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Role of reactive oxygen species in white and brown adipose tissuesin pathogenesis of insulin resistance

Research Project

Project/Area Number 19591059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionKumamoto University

Principal Investigator

TSURUZOE Kaku  Kumamoto University, 医学部・附属病院, 助教 (50398202)

Co-Investigator(Kenkyū-buntansha) 荒木 栄一  熊本大学, 大学院・医学薬学研究部, 教授 (10253733)
西川 武志  熊本大学, 大学院・医学薬学研究部, 助教 (70336212)
Co-Investigator(Renkei-kenkyūsha) ARAKI Eiichi  熊本大学, 大学院・医学薬学研究部, 教授 (10253733)
NISHIKAWA Takeshi  熊本大学, 大学院・医学薬学研究部, 助教 (70336212)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖尿病学 / 糖尿病 / 脂肪 / 酸化ストレス / MnSOD / インスリン抵抗性 / 糖尿病合併症 / 脂肪組織
Research Abstract

脂肪組織におけるミトコンドリア由来酸化ストレスmtROSがインスリン抵抗性に及ぼす影響について、mtROS特異的除去酵素であるManganese SOD(MnSOD)を中心としたin vivo解析、in vitro解析を行った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results)

  • [Journal Article] Angptl 4 deficiencyimproves lipid metabolism, suppresses foamcell formation and protects against atherosclerosis2009

    • Author(s)
      Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E.
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 806-811

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.2009

    • Author(s)
      Adachi H
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 806-811

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidized low density lipoprotein activatesperoxisome proliferator-activatedreceptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages2008

    • Author(s)
      Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
    • Journal Title

      J Biol Chem 283

      Pages: 9852-98621

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008

    • Author(s)
      Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
    • Journal Title

      Biochem Biophys Res Commun 376

      Pages: 434-438

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice2008

    • Author(s)
      Goto H, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E.
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 814-820

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rottlerin activates AMPK possibly through LKBl in vascular cells and tissues.2008

    • Author(s)
      Kojima K
    • Journal Title

      Biochem Biophys Res Commun 376

      Pages: 434-438

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha)and PPARgamma through MAPK-dependent COX-2 expression in macrophages.2008

    • Author(s)
      Taketa K
    • Journal Title

      J Biol Chem 283

      Pages: 9852-9862

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice.2008

    • Author(s)
      Goto H.
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 814-820

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007

    • Author(s)
      Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, IgataM, Taketa K, Sasaki K, Kishikawa H, KahnCR, Toyonaga T, Araki E.
    • Journal Title

      Biochem Biophys Res Commun 364

      Pages: 301-307

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.2007

    • Author(s)
      Murata Y.
    • Journal Title

      Biochem Biophys Res Commun 364

      Pages: 301-307

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病と心疾患2008

    • Author(s)
      水流添覚
    • Organizer
      第5回九州心臓核医学研究会シンポジウム
    • Place of Presentation
      福岡市
    • Year and Date
      2008-08-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖尿病と心疾患2008

    • Author(s)
      水流添 覚
    • Organizer
      第5回九州心臓核医学研究会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-08-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] IRS-1過剰発現マウスにおける脂肪蓄積と糖代謝についての解析2007

    • Author(s)
      水流添 覚(代表者)
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] IRS-1遺伝子導入による脂肪量増加と耐糖能障害2007

    • Author(s)
      水流添覚, 村田雄介, 竹田佳代, 近藤龍也, 本島寛之, 荒木栄一
    • Organizer
      第45回日本糖尿病学会九州地方会
    • Place of Presentation
      宮崎市
    • Related Report
      2008 Final Research Report
  • [Presentation] IRS-1過剰発現における脂肪蓄積と糖代謝についての解析2007

    • Author(s)
      水流添覚, 村田雄介, 豊永哲至, 古川昇, 近藤龍也, 本島寛之, 井形元維, 竹田佳代, 佐々木一成, 荒木栄一
    • Organizer
      第50回日本糖尿病学会総会
    • Place of Presentation
      仙台市
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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