Investigation of membrane receptor Ryk on bone metabolism and the therapeutic application to osteoporosis
| Project/Area Number |
19591081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyushu University |
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Principal Investigator |
OHNAKA Keizo Kyushu University, 大学院・医学研究院, 講師 (30325518)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYANAGI Ryoichi 九州大学, 大学院・医学研究院, 教授 (30154917)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨芽細胞 / Wntシグナル / Ryk |
|---|
| Research Abstract |
The Wnt/LRP5 signal plays important roles in promoting bone formation in rodents and human. This study investigated the involvement of Wnt co-receptor Ryk (receptor-related tyrosine kinase) in Wnt-induced bone formation signaling in cultured osteoblastic cells. Association study between the SNPs in Wnt signal-related genes and bone mineral density (BMD) was performed in postmenopausal Japanese women.
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Report
(4 results)
Research Products
(18 results)
