Role of reactive oxygen species in white and brown adipose tissuesin pathogenesis of insulin resistance

• Project/Area Number: 19591059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: TSURUZOE Kaku Kumamoto University, 医学部・附属病院, 助教 (50398202)
• Co-Investigator(Kenkyū-buntansha): 荒木 栄一 熊本大学, 大学院・医学薬学研究部, 教授 (10253733) ; 西川 武志 熊本大学, 大学院・医学薬学研究部, 助教 (70336212)
• Co-Investigator(Renkei-kenkyūsha): ARAKI Eiichi 熊本大学, 大学院・医学薬学研究部, 教授 (10253733) ; NISHIKAWA Takeshi 熊本大学, 大学院・医学薬学研究部, 助教 (70336212)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 糖尿病学 / 糖尿病 / 脂肪 / 酸化ストレス / MnSOD / インスリン抵抗性 / 糖尿病合併症 / 脂肪組織

Research Abstract

脂肪組織におけるミトコンドリア由来酸化ストレスmtROSがインスリン抵抗性に及ぼす影響について、mtROS特異的除去酵素であるManganese SOD(MnSOD)を中心としたin vivo解析、in vitro解析を行った。

Research Products

• [Journal Article] Angptl 4 deficiencyimproves lipid metabolism, suppresses foamcell formation and protects against atherosclerosis (2009)
  • Author(s): Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E.
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 806-811
  • Peer Reviewed
• [Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. (2009)
  • Author(s): Adachi H
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 806-811
  • Peer Reviewed
• [Journal Article] Oxidized low density lipoprotein activatesperoxisome proliferator-activatedreceptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages (2008)
  • Author(s): Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
  • Journal Title: J Biol Chem 283 Pages: 9852-98621
  • Peer Reviewed
• [Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues (2008)
  • Author(s): Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
  • Journal Title: Biochem Biophys Res Commun 376 Pages: 434-438
  • Peer Reviewed
• [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice (2008)
  • Author(s): Goto H, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 814-820
  • Peer Reviewed
• [Journal Article] Rottlerin activates AMPK possibly through LKBl in vascular cells and tissues. (2008)
  • Author(s): Kojima K
  • Journal Title: Biochem Biophys Res Commun 376 Pages: 434-438
  • Peer Reviewed
• [Journal Article] Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha)and PPARgamma through MAPK-dependent COX-2 expression in macrophages. (2008)
  • Author(s): Taketa K
  • Journal Title: J Biol Chem 283 Pages: 9852-9862
  • Peer Reviewed
• [Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice. (2008)
  • Author(s): Goto H.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 814-820
  • Peer Reviewed
• [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance (2007)
  • Author(s): Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, IgataM, Taketa K, Sasaki K, Kishikawa H, KahnCR, Toyonaga T, Araki E.
  • Journal Title: Biochem Biophys Res Commun 364 Pages: 301-307
  • Peer Reviewed
• [Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance. (2007)
  • Author(s): Murata Y.
  • Journal Title: Biochem Biophys Res Commun 364 Pages: 301-307
  • Peer Reviewed
• [Presentation] 糖尿病と心疾患 (2008)
  • Author(s): 水流添覚
  • Organizer: 第5回九州心臓核医学研究会シンポジウム
  • Place of Presentation: 福岡市
  • Year and Date: 2008-08-02
• [Presentation] 糖尿病と心疾患 (2008)
  • Author(s): 水流添 覚
  • Organizer: 第5回九州心臓核医学研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-08-02
• [Presentation] IRS-1過剰発現マウスにおける脂肪蓄積と糖代謝についての解析 (2007)
  • Author(s): 水流添 覚(代表者)
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台市
  • Year and Date: 2007-05-25
• [Presentation] IRS-1遺伝子導入による脂肪量増加と耐糖能障害 (2007)
  • Author(s): 水流添覚, 村田雄介, 竹田佳代, 近藤龍也, 本島寛之, 荒木栄一
  • Organizer: 第45回日本糖尿病学会九州地方会
  • Place of Presentation: 宮崎市
• [Presentation] IRS-1過剰発現における脂肪蓄積と糖代謝についての解析 (2007)
  • Author(s): 水流添覚, 村田雄介, 豊永哲至, 古川昇, 近藤龍也, 本島寛之, 井形元維, 竹田佳代, 佐々木一成, 荒木栄一
  • Organizer: 第50回日本糖尿病学会総会
  • Place of Presentation: 仙台市