The inhibition of pancreatic b-cell deficiency and regenerationof β -cells by incretin signals
| Project/Area Number |
19591057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
MIYAMURA Nobuhiro Kumamoto University, 医学部・附属病院, 講師 (40274716)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Tatsuya 熊本大学, 医学部・附属病院, 医員 (70398204)
荒木 栄一 熊本大学, 大学院・医学薬学研究部, 教授 (10253733)
下田 誠也 熊本大学, 大学院・医学薬学研究部, 助教 (60398203)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKI Eiichi 熊本大学, 大学院・医学薬学研究部, 教授 (10253733)
SHIMODA Seiya 熊本大学, 大学院・医学薬学研究部, 助教 (60398203)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 糖尿病 / インクレチン / 膵β細胞 |
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| Research Abstract |
インクレチン投与により膵β細胞のアポトーシスが抑制され、小胞体ストレスマーカーとミトコンドリア由来活性酸素の抑制が認められた。またPDX-1陽性細胞を単離抽出し、網羅的遺伝子発現解析を行っており、新規膵β細胞分化因子の同定を目指す。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
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Journal Title
Biochem Biophys Res Commun 20 ; 379(4)
Pages: 806-11
Related Report
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[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
Author(s)
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun 376(2)
Pages: 434-8
Related Report
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[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
Author(s)
Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun 366(3)
Pages: 814-20
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[Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007
Author(s)
Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
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Journal Title
Biochem Biophys Res Commun 364(2)
Pages: 301-7
Related Report
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[Journal Article] Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake2007
Author(s)
Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T.
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Journal Title
Cell Metab 6(1)
Pages: 55-68
Related Report
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