Molecular mechanism for the contribution of TFAP2B and KLF7 to the onset of type 2 diabetes
| Project/Area Number |
19591070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAEDA Shiro The Institute of Physical and Chemical Research, 内分泌・代謝疾患研究チーム, チームリーダー (50314159)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 2型糖尿病 / 膵β細胞 / インスリン分泌 / 遺伝子 |
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| Research Abstract |
本研究は当研究チームで発見した新規2型糖尿病疾患感受性遺伝子TFAP2B、KLF7の2型糖尿病発症に関わる分子機構の解明を目的とした。ハムスター由来のインスリン分泌細胞(HIT-T15)を用いてインスリン分泌を検討したところ、TFAP2B,KLF7ともグルコースによるインスリン分泌を著明に抑制した。このTFAP2Bのインスリン分泌抑制効果は一部GLUT2, Kir6.2, HNF4A発現減少を介している事も明らかとなった。さらにTFAP2Bの膵β細胞特異的トランスジェニックマウスを作成し解析を開始しているが現時点では耐糖能異常等の表現形は認められていない。
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Variation in the gene encoding Kruppel-like factor 7 influence body fat:studies of 14,818 Danes2009
Author(s)
Zobel D, Andreasen C, Burgdorf K, Andersson E, Sandbak A, Lauritzen T, Borch-Johnsen K, Jorgensen T, Maeda S, Nakamura Y, Eiberg H, Pedersen O, Hansen T
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Journal Title
Eur J Endocrinol. 160
Pages: 603-609
Related Report
Peer Reviewed
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[Journal Article] Replication study for the association of new meta-analysis derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals2009
Author(s)
Omori S, Tanaka Y, Horikoshi M, Takahashi A, Hara K, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Kadowaki T, Nakamura Y, Maeda S
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Journal Title
Diabetologia (in press)
Pages: 0-0
Related Report
Peer Reviewed
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[Journal Article] Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8 and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population2008
Author(s)
Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S
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Journal Title
Diabetes 57
Pages: 791-795
Related Report
Peer Reviewed
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[Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in a East Asian and European populations2008
Author(s)
Unoki1 H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DPK, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbak A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose1 H, Hayashi1 M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S
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Journal Title
Nat Genet 40
Pages: 1097-1102
Related Report
Peer Reviewed
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[Presentation] Polymorphisms within CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8 and KCNJ11 Are Associated With Susceptibility to Type 2 Diabetes in a Japanese Population2008
Author(s)
Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S
Organizer
American Diabetes Association 68th Scientific Sessions
Related Report
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