Regression of Atherosclerosis by the regulation of nitric oxide and superoxide on vascular endocrinology and vascular aging

• Project/Area Number: 19591043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Nagoya University
• Principal Investigator: HAYASHI Toshio Nagoya University, 医学部附属病院, 講師 (80303634)
• Co-Investigator(Kenkyū-buntansha): UMEGAKI Hiroyuki 名古屋大学, 医学部附属病院, 助教 (40345898)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 一酸化窒素 / 動脈硬化症 / 細胞老化 / エストロゲン / 糖尿病 / 動脈硬化退縮 / 血管内皮細胞 / NOドナー

Research Abstract

高齢者を念頭にした老化血管における動脈硬化症退縮における血管老化制御の可能性を検討した.まず動脈硬化症への老化の関与及び一酸化窒素(NO)の老化に対する効果や冠危険因子との相互作用を検討した.次いで、老化に加えて高齢者に寄与の大きい動脈硬化危険因子としてエストロゲン(欠乏)、糖尿病、そして治療手段であり老化への直接作用もあるインスリンの老化及び血管機能への影響を検討した.

Research Products

• [Journal Article] and on behalf of Japan CDM group Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk for atherosclerotic diseases at various ages (2009)
  • Author(s): Hayashi T, Kawashima S, Itoh H, Yamada N, (他8名1番目)
  • Journal Title: Diabetes Care (in press)
• [Journal Article] Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk at various ages. (2009)
  • Author(s): Hayashi T, Kawashima S, Itoh H, (他9名1番目), on behalf of Japan CDM group.
  • Journal Title: Diabetes Care (印刷中)
  • Peer Reviewed
• [Journal Article] Nitric oxide and endothelial cellular senescence (2008)
  • Author(s): Hayashi T, Yano K, (他4名1番目)
  • Journal Title: Pharmacol Ther 120 Pages: 333-9
• [Journal Article] Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus (2008)
  • Author(s): Sasaki N, Yamashita T, Takaya T, Shinohara M, Fukatsu A, Hayashi T, (他6名6番目)
  • Journal Title: Arterioscler Thromb Vasc Biol 28 Pages: 1068-76
• [Journal Article] Pitavastatin Shows Promise in Treatment of Patients With Type 2 Diabetes (2008)
  • Author(s): Hayashi T, Iguchi A
  • Journal Title: Review of Endocrinology 1 Pages: 1-3
• [Journal Article] and on behalf of Japan CDM group Importance of Lipid Levels in Elderly Diabetic Individuals-Baseline Characteristics and 1-year Survey of Cardiovascular Events- (2008)
  • Author(s): Hayashi T, Kawashima S, (他10名1番目)
  • Journal Title: Circulation Journal 72 Pages: 218-225
• [Journal Article] Visceral fat contribution of insulin resistance in elderly people (2008)
  • Author(s): Umegaki H, Haimoto H, Kario K
  • Journal Title: J Am Geriatr Soc. 56 Pages: 1375-5
• [Journal Article] Volkow ND. D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats (2008)
  • Author(s): Thanos PK, Michaelides M, Umegaki H
  • Journal Title: Synapse 62 Pages: 481-6
• [Journal Article] Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice (2008)
  • Author(s): Umegaki H, Itoh A, Suzuki Y, Nabeshima T
  • Journal Title: Int Psychogeriatr 20 Pages: 800-6
• [Journal Article] Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly (2008)
  • Author(s): Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T
  • Journal Title: Age Ageing 37 Pages: 458-61
• [Journal Article] Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats (2008)
  • Author(s): Zhu W, Zhang R, Hu C, Umegaki H
  • Journal Title: Neuro Endocrinol Lett 29 Pages: 159-62
• [Journal Article] Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes : a 2-year follow-up study (2008)
  • Author(s): Haimoto H, Iwata M, Wakai K, Umegaki H
  • Journal Title: Diabetes Res Clin Pract 79 Pages: 350-6
• [Journal Article] Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients (2008)
  • Author(s): Umegaki H, Iimuro S (他6名, 1番目)
  • Journal Title: Neurobiol Aging 29 Pages: 1022-6
• [Journal Article] Importance of Lipid Levels in Elderly Diabetic Individuals-Baseline Characteristics and 1-year Survey of Cardiovascular Events - (2008)
  • Author(s): Hayashi T, Kawashima S, Itoh H, (他9名1番目), on behalf of Japan CDM group
  • Journal Title: Circulation Journal 72 Pages: 208-225
  • NAID: 110006571047
  • Peer Reviewed
• [Journal Article] Nitric oxide and endothelial cellular senescence (2008)
  • Author(s): Havashi T, Yano K, (他4名1番目)
  • Journal Title: Pharmacol Ther 120 Pages: 333-339
  • Peer Reviewed
• [Journal Article] Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus. (2008)
  • Author(s): Sasaki N, Yamashita T, Takaya T, Shinohara M, Fukatsu A, Hayashi T, (他4名6番目)
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology 28 Pages: 1068-1076
  • Peer Reviewed
• [Journal Article] Pitavastatin Shows Promise in Treatment of Patients With Type 2 Diabetes (2008)
  • Author(s): Hayashi T, Yokote K, Saito Y, Iguchi A.
  • Journal Title: Review of Endocrinology 1 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Visceral fat contribution of insulin resistance in elderly people. (2008)
  • Author(s): Umegaki H, Haimoto H, Kario K.
  • Journal Title: J Am Geriatr Soc 56 Pages: 1373-1375
  • Peer Reviewed
• [Journal Article] D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. (2008)
  • Author(s): Thanos PK, Michaelides M, Umegak H, Volkow ND.
  • Journal Title: Synapse 62 Pages: 481-486
  • Peer Reviewed
• [Journal Article] Glucose controllevels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysiunction in diabetic elderly. (2008)
  • Author(s): Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T.
  • Journal Title: Age Ageing 37 Pages: 458-461
  • Peer Reviewed
• [Journal Article] Effect of the entorhinal cortex on diumal ACTH and coiticosterone release in rats. (2008)
  • Author(s): Zhu W, Zhang R, Hu C, Umegaki H.
  • Journal Title: Neuro Endocrinol Lett. 29 Pages: 159-162
  • Peer Reviewed
• [Journal Article] Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients. (2008)
  • Author(s): Umegaki H, Iimuro S, (他6名1番目).
  • Journal Title: Neurobiol Aging 29 Pages: 1022-10026
  • Peer Reviewed
• [Journal Article] Importance of Lipid Levels in Elderly Diabetic Individuals-Baseline Characteristics and l-year Survey of Cardiovascular Events- (2008)
  • Author(s): Hayashi T,
  • Journal Title: Circulation Joumal 72 Pages: 208-225
  • Peer Reviewed
• [Journal Article] Nitric oxide (NO) metabolites are associated with survival in older patients (2007)
  • Author(s): Hayashi T, Nomura H, Osawa M, Funami J, Miyazaki A, Iguchi A
  • Journal Title: J Am Geriatr Soc 55 Pages: 1398-403
• [Journal Article] Alp NJ, Channon KM, Yokoyama M, Kawashima S. A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression (2007)
  • Author(s): Takaya T, Hirata KI, Yamashita T, Shinohara M, Sasaki N, Hayashi T, (他10名,6番目)
  • Journal Title: Arterioscler Thromb Vasc Biol 27 Pages: 1632-1637
• [Journal Article] Efficacy and Safety Expert of Opinion on Pharmacology (2007)
  • Author(s): Hayashi T, Yokote K, Saito Y, Iguchi A
  • Journal Title: Pitavastatin 8 Pages: 2315-27
• [Journal Article] Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly post menopausal women (2007)
  • Author(s): Ding Qungfang, *Hayashi T, (他5名, 2番目)
  • Journal Title: JDiabetes and its Complication 21 Pages: 315-9
• [Journal Article] Possible Usefulness of Apocynin, an NADPH Oxidase Inhibitor, for Nitrate Tolerance : Prevention from Nitric Oxide Donor-Induced Endothelial Cell Abnormalities (2007)
  • Author(s): Fukatsu A, Hayashi T, (他6名, 2番目)
  • Journal Title: Am J Physiol Heart Circ Physiol 293 Pages: 790-7
• [Journal Article] High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase : implications for atherosclerosis (2007)
  • Author(s): Hayashi T, Juliet PA, Miyazaki A, Ignarro LJ, Iguchi A
  • Journal Title: Biochim Biophys Acta 1772 Pages: 364-72
• [Journal Article] beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes (2007)
  • Author(s): Hayashi T, (他6名, 1番目)
  • Journal Title: Life Sci 80 Pages: 592-9
• [Journal Article] 17beta-estradiol antagonizes the down- regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose : relevance to postmenopausal diabetic cardiovascular disease (2007)
  • Author(s): Miyazaki-Akita A, Hayashi T, (他5名, 2番目)
  • Journal Title: J Pharmacol Exp Ther 320 Pages: 591-8
• [Journal Article] Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin (2007)
  • Author(s): Osawa M, Hayashi T. (他5名2番目)
  • Journal Title: Nitric Oxide 16 Pages: 157-63
• [Journal Article] Attitudes toward disclosing the diagnosis of dementia in Japan (2007)
  • Author(s): Umegaki H, Onishi J, Suzuki Y, Endo H, Iguchi A
  • Journal Title: Int Psychogeriatr 19 Pages: 253-65
• [Journal Article] Which two questions of Mini-Mental State Examination (MMSE) should we start from (2007)
  • Author(s): Onishi J, Suzuki Y, Umegaki H, Kawamura T, Imaizumi M, Iguchi A
  • Journal Title: Arch Gerontol Geriatr 44 Pages: 43-8
• [Journal Article] Nitric oxide (NO) metabolites are associated with survival in older patients. (2007)
  • Author(s): Hayashi T,
  • Journal Title: J American Geriatric Society 55 Pages: 1398-403
  • Peer Reviewed
• [Journal Article] A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression. (2007)
  • Author(s): Takaya T,
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology (印刷中)
  • Peer Reviewed
• [Journal Article] Pitavastatin-Efficacy and Safety (invited review) (2007)
  • Author(s): Hayashi T,
  • Journal Title: Expert of Opinion on Pharmacology 8 Pages: 2315-27
  • Peer Reviewed
• [Journal Article] Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly post menopausal women (2007)
  • Author(s): Hayashi T,
  • Journal Title: J Diabetes and its Complication 21 Pages: 315-9
  • Peer Reviewed
• [Journal Article] Possible Usefulness of Apocynin, an NADPH Oxidase Inhibitor, for Nitrate Tolerance: Prevention from Nitric Oxide Donor-Induced Endothelial Cell Abnormalities. (2007)
  • Author(s): Hayashi T,
  • Journal Title: Am J Physiol Heat Circ Physiol. 293
  • Peer Reviewed
• [Journal Article] High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis. (2007)
  • Author(s): Hayashi T,
  • Journal Title: Biochim Biophys Acta 1772 Pages: 364-72
  • Peer Reviewed
• [Journal Article] betal antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes. (2007)
  • Author(s): Hayashi T
  • Journal Title: Life Sci. 80 Pages: 592-9
  • Peer Reviewed
• [Journal Article] 17beta-estiadiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. (2007)
  • Author(s): Hayashi T,
  • Journal Title: J Pharmacol Exp Ther 320 Pages: 591-8
  • Peer Reviewed
• [Journal Article] Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin. (2007)
  • Author(s): Hayashi T,
  • Journal Title: Nitric Oxide 16 Pages: 157-63
  • Peer Reviewed
• [Presentation] Low HDL- cholesterol is associated with the risk of stroke in elderly diabetic individuals : Changes in the risk for atherosclerotic diseases at various ages (2009)
  • Author(s): Hayashi T. (他10名1番目)
  • Organizer: American Diabetes Association
  • Place of Presentation: New Orleans USA
  • Year and Date: 2009-06-06
• [Presentation] The role of glucose and insulin on endothelial senescence- The relation of diversity effect of insulin and telomerase- (2009)
  • Author(s): Hayashi T. (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-04-29
• [Presentation] Vascular senescence and NO in asian elderly (2008)
  • Author(s): Hayashi T
  • Organizer: Invited speech at Symposium of Konkuk University
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-17
• [Presentation] Vascular senescence and NO inasian elderly. (2008)
  • Author(s): Hayashi T
  • Organizer: Symposium of Konkuk University
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-17
• [Presentation] siRNAを用いた老化関連疾患の病態解明 (2008)
  • Author(s): 林登志雄
  • Organizer: 薬物活性シンポジウムRNA干渉
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-23
• [Presentation] "Health of Chinese elderly female" Approach for the Healthy Longevity in Asia (2008)
  • Author(s): Zhang J, Hayashi T
  • Organizer: 5th Asia/Oceania Geriatric and Gerontology International Meeting Symposium "Approach for the Healthy Longevity in Asia"
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-10-23
• [Presentation] The Healthy Longevity in Japan (2008)
  • Author(s): Hayashi T
  • Organizer: 5th Asia/Oceania Geriatric and Gerontology International Meeting Symposium "Approach for the Healthy Longevity in Asia"
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-10-23
• [Presentation] Metabolic syndrome and Diabetes in Chinese elderly female (2008)
  • Author(s): Ding Qung-Fan D, Hayashi T
  • Organizer: 5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-10-20
• [Presentation] Pathophysiological Character of metabolic syndrome in Asian elderly female (2008)
  • Author(s): Funami J, Hayashi T
  • Organizer: 5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-10-20
• [Presentation] Metabolic syndrome in Japan, Future attitude as Asian geriatricians (2008)
  • Author(s): Hayashi T
  • Organizer: 5^<th>Asia/Oceania Geriatric and Gerontology International Meeting Symposium "The Health in Asian elderly female"
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-10-20
• [Presentation] siRNAを用いた老化関連疾患の病態解明〜RNA干渉 (2008)
  • Author(s): 林登志雄
  • Organizer: 第38回 薬物活性シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] HDL cholesterol is more important than glucose control in prevention of athero- sclerotic diseases in Asian diabetic elderly (2008)
  • Author(s): Hayashi T
  • Organizer: Symposium 5th Congress of European Union Geriatric Medicine Society
  • Place of Presentation: Copenhagen, Denmark (press release)
  • Year and Date: 2008-09-05
• [Presentation] HDL cholesterol is more important than glucose control in prevention of atherosclerotic diseases in Asian diabetic elderly. (2008)
  • Author(s): Hayashi T
  • Organizer: Symposiurn 5th Congress of European Union Geriatric Medicine Society
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2008-09-05
• [Presentation] インスリンの細胞老化ストレスを介する動脈硬化への作用 Insulin exerts opposite control on high glucose-induced endothelial cellular senescence (2008)
  • Author(s): 林登志雄
  • Organizer: 第40回に本動脈硬化学会シンポジウム「細胞ストレスと動脈硬化」
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-15
• [Presentation] インスリンの細胞老化ストレスを介する動脈硬化への作用 (2008)
  • Author(s): 林登志雄
  • Organizer: 第40回日本動脈硬化学会シンポジウム
  • Place of Presentation: 筑波
  • Year and Date: 2008-07-13
• [Presentation] 各種高脂血症薬の糖尿病性心血管合併症進展予防効果の総合的検討-二年間の解析より- (2008)
  • Author(s): 林登志雄, 伊奈孝一郎, 井口昭久
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 動脈硬化症における加齢と性の役割-本邦閉経後女性の心血管病リスクの面から- (2008)
  • Author(s): 林登志雄
  • Organizer: 第8回日本抗加齢医学会パドルセッション : 女性ホルモン補充療法をめぐる議論(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2008-05-14
• [Presentation] 動脈硬化症における加齢と性の役割-本邦閉経後女性の心血管病リスクの面から- (2008)
  • Author(s): 林登志雄
  • Organizer: 第8回日本抗加齢医学会バトルセッション : 女性ホルモン補充療法をめぐる議論(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2008-05-09
• [Presentation] アジア地区高齢女性における動脈硬化性疾患と遺伝子変異に関する検討 (2008)
  • Author(s): 伊奈孝一郎, 林登志雄, 平井寿子, F. J., 井口昭久
  • Organizer: 第8回日本NO学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-08
• [Presentation] LDL and HDL cholesterol might play morei mportant role than glucose control in the prevention of ischemic cardiovascular disease in Japanese diabetic old and old. (2008)
  • Author(s): Hayashi T, (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-05-02
• [Presentation] The effect of NO in endothelial senescence. (2008)
  • Author(s): Hayashi T, (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-05-02
• [Presentation] LDL and HDL cholesterol might play more important role than glucose control in the prevention of ischemic cardiovascular disease in Japanese diabetic old and old (2008)
  • Author(s): Hayashi T (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Washington USA
  • Year and Date: 2008-05-01
• [Presentation] The effect of NO in endothelial senescence (2008)
  • Author(s): Hayashi T (他3名1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Washington USA
  • Year and Date: 2008-05-01
• [Presentation] Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance : prevention of NO donor-induced endothelial cell abnormalities (2008)
  • Author(s): Hayashi T (他3名1番目)
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-23
• [Presentation] Nitric Oxide Metabolites Are Associated with Survival in Older Patients (2008)
  • Author(s): Hayashi T (他3名1番目)
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-23
• [Presentation] Nitric oxide and endothelial cell senescence (2007)
  • Author(s): Hayashi T
  • Organizer: AVDRC Symposium on vascular aging and atherosclerosis (Invited special lecture)
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2007-11-16
• [Presentation] グルコース:負荷内皮細胞老化と内皮機能-糖尿病性血管合併症での意義 (2007)
  • Author(s): 林登志雄
  • Organizer: 第11回日本心血管内分泌代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-16
• [Presentation] Nitric oxide and endothelial cell senescenoe (2007)
  • Author(s): T. Hayashi
  • Organizer: AVDRC Symposium on "Vascular Aging and Atherosclerosis" (Invited Special Lecture)
  • Place of Presentation: Daegu, South Korea
  • Year and Date: 2007-11-16
• [Presentation] (1)Endocrinological Biomarker Representing the Risk of Metadolic Syndrome, Diabetes and Hyperlipidemia in Japan, Future Attitude as Asian Geriatrics (2)The Healthy Longevity in Japan (2007)
  • Author(s): T. Hayashi
  • Organizer: The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics (Symposium)
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-10-23
• [Presentation] 各種高脂血症薬の糖尿病合併心血管病進展予防効果の検討-厳格な脂質及び糖代謝制御の必要性について- (2007)
  • Author(s): 林登志雄
  • Organizer: 第39回日本動脈硬化学会総会シンポジウム 糖尿病/耐糖能障害と動脈硬化
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-14
• [Presentation] 内皮細胞の老化はNOにより阻害される-閉経及び糖尿病に関連した動脈硬化症での意義 (2007)
  • Author(s): 林登志雄
  • Organizer: 第39回日本動脈硬化学会総会シンポジウム血管細胞老化と動脈硬化
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-14
• [Presentation] Endothelial sensescence is prevented by NO-The role in atherosclerosis- (2007)
  • Author(s): 林登志雄
  • Organizer: 第7回日本NO学会 シンポジウム
  • Place of Presentation: 大津
• [Presentation] 内皮細胞老化はNOで阻害されるー糖尿病性血管合併症での意義 (2007)
  • Author(s): 林登志雄(他2名1番目)
  • Organizer: 第50回日本糖尿病学会学術集会
  • Place of Presentation: 仙台
• [Presentation] 肥満・糖尿病における心血管障害の進展抑制-各種高脂血症薬、降圧薬の作用について- (2007)
  • Author(s): 林登志雄
  • Organizer: 第50回日本糖尿病学会学術集会 ランチョンセミナー
  • Place of Presentation: 仙台
• [Presentation] 内皮細胞老化はNOで阻害される-動脈硬化症での意義- (2007)
  • Author(s): 林登志雄(他2名1番目)
  • Organizer: 第49回日本老年医学会学術集会
  • Place of Presentation: 札幌
• [Presentation] グルコース負荷内皮細胞老化と内皮機能-糖尿病性血管合併症での意義 (2007)
  • Author(s): 林登志雄(他2名1番目)
  • Organizer: 第11回日本心血管内分泌代謝学会
  • Place of Presentation: 東京
• [Presentation] 内皮細胞はNOで阻害される -動脈硬化症での意義- (2007)
  • Author(s): 林登志雄
  • Organizer: 第49回日本老年医学会
  • Place of Presentation: 札幌
• [Presentation] 1)内皮細胞の老化はNOにより阻害されるー閉経及び糖尿病に関連した動脈硬化症での意義2)各種高脂血症薬の糖尿病合併心血管病進展予防効果の検討-厳格な脂質及び糖代謝制御の必要性について- (2007)
  • Author(s): 林登志雄
  • Organizer: 第37回日本動脈硬化学会学術集会(シンポジウム)
  • Place of Presentation: 大阪
• [Book] Free radicals as atherosclerotic risk-The relation of NO Louis J Ignarro NO 2^<nd> (2009)
  • Author(s): *Toshio Hayashi, Akihisa Iguchi
  • Publisher: Edition Elsevier
• [Book] Free radicals as atherosclerotic risk-The relation of NO (2009)
  • Author(s): Hayashi T
  • Publisher: Elsevier Co. Ltd(印刷中)
• [Book] 老化的自然科学他 (2008)
  • Author(s): 林登志雄
  • Publisher: 雲南出版集団公司、雲南人民出版社
• [Book] 現代老年学(これからの老年学 : 中国語版) (2008)
  • Author(s): 井口昭久/林登志雄/余沢雲
  • Publisher: 雲南出版集団公司、雲南人民出版社
• [Book] 尿失禁 (2008)
  • Author(s): 林登志雄
  • Publisher: 南山堂 東京
• [Patent(Industrial Property Rights)] シトルリンまたはその塩およびアルギニンまたはその塩を有効成分として含有する、即効性アルギニン血中濃度上昇型経口剤 (2008)
  • Inventor(s): 林登志雄 (他2名1番目)
  • Industrial Property Rights Holder: 林登志雄 (他2名1番目)
  • Filing Date: 2008-10-10
  • Overseas
• [Patent(Industrial Property Rights)] シトルリンとNO-(以下省略) (2008)
  • Inventor(s): 林登志雄, (他2名1番目)
  • Industrial Property Rights Holder: 林登志雄, (他2名1番目)
  • Filing Date: 2008-10-10
  • Overseas