Regulation of Adipokine Expression on Metabolic Syndrome

• Project/Area Number: 19591044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: MAEGAWA Hiroshi Shiga University of Medical Science, 医学部, 准教授 (00209363)
• Co-Investigator(Kenkyū-buntansha): 山本 寛 滋賀医科大学, 医学部, 助教 (00283557) ; 前田 士郎 理化学研究所, 遺伝子多型研究センター, チームリーダー (50314159)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Hiroshi 滋賀医科大学, 医学部, 准教授 (00283557) ; MAEDA Shiro 理化学研究所, 遺伝子多型研究センター, チームリーダー (50314159)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: メタボリックシンドローム / アディポサトカイン / 脂肪組織 / 肥満 / アディポネクチン / レプチン / 皮下脂肪組織 / 内臓脂肪組織 / TFAP2B / IL-6

Research Abstract

生検皮下脂肪組織および内臓脂肪組織を用いた検討により、アディポネクチン、レプチン、IL-6などのアディポサイトカイン発現量が、皮下脂肪組織および内臓脂肪組織において異なることが示唆され、さらに、2 型糖尿病とその遺伝子座が関連する転写因子TFAP2B の発現量が、脂肪組織におけるアディポサイトカイン発現を制御している可能性が示唆された。

Research Products

• [Journal Article] A. Transcription factor AP-2β : a positive regulator of MCP-1gene expression Endocrinology (2009)
  • Author(s): Kondo M, Maegawa H, Obata T, Ugi S, Ikeda K, Morino K, Nakai Y, Nishio Y, Maeda S, Kashiwagiu A
  • Journal Title: 150 Pages: 1654-61
  • Peer Reviewed
• [Journal Article] Postprandial hyperglycemia after gastrectomy and the prediabetic state : a comparison between distal and total gastrectomy (2008)
  • Author(s): Yamamoto H, Tsuchihashi H, Akabori H, Naitoh H, Maegawa, H, Tani T.
  • Journal Title: Surgery Today 38 Pages: 685-90
  • NAID: 10021940322
  • Peer Reviewed
• [Journal Article] Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study (2008)
  • Author(s): Sekikawa, A, Ueshima H, Sutton-Tyrrell K, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Ueno Y, Evans RW, Nakamura Y, Edmundowicz D, Kashiwagi A, Maegawa H, Kuller LH.
  • Journal Title: Metabolism 57 Pages: 177-182
  • Peer Reviewed
• [Journal Article] Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-binding Protein-1 Gene Expression (2007)
  • Author(s): Shi K, Ugi S , Shimizu S, Sekine O, Ikeda K,Egawa K, Yoshizaki T, Nagai Y, Nishio Y,Takada T, Torii R, Kimura H, Kashiwagi, A, Maegawa H
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 626-32
  • Peer Reviewed
• [Journal Article] Short-term low-dosage pioglitazone treatment improves vascular dysfunction in patients with type 2 diabetes Endocrine J. (2007)
  • Author(s): Maegawa H, Nishio Y, Nakao K, Ugi S, Maeda K, Uzu T, Kashiwagi A
  • Journal Title: 54 Pages: 613-618
  • Peer Reviewed
• [Journal Article] Less subclinical atherosclerosisin Japanese men in Japan than in white men in the United States in the post World-War-II birth cohort (2007)
  • Author(s): Sekikawa A, Ueshima H, Kadowaki T, El-Saedl A, Okamura T, Takamiya T,Kashiwagi A, Edmundowicz D, Murata K,Sutton-Tyrrell1 K, Maegawa H, Evans RW, Kita Y, Kuller LH and for the ERA JUMP Study Group
  • Journal Title: Am Jepidemiology 165 Pages: 617-24
  • Peer Reviewed
• [Journal Article] Increased expression of CCAAT/enhancer binding protein-beta and delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinemic rats (2007)
  • Author(s): Sato Y, Nishio Y, Sekine O, Kodama K, Nagai Y, Nakamura T, Maegawa H, Kashiwagi A
  • Journal Title: Diabetologia 50 Pages: 481-9
  • Peer Reviewed
• [Journal Article] Kashiwagi A RBMX is a novel heptic transcripitinal regulator of SREBP-1c gene to high-fructose diet (2007)
  • Author(s): Takemoto T, Nishio Y, Sekine O, Ikeuchi C,Nagai Y, Maeno Y, Maegawa H, Kimura H
  • Journal Title: FEBS letter 581 Pages: 218-22
  • Peer Reviewed
• [Journal Article] Increased expression of CCAAT/enhancer binding protein-beta and delta and monocyte chemoattractant protein-I genes in aortas from hyperinsulinemic rats (2007)
  • Author(s): Sato Y, et. al.
  • Journal Title: Diabetologia 50 Pages: 481-489
  • Peer Reviewed
• [Journal Article] Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-binding Protein-1 Gene Expression (2007)
  • Author(s): Shi K, et. al.
  • Journal Title: Biochem Biophys Res Commun 363 Pages: 626-632
  • Peer Reviewed
• [Journal Article] Soy Phosphatidyl-choline Inhibited TLR4-Mediated MCP-1 Expression in Vascular Cells Atherosclerosis
  • Author(s): Ishikado A, Nishio Y; Yamane K, Mukose; A, Morino K, Murakami Y, Sekine O, Makino T,Maegawa H, Kashiwagi A
  • Journal Title: (in press)
  • Peer Reviewed
• [Journal Article] Transcription factor AP-2β : a positive regulator of MCP-1 gene expression
  • Author(s): Kondo M, Maegawa H, et al
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Soy Phosphatidylcholine Inhibited TLR4-Mediated MCP-1 Expression in Vascular Cells
  • Author(s): Ishikada A, Maegawa H, et al.
  • Journal Title: Atherosclerosis (in press)
  • Peer Reviewed
• [Presentation] Safb1, an RBMX-Binding Protein, is a Newly Identified Activator in the Regulation of Hepatic SREBP-1c Gene Expression (2008)
  • Author(s): Omura Y, Nishio Y, Takemoto T, Ikeuchi C,Sekine O, Morino K, Maeno Y, Obata T, UgiS, Maegawa H, Kimura H, Kashiwagi A.
  • Organizer: The 68th annual meeting of American Diabetes Association
• [Presentation] Activation of TranscriptionFactor AP-2β Mediated by Protein Kinase Cμ Aggravates Expression of Inflammatory Adipokines in Differentiated Adipocyte (2008)
  • Author(s): Kondo M, Maegawa H, Morino K, Fuke T, Obata T, Ugi S, Nishio Y, Maeda S, Kashiwagi A
  • Organizer: The 68th annual meeting of American Diabetes Association
• [Presentation] Transcription Factor AP-2β Inhibits Glucose-Induced Insulin Secretion in Cultured Insulin-Secreting Cell Lines (2008)
  • Author(s): Tsukada S, Unoki H, Maegawa H,Kashiwagi A, Maeda S
  • Organizer: The 68th annual meeting of American Diabetes Association
• [Presentation] Transcription Factor AP-2[beta], A Novel Candidate Gene for Metabolic Syndrome,Accelerates MCP-1 Gene Expression in 3T3-L1 Adipocytes (2007)
  • Author(s): Maegawa H, Kondo M, Ikeda K, Fuke T, Nishio Y, Maeda S, Kashiwagi A
  • Organizer: 14th Japan - Korea Symposium on Diabetes Mellitus
• [Presentation] Transcription Factor AP-2[beta], A Novel Candidate Gene for Metabolic Syndrome, Accelerates MCP-1 Gene Expression in 3T3-L1 Adipocytes (2007)
  • Author(s): Kondo M, Maegawa H, Ikeda K, Fuke T,Nishio Y, Maeda S, Kashiwagi A
  • Organizer: The 67th annual meeting of American Diabetes Association
• [Presentation] Common Variants of the TCF7L2 are Associated with Susceptibility to Type 2 Diabetes, But Not with the Expression of TCF7L2 in the Adipose or Plasma GLP-1 Concentrations in a Japanese Population (2007)
  • Author(s): Hayashi T, Maegawa H, Babazono T,Yamamoyto H, Hirose H, Naito H, Tani T,Kawamori R, Kaku K, Kashiwagi A, Iwamoto Y, Maeda S
  • Organizer: The 67th annual meeting of American Diabetes Association
• [Presentation] Amelioration of Hepatic and Visceral Fat Deposition by Pioglitazone Treatment in Normoglycemic Patients with Metabolic Syndrome (2007)
  • Author(s): Tsuchiya M, Enomoto K, Kakaoka K, Iijima H, Nishio Y, Maegawa H, Kashiwagi A
  • Organizer: The 67th annual meeting of American Diabetes Association