Study on insulinoropic mechanisms co-operated by GLP-1 and GIP

• Project/Area Number: 19591032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Akita University
• Principal Investigator: YAMADA Yuichiro Akita University, 医学部, 教授 (60283610)
• Co-Investigator(Renkei-kenkyūsha): NARITA Takuma 秋田大学, 医学部, 准教授 (70282168)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 糖尿病 / シグナル伝達 / インクレチン

Research Abstract

インクレチンであるGLP-1とGIPはインスリン分泌促進の点では、いずれも膵β細胞に協調的に作用する。骨の代謝では、GIP は骨芽細胞、GLP-1 は甲状腺C 細胞に作用と、標的細胞は違うが、いずれも骨の強化に繋がる。しかしながら、体重に関しては全く逆の作用を示す。α-グルコシダーゼ阻害薬はGLP-1 やGIP の分泌動態を変えることを考えあわせると、インクレチンの生理作用の統合的な理解がインクレチン薬の理解に繋がる。

Research Products

• [Journal Article] Miglitol induces prolonged and enhanced glucagon-like peptide-1 and reduced gastric inhibitory polypeptide responses after ingestion of a mixed meal in Japanese type 2 diabetic patients (2009)
  • Author(s): Narita T, Katsuura Y, Sato T, Hosoba M, Fujita H, Morii T, Yamada Y
  • Journal Title: Diabet Med 26(2) Pages: 187-8
  • Peer Reviewed
• [Journal Article] Miglitol induces prolonged and enhanced glucagon-like peptide-1 and reduced gastric inhibitory polypeptide responses after ingestion of a mixed meal in Japanese type 2 diabetic patients (2009)
  • Author(s): Narita T
  • Journal Title: Diabetic Medicine 26 Pages: 187-188
  • Peer Reviewed
• [Journal Article] Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice (2008)
  • Author(s): Naitoh R, Miyawaki K, Harada N, Mizunoya W, Toyoda K, Fushiki T, Yamada Y, Seino Y, Inagaki N
  • Journal Title: Biochem Biophys Res Commun 376(1) Pages: 21-5
  • Peer Reviewed
• [Journal Article] The murine glucagon-like peptide-1 receptor is essential for control of bone resorption (2008)
  • Author(s): Yamada C, Yamada Y, Tsukiyama K, Yamada K, Udagawa N, Takahashi N, Tanaka K, Drucker DJ, Seino Y, Inagaki N
  • Journal Title: Endocrinology 149(2) Pages: 574-9
  • Peer Reviewed
• [Journal Article] Glycemic instability in type1 diabetic patients : Possible role of ketosis or ketoacidosis at onset of diabetes (2008)
  • Author(s): Sassa M, Yamada Y, Hosokawa M, Fukuda K, Fujimoto S, Toyoda K, Tsukiyama K, Seino Y, Inagaki N
  • Journal Title: Diabetes Res Clin Pract 81(2) Pages: 190-5
  • Peer Reviewed
• [Journal Article] Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells (2008)
  • Author(s): Watanabe R, Shen ZP, Tsuda K, Yamada Y
  • Journal Title: Biochem Biophys Res Commun 377(3) Pages: 867-72
  • Peer Reviewed
• [Journal Article] A novel gastric inhibitory polypeptide (GIP) receptor splice variant influences GIP sensitivity of pancreatic β-cells in obese mice (2008)
  • Author(s): Harada N, Yamada Y, Tsukiyama K, Yamada C, Nakamura Y, Mukai E, Hamasaki A, Liu X, Yamada K, Sasaki M, Toyoda K, Seino Y, Inagaki N
  • Journal Title: Am J Physiology Endocrinol Metab 294(1)
  • Peer Reviewed
• [Journal Article] Insulin gene is a target in activin receptor-like kinase 7 signaling path way in pancreatic beta-cells (2008)
  • Author(s): Watanabe R
  • Journal Title: Biochem Biophys Res Commun 377 Pages: 867-872
  • Peer Reviewed
• [Journal Article] Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice (2008)
  • Author(s): Naitoh R
  • Journal Title: Biochem Biophys Res Commun 376 Pages: 21-25
  • Peer Reviewed
• [Journal Article] The murine glucagon-like peptide-1 receptor is essential for control of bone resorption. (2008)
  • Author(s): Chizumi Yamada
  • Journal Title: Endocrinology 149 Pages: 574-579
  • Peer Reviewed
• [Journal Article] A novel gastric inhibitory polypeptide (GIP) receptor splice variant in fluences GIP sensitivity of pancreatic β-cells in obese mice. (2008)
  • Author(s): Norio Harada
  • Journal Title: Am J Physiology Endocrinol Metab 294
  • Peer Reviewed
• [Journal Article] Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes (2007)
  • Author(s): Yamada C, Tsukiyama K, Yamada K, Yamane S, Harada N, Miyawaki K, Seino Y, Inagaki N, Yamada Y
  • Journal Title: Biochem Biophys Res Commun 364(1) Pages: 175-80
  • Peer Reviewed
• [Journal Article] Effects of long-term pravastatin treatment on serum and urinary monocyte chemoattractant protein-1 levels and renal function in type 2 diabetic patients with normoalbuminuria (2007)
  • Author(s): Fujita H, Koshimura J, Sato T, Miura T, Sasaki H, Morii T, Narita T, Kakei M, Ito S, Yamada Y
  • Journal Title: Ren Fail 29(7) Pages: 791-6
  • Peer Reviewed
• [Journal Article] Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice (2007)
  • Author(s): Fujita H, Kakei M, Fujishima H, Morii T, Yamada Y, Qi Z, Breyer MD
  • Journal Title: Biochem Biophys Res Commun 363(1) Pages: 37-43
  • Peer Reviewed
• [Journal Article] Clock Gene Defect Disrupts Light-Dependency of Autonomic Nerve Activity (2007)
  • Author(s): Ikeda H, Yong Q, Kurose T, Todo T, Mizunoya W, Fushiki T, Seino Y, Yamada Y
  • Journal Title: Biochem Biophys Res Commun 364(3) Pages: 457-63
  • Peer Reviewed
• [Journal Article] Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. (2007)
  • Author(s): Chizumi Yamada
  • Journal Title: Biochem Biophys Res Commun 364 Pages: 175-180
  • Peer Reviewed
• [Presentation] α-glucosidase inhibitor (miglitol) induces prolonged and enhanced GLP-1 and reduced GIP responses after ingestion of mixed meals in Japanese type-2 diabetic patients (2008)
  • Author(s): Narita T
  • Organizer: 68th Scientific Sessions American Diabetes Association
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 2008-06-08
• [Presentation] α-glucosidase inhibitor 8miglitol) induces prolonged and enhanced GLP-1 and reduced GIP responses after ingestion of mixed meals in Javanese type-2 diabetic patients (2008)
  • Author(s): Narita T
  • Organizer: 68th Scientific Sessions American Diabetes Association
  • Place of Presentation: 米国サンフランシスコ市
  • Year and Date: 2008-06-08
• [Presentation] GIPシグナルの遮断は加齢に伴う耐糖能障害を改善する (2008)
  • Author(s): 山田千積
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-26
• [Presentation] 消化管ホルモンGIPによる肝臓の糖代謝調節機構の検討 (2008)
  • Author(s): 山田耕太郎
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-26
• [Presentation] インスリン分泌指標SUITはインスリン治療必要性の鑑別に有用である (2008)
  • Author(s): 山田麻里子
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-26
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~rounen/achievement.html
• [Remarks]
  • URL: http://www.med.akita-u.ae.jp/~rounen/achievement.html
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~rounen/achievement.html