki S, 他5名
  • Journal Title: J Neurol Sci. 276巻 Pages: 103-107
  • Peer Reviewed
• [Journal Article] Selective phosphodiesterase-3 inhibitor cilostazol has repressive effects on experimental autoimmune encephalomyelitis (2009)
  • Author(s): Miyamoto K, et al.
  • Journal Title: NeuroReport (印刷中)
  • Peer Reviewed
• [Journal Article] Roles of complex gangliosides in the development of experimental autoimmune encephalomyelitis (2008)
  • Author(s): Miyamoto K, 他5名, Kusunoki S, 他5名
  • Journal Title: Glycobiology 18巻 Pages: 408-413
  • Peer Reviewed
• [Journal Article] Selective phosphodiesterase-3 inhibitor cilostazol has repressive effects on experimental autoimmune encephalomyelitis (2008)
  • Author(s): Kureshiro J
  • Journal Title: Experimental Neurology (In press)
  • Peer Reviewed
• [Presentation] The treatment with selective phosphodiesterase-3 inhibitor cilostazol for experimental autoimmune encephalomyelitis (2008)
  • Author(s): Miyamoto K, 他3名
  • Organizer: 国際神経免疫学会(ICN 2008)
  • Place of Presentation: 米国テキサス
  • Year and Date: 2008-10-29
• [Presentation] The treatment with selective phosphodiesterase-3 inhibitor cilostazol for experimental autoimmune encephalomyelitis (2008)
  • Author(s): Miyamoto K, et al.
  • Organizer: 国際神経免疫学会(ICN 2008)
  • Place of Presentation: 米国・テキサス
  • Year and Date: 2008-10-29
• [Presentation] 実験的自己免疫性脳脊髄炎に対するcilostazolの治療効果 (2008)
  • Author(s): 宮本勝一, ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] Selective phosphodiesterase-3 inhibitor cilostazol has repressive effects oon experimental autoimmune encephalomyelitis (2007)
  • Author(s): Miyamoto K
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Selective phosphodiesterase-3 inhibitor cilostazol has repressive effects on experimental autoimmune encephalomyelitis (2007)
  • Author(s): 宮本勝一, 他2名
  • Organizer: 第37回日本免疫学会総会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2007-11-20
• [Presentation] 抗血小板薬を用いた実験的自己免疫性脳脊髄炎の治療 (2007)
  • Author(s): 宮本勝一, 他3名
  • Organizer: 第25回日本神経治療学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-21
• [Book] 【多発性硬化症の診断と治療】多発性硬化症の新薬開発の現状 : 世界の動向と日本 (2008)
  • Author(s): 宮本勝一
  • Publisher: 新興医学出版社