| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Kir6.2, together with SUR1, forms an ATP-sensitive potassium (K_<ATP>) channel that plays a key role in insulin secretion from pancreatic ss-cells. In this study, we carried out functional analyses including electrophysiological analysis, and found significant differences in ATP-sensitivity, sulfonylurea-sensitivity, and membrane surface expression among the mutants. Furthermore, it is possible to evaluate the potential efficacy of these insulinotropic agents in patients with the mutation by using in vitro analyses.
|
