The roles of insulin receptor substrate-2 in the regulation of glucosehomeostasis and atherosclerosis

• Project/Area Number: 19591037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: KUBOTA Naoto The University of Tokyo, 医学部・附属病院, 特任准教授 (50396719)
• Co-Investigator(Kenkyū-buntansha): 山内 敏正 東京大学, 医学部附属病院, 特任准教授 (40372370) ; 植木 浩二郎 東京大学, 医学部附属病院, 准教授 (00396714) ; 門脇 孝 東京大学, 医学部附属病院, 教授 (30185889)
• Co-Investigator(Renkei-kenkyūsha): KADOWAKI Takashi 東京大学, 医学部・附属病院, 教授 (30185889) ; UEKI Kojiro 東京大学, 医学部・附属病院, 准教授 (00396714) ; YAMAUCHI Toshimasa 東京大学, 医学部・附属病院, 特任准教授 (40372370)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: インスリン受容体基質-2 / 血管内皮細胞 / 糖代謝 / 動脈硬化症

Research Abstract

2007年度に、血管内皮細胞において主要なIRS であるIRS-2 に着目し、インスリン抵抗性と血管内皮機能について、血管内皮細胞特異的IRS-2欠損マウス(ETIRS2KO マウス)を用いて検討を行った。その結果、血管内皮細胞におけるIRS-2欠損により血管内皮機能が低下し、インスリンによる骨格筋血流の増加や骨格筋間質へのインスリン移行の増加が障害され、その結果インスリン抵抗性を惹起した可能性が示唆された。そこで2008年度は、血管内皮機能改善薬をETIRS2KO マウスに投与し、骨格筋のインスリン抵抗性が改善するかどうかについて検討したところ、血管内皮機能改善薬の投与によりETIRS2KO では骨格筋血流や骨格筋間質のインスリン濃度の回復が認められ、骨格筋のインスリン抵抗性が改善した。

Research Products

• [Journal Article] a2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise. (2009)
  • Author(s): Miura S,Kai Y,Kamei Y,Bruce CR, Kubota N, Febbraio MA,Kadowaki T, Ezaki O
  • Journal Title: Am J Physiol Endocrinol Metab. 296
  • Peer Reviewed
• [Journal Article] Rimonabant ameliorates insulin resistance vla both adiponectin-dependent and adiponectin-independent pathways. (2009)
  • Author(s): Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Yamauchi T, Noda T,Nagai R, Tcrauchi Y, Tobe K, Ueki K, Kadowaki T
  • Journal Title: J. Biol. Chem 284 Pages: 1803-1812
  • Peer Reviewed
• [Journal Article] Crucial role ofinsulin receptor substrate-2 incompensatory beta-cell hyperplasia inresponse to high fat diet-inducedinsulin resistance (2008)
  • Author(s): Takamoto I, Terauchi Y, Kubota N, OhsugiM, Ueki K, Kadowaki T.
  • Journal Title: Diabetes Obes. Metab. S4 Pages: 147-156
• [Journal Article] AdiponectinSuppresses Colorectal Carcinogenesis under the High-fat Diet Condition (2008)
  • Author(s): Fujisawa T, Endo H, Tomimoto A, SugiyamaM, Takahashi H, Saito S, Inamori M,Nakajima N, Watanabe M, Kubota N,Yamauchi T, Kadowaki T, Wada K,Nakagama H, Nakajima A.
  • Journal Title: Gut 57 Pages: 1531-1538
• [Journal Article] TamaokiN, Nomura T, Kosaka K. An Efficient reproductive method for Irs2-/- micewith C57BL/6JJcl genetic background (2008)
  • Author(s): Hashimoto H, Eto T, Kamisako T, Hoya N,Hatakeyama T, Arai T, Yokosuka M,Ohnishi Y, Ito M, Hioki K, Suzuki R,Ohsugi M, Saito M, Ueyama Y, YamauchiT, Kubota N, Tobe K, Kadowaki T.
  • Journal Title: Exp. Anim. 57 Pages: 407-411
• [Journal Article] Yamauchi T, Tobe K, Kadowaki T, KosakaK. Fulminant type 1 diabetes mellitusobserved in insulin receptor substrate2 deficient mice. (2008)
  • Author(s): Arai T, Hashimoto H, Kawai K, Mori A,Ohnishi Y, Hioki K, Ito M, Saito M,Ueyama Y, Ohsugi M, Suzuki R, Kubota N.
  • Journal Title: Clin. Exp. Med. 8 Pages: 93-99
• [Journal Article] Dynamic functional relay between insulin receptorsubstrate 1 and 2 in hepatic insulinsignaling during fasting and feeding (2008)
  • Author(s): Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, OgataH, Tokuyama K, Ohsugi M, Sasako T, MoroiM, Sugi K, Kakuta S, Iwakura Y, Noda T,Ohnishi S, Nagai R, Tobe K, Terauchi Y,Ueki K, Kadowaki T.
  • Journal Title: Cell Metab. 8 Pages: 49-64
• [Journal Article] Impact of IncreasedPPARgamma Activity in Adipocytes invivo on Adiposity, Insulin Sensitivityand the Effects of RosiglitazoneTreatment (2008)
  • Author(s): Takasawa K, Kubota N, Terauchi Y, Kadowaki T.
  • Journal Title: Endocr. J 55 Pages: 767-776
• [Journal Article] Kadowaki T, Nagai R. SUMOylation ofKruppel-like transcription factor 5acts as a molecular switch intranscriptional programs of lipid metabolism involving PPAR-delta (2008)
  • Author(s): Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N.
  • Journal Title: Nat.Med. 14 Pages: 656-666
• [Journal Article] Molecular mechanismof moderate insulin resistance in adiponectin-knockout mice (2008)
  • Author(s): Yano W, Kubota N, Itoh S, Kubota T, Awazawa M, Moroi M, Sugi K, Takamoto I, Ogata H, Tokuyama K, Noda T, Terauchi Y, Ueki K, Kadowaki T.
  • Journal Title: Endocr. J. 55 Pages: 515-522
• [Journal Article] Peroxisomeproliferator-activated receptor gamma(PPARgamma) suppresses colonic epithelial cell turnover and coloncarcinogenesis through inhibition ofthe beta-catenin/T cell factor (TCF)pathway (2008)
  • Author(s): Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A,Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS
  • Journal Title: J. Pharmacol. Sci. 106 Pages: 627-638
• [Journal Article] Adiponectin induces insulinsecretion in vitro and in vivo at a lowglucose concentration. (2008)
  • Author(s): Okamoto M, Ohara-Imaizumi M, Kubota N, Hashimoto S, Eto K, Kanno T, Kubota T,Wakui M, Nagai R, Noda M, Nagamatsu S,Kadowaki T
  • Journal Title: Diabetologia 51 Pages: 827-835
• [Journal Article] Thephysiological and pathophysiologicalrole of adiponectin and adiponectinreceptors in the peripheral tissues and CNS (2008)
  • Author(s): Kadowaki T, Yamauchi T, Kubota N.
  • Journal Title: FEBS Lett. 582 Pages: 74-80
• [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration. (2008)
  • Author(s): Okamoto M, Ohara-Imaizumi M, Kubota N, Hashimoto S, Eto K, Kanno T, Kubota T, Wakui M, Nagai R, Noda M, Nagamatsu S, Kadowaki T
  • Journal Title: Diabetologia 51 Pages: 827-835
  • Peer Reviewed
• [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. (2008)
  • Author(s): Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R
  • Journal Title: Nat Med 14 Pages: 656-666
  • Peer Reviewed
• [Journal Article] Molecular Mechanism of Moderate Insulin Resistance in Adiponectin-Knockout Mice. (2008)
  • Author(s): Yano W, Kubota N, Itoh S, Kubota T, Awazawa M, Moroi M, Sugi K, Takamoto I, Ogata H, Tokuyama K, Noda T, Terauchi Y, Ueki K, Kadowaki T
  • Journal Title: Endocr J 55 Pages: 515-522
  • NAID: 10021266439
  • Peer Reviewed
• [Journal Article] Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insuin Signaling during Fasting and Feeding. (2008)
  • Author(s): Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Kadowaki T
  • Journal Title: Cell Metab 8 Pages: 49-64
  • Peer Reviewed
• [Journal Article] An Efficient reproductive method for Irs2-/- mice with C57BL /6 Jcl genetic background. (2008)
  • Author(s): Hashimoto H, Eto T, Kamisako T, Hoya N, Hatakeyama T, Arai T, Yokosuka M, Ohnishi Y, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Yamauchi T, Kubota N, Tobe K, Kadowaki T, Tamaoki N, Nomura T
  • Journal Title: Exp. Anim. 57 Pages: 407-411
  • Peer Reviewed
• [Journal Article] Impact of increased PPARγ; activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglita zone treatment. (2008)
  • Author(s): Takasawa K, Kubota N, Terauchi Y, Kadowaki T
  • Journal Title: Endocrine J 55 Pages: 767-776
  • Peer Reviewed
• [Journal Article] Crucial role of IRS-2 in compensatory B-cell hyperplasia in response to high-fat-diet-induced insulin resistance. (2008)
  • Author(s): Takamoto I, Terauchi Y, Kubota N, Kubota T. Ohsugi M, Ueki K, Kadowaki T
  • Journal Title: Diabetes, Obesity and Metabolism 10 Pages: 147-156
  • Peer Reviewed
• [Journal Article] Adiponectin Suppresses Colorectal Carcinogenesis under the High-fat Diet Condition. (2008)
  • Author(s): Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagame H, Nakajima A
  • Journal Title: Gut 57 Pages: 1531-1538
  • Peer Reviewed
• [Journal Article] The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. (2008)
  • Author(s): Kadowaki T, et. al.
  • Journal Title: FEBS Lett. 582 Pages: 74-80
  • Peer Reviewed
• [Journal Article] Role of alteredrenal lipid metabolism in thedevelopment of renal injury induced bya high-fat diet (2007)
  • Author(s): Kume S, Uzu T, Araki S, Sugimoto T,Isshiki K, Chin-Kanasaki M, Sakaguchi M,Kubota N, Terauchi Y, Kadowaki T, HanedaM, Kashiwagi A, Koya D
  • Journal Title: J. Am. Soc. Nephrol 18 Pages: 2715-2723
• [Journal Article] Adiponectin Stimulates AMP-ActivatedProtein Kinase in the Hypothalamus andIncreases Food Intake. (2007)
  • Author(s): Kubota N, Yano W, Kubota T, YamauchiT, Itoh S, Kumagai H, Kozono H, TakamotoI, Okamoto S, Shiuchi T, Suzuki R, SatohH, Tsuchida A, Moroi M, Sugi K, Noda T,Ebinuma H, Ueta Y, Kondo T, Araki E,Ezaki O, Nagai R, Tobe K, Terauchi Y,Ueki K, Minokoshi Y, Kadowaki T
  • Journal Title: Cell Metab 6 Pages: 55-68
• [Journal Article] Improved ELISA for selectivemeasurement of adiponectin multimersand identification of adiponectin inhuman cerebrospinal fluid. (2007)
  • Author(s): Ebinuma H, Miida T, Yamauchi T, HadaY, Hara K, Kubota N, Kadowaki T.
  • Journal Title: Clin. Chem 53 Pages: 1541-1544
• [Journal Article] Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake. (2007)
  • Author(s): Kubota N, et. al.
  • Journal Title: Cell Metab. 6 Pages: 55-68
  • Peer Reviewed
• [Journal Article] Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid. (2007)
  • Author(s): Ebinuma H, et. al.
  • Journal Title: Clin. Chem. 53 Pages: 1541-1544
  • Peer Reviewed
• [Journal Article] Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. (2007)
  • Author(s): Kume S, et. al.
  • Journal Title: J. Am. Soc. Nephrol. 18 Pages: 2715-2723
  • Peer Reviewed
• [Presentation] 血管内皮機能低下は骨格筋のインスリン抵抗性を惹起する (2009)
  • Author(s): 山口真一, 窪田直人, 他
  • Organizer: 第12回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-10
• [Presentation] 血管内皮細胞のインスリンシグナル障害は骨格筋インスリン抵抗性を引き起こす (2009)
  • Author(s): 窪田直人, 他
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] インスリン感受性調節における血管内皮細胞インスリンシグナルの役割 (2009)
  • Author(s): 窪田直人, 他
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 岡山国際交流会館
  • Year and Date: 2009-02-14
• [Presentation] 血管内皮細胞におけるインスリン受容体基質(IRS)2の役割の解明-血管内皮細胞特異的IRS2 欠損マウスを用いて- (2009)
  • Author(s): 窪田哲也, 窪田直人, 他
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 岡山国際交流会館
  • Year and Date: 2009-02-14
• [Presentation] インスリン感受性調節における血管内皮細胞インスリンシグナルの役割 (2009)
  • Author(s): 窪田直人,窪田哲也,山口真一,山内敏正,槙木浩二郎,門脇孝
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-02-13
• [Presentation] 血管内皮細胞におけるインスリン受容体基質(IRS)2の役割の解明-血管内皮細胞特異的IRS2欠損マウスを用いて- (2009)
  • Author(s): 窪田哲也,窪田直人,山口真一,井上真理子,植木浩二郎,門脇孝
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-02-13
• [Presentation] インスリン抵抗性とメタボリックシンドローム (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第6回徳島大学疾患酵素研究センターシンポジウム
  • Place of Presentation: 徳島大学
  • Year and Date: 2008-12-05
• [Presentation] インスリン抵抗性とメタボリックシンドローム (2008)
  • Author(s): 窪田直入,門脇孝
  • Organizer: 第6回徳島大学疾患酵素研究センターシンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 2008-12-05
• [Presentation] Insulinsignaling in endothelial cellsparticipates in the regulation ofskeletal muscle insulin sensitivity (2008)
  • Author(s): Kubota T, Kubota N, et al
  • Organizer: The 10th Symposium on MolecularDiabetology in Asia
  • Place of Presentation: 広州(中国)
  • Year and Date: 2008-11-29
• [Presentation] アディポカイン異常とメタボリックシンドローム (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第16回日本ステロイドホルモン学会学術集会
  • Place of Presentation: 福井
  • Year and Date: 2008-11-22
• [Presentation] Insulin signaling in endothelial cells participates in the regulation of skeletal muscle insulin sensitivity (2008)
  • Author(s): Kubota T, Kubota N, Yamaguchi S, Inoue M, Veki K, Kadowaki T
  • Organizer: The 10th Symposium on Molecular Diabetology in Asia
  • Place of Presentation: Guangzhou
  • Year and Date: 2008-10-29
• [Presentation] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding. (2008)
  • Author(s): Kubota N, Kubota T, Yamauchi T, Ueki K, Kadowaki T
  • Organizer: The 1st Insulin Resistance in Metabolic Disease Forum
  • Place of Presentation: Japan(Osaka)
  • Year and Date: 2008-09-20
• [Presentation] Dynamic functionalrelay between insulin receptorsubstrate-1 and -2 in hepatic insulinsignaling during fasting and feeding.The 4th Scientific Meeting of (2008)
  • Author(s): Kubota N, et.al.
  • Organizer: Asia-Pacific Diabetes and ObesityStudy Group
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-23
• [Presentation] 肝臓の糖代謝におけるIRS-1、IRS-2 の役割の検討 (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第13回アディポサイエンス研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-22
• [Presentation] 肝臓の糖代謝におけるIRS-1、IRS-2の役割の検討 (2008)
  • Author(s): 窪田直人,窪田哲也,伊藤晋介,山内敏正,植木浩二郎,門脇孝
  • Organizer: 第13回アディポサイエンス研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-22
• [Presentation] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding. (2008)
  • Author(s): Kubota N, Kubota T, Yamauchi T, Ueki K, Kadowaki T
  • Organizer: The 4th Scientific Meeting of Asia-Pacific Diabetes and Obesity Study Group
  • Place of Presentation: Japan(Osaka)
  • Year and Date: 2008-08-20
• [Presentation] Dynamic functionalrelay between insulin receptorsubstrate-1 and -2 in hepatic insulinsignaling during fasting and feeding. (2008)
  • Author(s): Kubota N, et.al.
  • Organizer: The 1st Insulin Resistance in MetabolicDisease Forum
  • Place of Presentation: 東京
  • Year and Date: 2008-07-26
• [Presentation] Insulin signaling defect in endothelial cells causesskeletal muscle insulin resistance (2008)
  • Author(s): Kubota N, Kubota T, Kumagai H, Yamauchi T, Ueki K, Kadowaki T
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 茨城
  • Year and Date: 2008-07-11
• [Presentation] Insulin signalingdefect in endothelial cells causesskeletal muscle insulin resistance (2008)
  • Author(s): Kubota N, et.al.
  • Organizer: 第40回日本動脈硬化学会総会・学術集 会
  • Place of Presentation: 茨城
  • Year and Date: 2008-07-10
• [Presentation] 血管内皮細胞におけるインスリン受容体基質(IRS)2の役割の解明 (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第1回日本肥満症治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-14
• [Presentation] Insulinsignaling in endothelial cellsparticipates in the regulation ofskeletal muscle insulin sensitivity (2008)
  • Author(s): Kubota T, Kubota N, et.al.
  • Organizer: 68th American Diabetes Association
  • Place of Presentation: サンフランシスコ(米国)
  • Year and Date: 2008-06-06
• [Presentation] Dynamic functionalrelay between insulin receptorsubstrate-1 and -2 in hepatic insulinsignaling during fasting and feeding (2008)
  • Author(s): Kubota N, et.al.
  • Organizer: 68th American Diabetes Association
  • Place of Presentation: サンフランシスコ(米国)
  • Year and Date: 2008-06-06
• [Presentation] Insulin signaling in endothelial cells participates in the regulation of skeletal muscle insulin sensitivity (2008)
  • Author(s): Kubota T, Kubota N, Kozono H, Takahashi T, Itoh S, Ueki K, Kadowaki T
  • Organizer: Scientific Sessions 68th American Diabetes Association
  • Place of Presentation: San Francisco
  • Year and Date: 2008-06-06
• [Presentation] Dynamic functional relay between insulin receptor substrate-1 and -2 in hepatic insulin signaling during fasting and feeding (2008)
  • Author(s): Kubota N, Kubota T, Itoh S Terauchi Y,Ueki K, Kadowaki T
  • Organizer: Scilentific Sessions 68th American Diabetes Association
  • Place of Presentation: San Frandisco
  • Year and Date: 2008-06-06
• [Presentation] インスリン抵抗性発症における血管と骨格筋のネットワーク機構の解明 (2008)
  • Author(s): 窪田哲也,, 窪田直人, 他
  • Organizer: 第51日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] アディポネクチンの摂食・エネルギー調節における役割 (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] チアゾリジン誘導体の抗動脈硬化作用におけるアディポネクチンの役割の解明 (2008)
  • Author(s): 高橋雄大, 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] アディポネクチン欠損マウスのインスリン抵抗性のメカニズムの解明 (2008)
  • Author(s): 伊藤晋介, 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 抗肥満薬Rimonabant におけるAdiponectin の役割 (2008)
  • Author(s): 渡辺拓, 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] IRS-2欠損膵ss細胞株の樹立 (2008)
  • Author(s): 高本偉碩, 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 血管内皮細胞におけるインスリン受容体基質(IRS)-2のインスリン分泌における役割の解析 (2008)
  • Author(s): 橋本信嗣, 窪田直人, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] インスリン抵抗性発症における血管と骨格筋のネットワーク機構の解明 (2008)
  • Author(s): 窪田哲也,窪田直人,熊谷洋紀,小園秀樹,高橋雄大,杉薫,山内敏正,植木浩二郎,門脇孝
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 抗肥満薬RimonabantにおけるAdiponectinの役割 (2008)
  • Author(s): 渡辺拓,窪田直人,窪田哲也,大杉満,戸辺一之,門脇孝
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] IRS-2欠損膵β細胞株の樹立 (2008)
  • Author(s): 高本偉碩,窪田直人,橋本信嗣,峯山智佳,窪田哲也,伊藤晋介,山内敏正,植木浩二郎,宮崎純一,門脇孝
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 肝臓特異的Irs2欠損マウスはインスリン抵抗性、耐糖能異常を呈する (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第22回日本糖尿病・肥満動物学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-09
• [Presentation] 肝臓特異的Irs2欠損マウスはインスリン抵抗性、耐糖能異常を呈する (2008)
  • Author(s): 窪田直人, 他
  • Organizer: 第22回日本糖尿病・肥満動物学会
  • Place of Presentation: 東京都品川区
• [Presentation] 発生工学の観点から-血管内皮特異的IRS2欠損マウスを用いた解析- (2007)
  • Author(s): 窪田直人, 他
  • Organizer: 第22回日本糖尿病合併症学会
  • Place of Presentation: 茨城
  • Year and Date: 2007-10-26
• [Presentation] アディポネクチンの中枢における役割の検討 (2007)
  • Author(s): 窪田直人, 他
  • Organizer: 第50回日本糖尿病学会年次学術
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25
• [Presentation] 発生工学の観点から-血管内皮特異的IRS2欠損マウスを用いた解析- (2007)
  • Author(s): 窪田直人, 他
  • Organizer: 第22回日本糖尿病合併症学会
  • Place of Presentation: 茨城県つくば市
• [Presentation] アディポネクチンの中枢における役割の検討 (2007)
  • Author(s): 窪田直人, 他
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 宮城県仙台市
• [Book] 細胞工学 (2008)
  • Author(s): 窪田直人, 他
  • Publisher: 秀潤社
• [Book] 細胞工学 (2007)
  • Author(s): 窪田直人, 他
  • Publisher: 秀潤社