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The molecular mechanisms of improvement of insulin resistance and reduction of visceral fat by combination of mild electrical current and thermo therapy

Research Project

Project/Area Number 19591058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionKumamoto University

Principal Investigator

KONDO Tatsuya  Kumamoto University, 医学部・附属病院, 医員 (70398204)

Co-Investigator(Kenkyū-buntansha) TSURUZOE Kaku  熊本大学, 医学部・附属病院, 助教 (50398202)
MOTOSHIMA Hiroyuki  熊本大学, 医学部・附属病院, 医員 (40398201)
MATSUMURA Takeshi  熊本大学, 医学部・附属病院, 医員 (20398192)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords温熱 / 微弱電流 / インスリン抵抗性 / 内臓脂肪 / 糖尿病 / 温熱電流同時印加療法 / Hsp72
Research Abstract

温熱と微弱電流の同時付与により、肝臓で増加6遺伝子・減少100遺伝子、皮下脂肪で増加100遺伝子・減少5遺伝子、筋肉で増加97遺伝子・減少53遺伝子、腸間膜脂肪で増加63遺伝子・減少43遺伝子を同定した。興味深い変動を示す遺伝子や機能的関連を示す遺伝子の発現レベルを定量的RT-PCRやWestern Blotで確認している。その結果で糖代謝関連候補遺伝子群を絞り、それらの発現制御による皮下脂肪・内臓脂肪量・耐糖能およびインスリン抵抗性の解析を目指す。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (29 results)

All 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (13 results) Book (3 results)

  • [Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009

    • Author(s)
      Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa. N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
    • Journal Title

      Biochem Biophys Res Commun 379(4)

      Pages: 806-11

    • Related Report
      2008 Final Research Report
  • [Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.2009

    • Author(s)
      Adachi H
    • Journal Title

      Biochem Biophys Res Commun. 379(4)

      Pages: 806-811

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling2008

    • Author(s)
      Morino S, Kondo T, Sasaki K, Adachi H, Suico MA, Sekimoto E, Matsuda T, Shuto T, Araki E, Kai H
    • Journal Title

      PLoS ONE 3(12)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation2008

    • Author(s)
      Morino S, Suico MA, Kondo T, Sekimoto E, Yano S, Matsuda T, Matsuno T, Shuto T, Araki E, Kai H.
    • Journal Title

      J Pharmacol Sci 108(2)

      Pages: 222-6

    • NAID

      10024385095

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008

    • Author(s)
      Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
    • Journal Title

      Biochem Biophys Res Commun 376(2)

      Pages: 434-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008

    • Author(s)
      Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
    • Journal Title

      Biochem Biophys Res Commun 366(3)

      Pages: 814-20

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.2008

    • Author(s)
      Morino S
    • Journal Title

      PLoS ONE. 3(12)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation.2008

    • Author(s)
      Morino S
    • Journal Title

      Journal of Pharmacological Science. 108(2)

      Pages: 222-226

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice.2008

    • Author(s)
      Goto H
    • Journal Title

      Biochem Biophys Res Commun. 366(3)

      Pages: 814-820

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007

    • Author(s)
      Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
    • Journal Title

      Biochem Biophys Res Commun 364(2)

      Pages: 301-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice2007

    • Author(s)
      Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR
    • Journal Title

      J Biol Chem 282(32)

      Pages: 23672-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake2007

    • Author(s)
      Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T
    • Journal Title

      Cell Metab 6(1)

      Pages: 55-68

    • Related Report
      2008 Final Research Report
  • [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.2007

    • Author(s)
      Murata Y
    • Journal Title

      Biochem Biophys Res Commun. 364(2)

      Pages: 301-307

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 一般演題「温熱・電流同時印加療法(MET)の健常人における安全性と慢性炎症マーカー低下効果」2008

    • Author(s)
      近藤龍也
    • Organizer
      第46回日本糖尿病学会九州地方会
    • Place of Presentation
      久留米市
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 温熱・電流同時印加療法(MET)の健常人における安全性と慢性炎症マーカー低下効果2008

    • Author(s)
      近藤龍也
    • Organizer
      第46回 日本糖尿病学会九州地方会
    • Place of Presentation
      久留米市
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム「分子シャペロンHsp72の物理的および薬理学的誘導による内臓脂肪減少・糖代謝改善効果」2008

    • Author(s)
      近藤龍也
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 一般演題「温熱・電流同時印加療法(MET)の健常人における安全性と慢性炎症マーカー低下効果」2008

    • Author(s)
      近藤龍也
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 分子シャペロンHsp72の物理的および薬理学的誘導による内臓脂肪減少・糖代謝改善効果2008

    • Author(s)
      近藤龍也
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポスター「健常人および動物を対象とした温熱電流同時印加療法による糖代謝改善効果の検討」2008

    • Author(s)
      近藤龍也
    • Organizer
      第105回日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 一般演題「温熱・電流同時印加療法(MET)によるdb/dbマウスのインスリン分泌改善効果」2007

    • Author(s)
      近藤龍也
    • Organizer
      第2回臨床応答ストレス学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 一般演題「温熱・電流同時印加療法(MET)によるdb/dbマウスのインスリン分泌改善効果」2007

    • Author(s)
      近藤龍也
    • Organizer
      第45回日本糖尿病学会九州地方会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] シンポジウム「2型糖尿病の成因と新しい治療法」2007

    • Author(s)
      近藤龍也
    • Organizer
      第45回日本糖尿病学会九州地方会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 局所ハイパーサーミアと微弱電流併用による2型糖尿病モデル(db/db)マウスのインスリン分泌改善効果2007

    • Author(s)
      近藤龍也
    • Organizer
      第24回日本ハイパーサーミア学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Mild Electrical Current and Hyperthermia Ameliorates Insulin Resistance and β-cell Function in Mice Models of Type 2 Diabetes2007

    • Author(s)
      近藤 龍也
    • Organizer
      67th American Diabetes Association Scientific Sessions
    • Place of Presentation
      米国、シカゴ
    • Year and Date
      2007-06-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] シンポジウム「膵β細胞機能障害における小胞体ストレスの関与と分子シャペロン誘導による膵β細胞保護」2007

    • Author(s)
      近藤龍也
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 一般演題「温熱・電流同時印加療法(MET)によるdb/dbマウスのインスリン分泌改善効果」2007

    • Author(s)
      近藤龍也
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Book] Diabetes Frontier第20巻6号、頁肥満治療の最前線9. 内臓脂肪に対する温熱微弱電流併用療法の効果2009

    • Author(s)
      近藤龍也、森野沙緒里、甲斐広文、荒木栄一
    • Publisher
      メディカルレビュー社
    • Related Report
      2008 Final Research Report
  • [Book] Diabetes Frontier 第20巻6号 「内臓脂肪に対する温熱微弱電流併用療法の効果」2009

    • Author(s)
      近藤龍也
    • Total Pages
      130
    • Publisher
      メディカルレビュー社
    • Related Report
      2008 Annual Research Report
  • [Book] Medical Science Digest(Vol.33(13))-小胞体ストレスと糖尿病-2007

    • Author(s)
      荒木 栄一
    • Publisher
      北隆館/ニューサイエンス社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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