The molecular mechanisms of improvement of insulin resistance and reduction of visceral fat by combination of mild electrical current and thermo therapy
| Project/Area Number |
19591058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
KONDO Tatsuya Kumamoto University, 医学部・附属病院, 医員 (70398204)
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| Co-Investigator(Kenkyū-buntansha) |
TSURUZOE Kaku 熊本大学, 医学部・附属病院, 助教 (50398202)
MOTOSHIMA Hiroyuki 熊本大学, 医学部・附属病院, 医員 (40398201)
MATSUMURA Takeshi 熊本大学, 医学部・附属病院, 医員 (20398192)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 温熱 / 微弱電流 / インスリン抵抗性 / 内臓脂肪 / 糖尿病 / 温熱電流同時印加療法 / Hsp72 |
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| Research Abstract |
温熱と微弱電流の同時付与により、肝臓で増加6遺伝子・減少100遺伝子、皮下脂肪で増加100遺伝子・減少5遺伝子、筋肉で増加97遺伝子・減少53遺伝子、腸間膜脂肪で増加63遺伝子・減少43遺伝子を同定した。興味深い変動を示す遺伝子や機能的関連を示す遺伝子の発現レベルを定量的RT-PCRやWestern Blotで確認している。その結果で糖代謝関連候補遺伝子群を絞り、それらの発現制御による皮下脂肪・内臓脂肪量・耐糖能およびインスリン抵抗性の解析を目指す。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa. N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
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Journal Title
Biochem Biophys Res Commun 379(4)
Pages: 806-11
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[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
Author(s)
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
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Journal Title
Biochem Biophys Res Commun 376(2)
Pages: 434-8
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[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
Author(s)
Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun 366(3)
Pages: 814-20
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[Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007
Author(s)
Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
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Journal Title
Biochem Biophys Res Commun 364(2)
Pages: 301-7
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[Journal Article] Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake2007
Author(s)
Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T
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Journal Title
Cell Metab 6(1)
Pages: 55-68
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