Etiology of fulminant type 1 diabetes -analysis of the pancreas tissues
| Project/Area Number |
19591069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
HANAFUSA Toshiaki Osaka Medical College, 医学部, 教授 (60164886)
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| Co-Investigator(Kenkyū-buntansha) |
IMAGAWA Akihisa 大阪医科大学, 医学部, 非常勤講師 (80373108)
飯野 守男 京都大学, 医学系研究科, 助教 (80362466)
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| Co-Investigator(Renkei-kenkyūsha) |
IINO Morio 京都大学, 医学系研究科, 助教 (80362466)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 1型糖尿病 / 劇症 / 膵 / ウィルス / マクロファージ / T細胞 / ウイルス / toll-like receptor / 免疫組織化学 / in situ hybridization / in situ hvbridization |
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| Research Abstract |
私どもが発見・確立した劇症1型糖尿病患者の剖検膵組織(合計3症例)を分析し、RNAレベルでエンテロウイルスの発現を認めた症例が存在すること、膵島浸潤細胞の主体がCD68陽性マクロファージであり、3症例すべてにおいて90%以上の膵島に浸潤していること、膵島に浸潤しているマクロファージにtoll-like receptor(TLR)-3, 7, 8, 9が発現していることを明らかにした。
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes2008
Author(s)
Imagawa A, Hanafusa T, Iwahashi H, Uchigata Y, Kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I, Maruyama T, Makino H.
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Journal Title
Diabetes Res Clin Pract 82(2)
Pages: 233-7
Related Report
Peer Reviewed
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[Journal Article] Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitus2008
Author(s)
Takaike H, Uchigata Y, Iwamoto Y, Imagawa A, Iwahashi H, Kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I, Hanafusa T, Maruyama T, Makino H
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Journal Title
Ann Med 40(5)
Pages: 395-400
Related Report
Peer Reviewed
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[Journal Article] Insulin administration may trigger pancreatic b cell destruction in patients with type 2 diabetes2008
Author(s)
Nakamura M, Nishida W, Yamada Y, Chujo D, Watanabe Y, Imagawa A, Hanafusa T, Kawasaki E, Onuma H, Osawa H, Makino H.
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Journal Title
Diabetes Res Clin Pract 79(2)
Pages: 220-9
Related Report
Peer Reviewed
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