Molecular mechanism of difference of estrogen sensitivity and response to endocrine therapy in breast and endometrial cancers
Project/Area Number |
19591071
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Tohoku University |
Principal Investigator |
HAYASHI Shin-ichi Tohoku University, 大学院・医学系研究科, 教授 (60144862)
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Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Yuri 埼玉県立がんセンター, 臨床腫瘍研究所, 主任研究員 (80166628)
八重樫 伸生 東北大学, 医学系研究科, 教授 (00241597)
鈴木 貴 東北大学, 医学部, 教授 (10261629)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 子宮内膜癌 / 乳癌 / エストロゲン / マイクロアレイ / ホルモン療法 / 核内受容体 |
Research Abstract |
Microarray analysis of the breast and endometrial cancer revealed that the expression profile of their ER-response genes was significantly different from each others. The cancer microenvironment of the endometrial cancer showed ER activating ability as similar to that in breast cancer. Furthermore, endometrial cancer cells obtained from surgical specimens showed substantial ER activity by ERE-GFP adenovirus assay. These results suggest that aromatase inhibitor may have some therapeutic value in some endometrial cancers.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article]2009
Author(s)
林慎一
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Journal Title
「みんなに役立つ乳癌の基礎と臨床」(戸井雅和編)(医薬ジャーナル 株式会社)
Pages: 53-63
Related Report
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[Journal Article] Loss of estrogen receptor b isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epitherial ovarian carcinoma2008
Author(s)
Suzuki, F., Akahira, J., Miura, I., Suzuki, T., Ito, K., Hayashi, S., Sasano, H., Yaegashi, N.
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Journal Title
Cancer Sci. 99
Pages: 2365-2372
Related Report
Peer Reviewed
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[Journal Article] Intratumoral Estrogens and Estrogen Receptors in Human Non-Small Cell Lung Carcinoma2008
Author(s)
Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J, Honma S, Evans DB, Hayashi S, Kondo T, Sasano H.
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Journal Title
Clin Cancer Res. 14
Pages: 4417-4426
Related Report
Peer Reviewed
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[Journal Article] Midkine and its clinical significance in endometrial cancer2008
Author(s)
Tanabe, K., Matsumoto, M., Ikematsu, S., Nagase, S., Hatakeyama, A., Takano, T., Niikura, H., Ito, K., Kadomatsu, K., Hayashi, S., Yaegashi, N.
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Journal Title
Cancer Sci. 99
Pages: 267-271
Related Report
Peer Reviewed
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[Journal Article] Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction2008
Author(s)
Matsumoto, M., Yamaguchi, Y., Seino, Y., Hatakeyama, A., Takei, H., Niikura, H., Ito, K., Suzuki, T., Sasano, H., Yaegashi, N. Hayashi, S.
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Journal Title
Endocrine-Related Cancer 15
Pages: 451-463
Related Report
Peer Reviewed
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[Journal Article] The expression of retinoic acid receptors in human endometrial carcinoma2008
Author(s)
Tanabe, K., Utsunomiya, H., Tamura, M., Niikura, H., Takano, T., Yoshinaga, K., Nagase, S., Suzuki, T., Ito, K., Matsumoto, M., Hayashi, S. Yaegashi, N.
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Journal Title
Cancer Sci. 99
Pages: 1125-1130
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 expression in breast cancer2007
Author(s)
Mita, K., Zhang, Z., Ando, Y., Toyama, T., Hamaguchi, M., Kobayashi, S., Hayashi, S., Fujii, Y., Iwase, H. Yamashita, H.
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Journal Title
Jpn.J.Clin.Oncol. 37(8)
Pages: 575-582
Related Report
Peer Reviewed
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[Journal Article] Early growth responsive gene 3 (EGR3) in human breast carcinoma : a regulator of estrogen-mediated invasion and a potent prognostic factor2007
Author(s)
Suzuki, T., Inoue, A., Miki, Y., Moriya T., Ishida, T., Hirakawa, H., Yamaguchi, Y., Hayashi, S. Sasano, H.
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Journal Title
Endocrine-Related Cancer 14
Pages: 279-292
Related Report
Peer Reviewed
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[Journal Article] Aromatase localization in human breast cancer tissues-possible interaction between intratumoral stromal and parenchymal cells2007
Author(s)
Miki, Y., Suzuki, T., Tazawa C., Yamaguchi, Y., Kitada, K., Honma, S., Moriya, T., Hirakawa, H., Evans, D.B., Hayashi, S., Ohuchi, N. Sasano, H.
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Journal Title
Cancer Res. 67(8)
Pages: 3945-3954
Related Report
Peer Reviewed
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[Journal Article] Demethylation of promoter C region of estrogen receptor α gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells2007
Author(s)
Sogon, T., Masamura, S., Hayashi, S., Santene, R.J., Nakachi, K., Eguchi, H.
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Journal Title
J.Steroid Biochem.Mol.Biol. 105
Pages: 106-114
Related Report
Peer Reviewed
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[Journal Article] Comparative profilimg of the gene expression for estrogen responsiveness in cultured human cell lines2007
Author(s)
Inoue, A., Seino, Y., Terasaka, S., Hayashi, S., Yamori, T., Tanji, M. Kiyama, R.
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Journal Title
Toxicology In Vitro 21
Pages: 741-752
Related Report
Peer Reviewed
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[Journal Article] 5・-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production2007
Author(s)
Suzuki, T., Miki, Y., Moriya, T., Akahira, J., Ishida, T., Hirakawa, H., Yamaguchi, Y., Hayashi, S. Sasano, H.
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Journal Title
Int.J.Cancer 120
Pages: 285-291
Related Report
Peer Reviewed
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[Presentation] ユビキチンリガーゼCHIPは癌の浸潤性を抑制する2008
Author(s)
神代理史, 相馬佳絵, 村山明子, 仲島由佳, 藤村亜紀子, 大家祥平, 山口ゆり, 川野輪香織, 木村圭志, 黒住昌史, 林慎一, 柳澤純
Organizer
第31回日本分子生物学会年会、第81回日本生化学会合同大会
Place of Presentation
神戸
Year and Date
2008-12-09
Related Report
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[Presentation] In vivo assessment of estrogen signal-related function of carcinoma-associated fibroblast (CAF) in human breast cancer2008
Author(s)
Yamaguchi, Y., Seino, Y., Oba, H., Takei, H., Kurosumi, M., Hayashi, S.
Organizer
13th International Congress on Hormonal Steroids and Hormones & Cancer
Place of Presentation
ケベック
Year and Date
2008-09-27
Related Report
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[Presentation] Expression of estrogen receptor(ER) beta isoforms and its correlation with DNA methylation in human epithelial ovarian cancer2008
Author(s)
F Suzuki, J Akahira, I Miura, S Nagase, T Takano, H Niikura, T Suzuki, K Ito, S Hayashi, H Sasano, N Yaegashi
Organizer
AMERICAN SOCIETY OF CLINICAL ONCOLOGY
Place of Presentation
Chicago
Year and Date
2008-05-30
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